{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:56:58Z","timestamp":1793818618369,"version":"4.6.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Xinjiang Autonomous Region graduate innovation project","award":["XJ2023G201"],"award-info":[{"award-number":["XJ2023G201"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060166"],"award-info":[{"award-number":["82060166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Laparoscopic sleeve gastrectomy combined with fundoplication (LSGFD) can significantly control body weight and achieve effective anti-reflux effects. The aim of this study is to investigate the correlation between the alteration in Ghrelin levels and weight loss following SGFD, and to compare Ghrelin levels, weight loss and metabolic improvements between SG and SGFD, with the objective of contributing to the existing body of knowledge on SGFD technique in the management of patients with obesity and gastroesophageal reflux disease (GERD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective analysis was conducted on the clinical data of 115 obese patients who underwent bariatric surgery between March 2023 and June 2023 at the Department of Minimally Invasivew Surgery, Hernia and Abdominal Wall Surgery, People\u2019s Hospital of Xinjiang Uygur Autonomous Region. The subjects were divided into two groups based on surgical methods: sleeve gastrectomy group (SG group, 93 cases) and sleeve gastrectomy combined with fundoplication group (SGFD group, 22 cases). Clinical data, such as ghrelin levels before and after the operation, were compared between the two groups, and the correlation between changes in ghrelin levels and weight loss effectiveness after the operation was analyzed. Results: Three months after the operation, there was no significant difference in body mass, BMI, EWL%, fasting blood glucose, triglyceride, cholesterol, and uric acid levels between the SG and SGFD groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). However, the SGFD group exhibited a significant decrease in body weight, BMI, and uric acid levels compared to preoperative levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while the decrease in ghrelin levels was not statistically significant (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Logistic regression analysis indicated that ghrelin levels three months after the operation were influential in postoperative weight loss.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The reduction of plasma Ghrelin level in patients after SGFD is not as obvious as that in patients after SG, but it can make obese patients get the same good weight loss and metabolic improvement as patients after SG. Ghrelin level at the third month after operation is the influencing factor of postoperative weight loss.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-024-02468-2","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:02:21Z","timestamp":1717574541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Correlation analysis between the changes in plasma ghrelin level and weight loss after sleeve gastrectomy combined with fundoplication"],"prefix":"10.1186","volume":"24","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikebaier","family":"Aili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyeguli","family":"Aipire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierdiwasi","family":"Maimaitiyusupu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maimaitiaili","family":"Maimaitiming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelimu","family":"Abudureyimu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"issue":"10026","key":"2468_CR1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(16)30054-X","volume":"387","author":"S McLachlan","year":"2016","unstructured":"McLachlan S, Collaboration NRF, et al. Trends in adult body mass index in 200 countries since 1975: pooled analysis of 1,698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387(10026):1377\u201396.","journal-title":"Lancet."},{"issue":"5","key":"2468_CR2","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","volume":"15","author":"M Bl\u00fcher","year":"2019","unstructured":"Bl\u00fcher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288\u201398.","journal-title":"Nat Rev Endocrinol"},{"key":"2468_CR3","doi-asserted-by":"publisher","first-page":"4754","DOI":"10.1007\/s11695-021-05628-y","volume":"31","author":"MS Altieri","year":"2021","unstructured":"Altieri MS, Irish W, Pories WJ, Shah A, DeMaria EJ. Examining the rates of obesity and bariatric surgery in the United States. Obes Surg. 2021;31:4754\u201360.","journal-title":"Obes Surg"},{"issue":"6","key":"2468_CR4","doi-asserted-by":"publisher","first-page":"861","DOI":"10.2337\/dc16-0236","volume":"39","author":"F Rubino","year":"2016","unstructured":"Rubino F, Nathan DM, Eckel RH, Schauer PR, Alberti KGM, Zimmet PZ, et al. Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations. Diabetes Care. 2016;39(6):861\u201377.","journal-title":"Diabetes Care"},{"issue":"3","key":"2468_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.soard.2019.11.018","volume":"16","author":"H Nasser","year":"2020","unstructured":"Nasser H, Munie S, Kindel TL, Gould JC, Higgins RM. Comparative analysis of robotic versus laparoscopic revisional bariatric surgery: perioperative outcomes from the MBSAQIP database. Surg Obes Relat Dis. 2020;16(3):397\u2013405.","journal-title":"Surg Obes Relat Dis"},{"key":"2468_CR6","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1007\/s11695-017-2748-9","volume":"27","author":"DM Felsenreich","year":"2017","unstructured":"Felsenreich DM, Kefurt R, Schermann M, Beckerhinn P, Kristo I, Krebs M, et al. Reflux, sleeve dilation, and Barrett\u2019s esophagus after laparoscopic sleeve gastrectomy: long-term follow-up. Obes Surg. 2017;27:3092\u2013101.","journal-title":"Obes Surg"},{"key":"2468_CR7","doi-asserted-by":"publisher","first-page":"1041889","DOI":"10.3389\/fendo.2022.1041889","volume":"13","author":"A Aili","year":"2022","unstructured":"Aili A, Maimaitiming M, Maimaitiyusufu P, Tusuntuoheti Y, Li X, Cui J, et al. Gastroesophageal reflux related changes after sleeve gastrectomy and sleeve gastrectomy with fundoplication: a retrospective single center study. Front Endocrinol. 2022;13:1041889.","journal-title":"Front Endocrinol"},{"issue":"6762","key":"2468_CR8","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/45230","volume":"402","author":"M Kojima","year":"1999","unstructured":"Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656\u201360.","journal-title":"Nature"},{"key":"2468_CR9","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1007\/s11695-016-2505-5","volume":"27","author":"N Alamuddin","year":"2017","unstructured":"Alamuddin N, Vetter ML, Ahima RS, Hesson L, Ritter S, Minnick A, et al. Changes in fasting and prandial gut and adiposity hormones following vertical sleeve gastrectomy or Roux-en-Y-gastric bypass: an 18-month prospective study. Obes Surg. 2017;27:1563\u201372.","journal-title":"Obes Surg"},{"key":"2468_CR10","doi-asserted-by":"publisher","unstructured":"Eisenberg D, Shikora SA, Aarts E, et al. 2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Indications for metabolic and bariatric surgery. Obes Surg. 2023;33(1):3\u201314. https:\/\/doi.org\/10.1007\/s11695-022-06332-1.","DOI":"10.1007\/s11695-022-06332-1"},{"issue":"1","key":"2468_CR11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41366-020-00711-3","volume":"45","author":"S Castorina","year":"2021","unstructured":"Castorina S, Barresi V, Luca T, Privitera G, De Geronimo V, Lezoche G, et al. Gastric ghrelin cells in obese patients are hyperactive. Int J Obes. 2021;45(1):184\u201394.","journal-title":"Int J Obes"},{"key":"2468_CR12","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ghir.2019.08.004","volume":"48","author":"F Faim","year":"2019","unstructured":"Faim F, Passaglia P, Batalhao M, Lacchini R, Stabile AM, Carnio EC. Role of ghrelin on growth hormone\/insulin-like growth factor-1 axis during endotoxemia. Growth Hormon IGF Res. 2019;48:36\u201344.","journal-title":"Growth Hormon IGF Res"},{"issue":"8","key":"2468_CR13","first-page":"MC13","volume":"8","author":"N Khatib","year":"2014","unstructured":"Khatib N, Gaidhane S, Gaidhane AM, Khatib M, Simkhada P, Gode D, et al. Ghrelin: ghrelin as a regulatory Peptide in growth hormone secretion. J Clin Diag Res. 2014;8(8):MC13.","journal-title":"J Clin Diag Res."},{"issue":"7","key":"2468_CR14","doi-asserted-by":"publisher","first-page":"e12705","DOI":"10.1111\/jne.12705","volume":"31","author":"SM Gray","year":"2019","unstructured":"Gray SM, Page LC, Tong J. Ghrelin regulation of glucose metabolism. J Neuroendocrinol. 2019;31(7):e12705.","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"2468_CR15","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0896-6273(03)00063-1","volume":"37","author":"MA Cowley","year":"2003","unstructured":"Cowley MA, Smith RG, Diano S, Tsch\u00f6p M, Pronchuk N, Grove KL, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 2003;37(4):649\u201361.","journal-title":"Neuron."},{"key":"2468_CR16","doi-asserted-by":"publisher","first-page":"137972","DOI":"10.3389\/fendo.2015.00044","volume":"6","author":"A Cabral","year":"2015","unstructured":"Cabral A, De Francesco PN, Perello M. Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom. Front Endocrinol. 2015;6:137972.","journal-title":"Front Endocrinol"},{"key":"2468_CR17","doi-asserted-by":"publisher","first-page":"153960","DOI":"10.1016\/j.metabol.2019.153960","volume":"100","author":"A Kokkinos","year":"2019","unstructured":"Kokkinos A, Tsilingiris D, le Roux CW, Rubino F, Mantzoros CS. Will medications that mimic gut hormones or target their receptors eventually replace bariatric surgery? Metabolism. 2019;100:153960.","journal-title":"Metabolism"},{"issue":"1","key":"2468_CR18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tem.2015.09.010","volume":"27","author":"JM Zigman","year":"2016","unstructured":"Zigman JM, Bouret SG, Andrews ZB. Obesity impairs the action of the neuroendocrine ghrelin system. Trends Endocrinol Metab. 2016;27(1):54\u201363.","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"2468_CR19","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.nut.2015.12.034","volume":"32","author":"M Fran\u00e7ois","year":"2016","unstructured":"Fran\u00e7ois M, Barde S, Legrand R, Lucas N, Azhar S, El Dhaybi M, et al. Highfat diet increases ghrelin-expressing cells in stomach, contributing to obesity. Nutrition. 2016;32(6):709\u201315.","journal-title":"Nutrition"},{"issue":"1","key":"2468_CR20","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1530\/JOE-15-0139","volume":"226","author":"F Naznin","year":"2015","unstructured":"Naznin F, Toshinai K, Waise TZ, NamKoong C, Moin ASM, Sakoda H, et al. Dietinduced obesity causes peripheral and central ghrelin resistance by promoting inflammation. J Endocrinol. 2015;226(1):81.","journal-title":"J Endocrinol"},{"issue":"6","key":"2468_CR21","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1210\/jc.2003-031964","volume":"89","author":"F Broglio","year":"2004","unstructured":"Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, et al. Nonacylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab. 2004;89(6):3062\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"2468_CR22","doi-asserted-by":"publisher","first-page":"101972","DOI":"10.1016\/j.npep.2019.101972","volume":"78","author":"M Su","year":"2019","unstructured":"Su M, Yan M, Gong Y. Ghrelin fiber projections from the hypothalamic arcuate nucleus into the dorsal vagal complex and the regulation of glycolipid metabolism. Neuropeptides. 2019;78:101972.","journal-title":"Neuropeptides"},{"issue":"3","key":"2468_CR23","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1152\/physrev.00021.2017","volume":"98","author":"W Al-Najim","year":"2018","unstructured":"Al-Najim W, Docherty NG, le Roux CW. Food intake and eating behavior after bariatric surgery. Physiol Rev. 2018;98(3):1113\u201341.","journal-title":"Physiol Rev"},{"issue":"5","key":"2468_CR24","doi-asserted-by":"publisher","first-page":"574","DOI":"10.5603\/EP.2018.0059","volume":"69","author":"M Dyaczy\u0144ski","year":"2018","unstructured":"Dyaczy\u0144ski M, Scanes CG, Koziec H, Pierzcha-la-Koziec K. Endocrine implications of obesity and bariatric surgery. Endokrynol Pol. 2018;69(5):574\u201397.","journal-title":"Endokrynol Pol"},{"issue":"4","key":"2468_CR25","doi-asserted-by":"publisher","first-page":"554","DOI":"10.5114\/wiitm.2014.45437","volume":"9","author":"M Bu\u017ega","year":"2014","unstructured":"Bu\u017ega M, Zavadilov\u00e1 V, Hol\u00e9czy P, \u0160vagera Z, \u0160vorc P, Foltys A, et al. Dietary intake and ghrelin and leptin changes after sleeve gastrectomy. Videosurgery Miniinv. 2014;9(4):554\u201361.","journal-title":"Videosurgery Miniinv"},{"issue":"3","key":"2468_CR26","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1172\/JCI76305","volume":"125","author":"S Manning","year":"2015","unstructured":"Manning S, Pucci A, Batterham RL, et al. Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms. J Clin Investig. 2015;125(3):939\u201348.","journal-title":"J Clin Investig"},{"key":"2468_CR27","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1007\/s11695-020-04601-5","volume":"30","author":"C Tuero","year":"2020","unstructured":"Tuero C, Valenti V, Rotellar F, Landecho MF, Cienfuegos JA, Fr\u00fchbeck G. Revisiting the ghrelin changes following bariatric and metabolic surgery. Obes Surg. 2020;30:2763\u201380.","journal-title":"Obes Surg."},{"issue":"2","key":"2468_CR28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.soard.2016.08.025","volume":"13","author":"P Kalinowski","year":"2017","unstructured":"Kalinowski P, Paluszkiewicz R, Wr\u00f3blewski T, Remiszewski P, Grodzicki M, Bartoszewicz Z, et al. Ghrelin, leptin, and glycemic control after sleeve gastrectomy versus Roux-en-\u03b3 gastric bypass-results of a randomized clinical trial. Surg Obes Relat Dis. 2017;13(2):181\u20138.","journal-title":"Surg Obes Relat Dis"},{"issue":"2","key":"2468_CR29","first-page":"89","volume":"67","author":"MIN Garc\u00eda","year":"2020","unstructured":"Garc\u00eda MIN, Mart\u00ednez RGC, P\u00e9rez NT, Barba ER, Periago MJ, Rojas JLV. Fasting ghrelin levels after gastric bypass and vertical sleeve gastrectomy: an analytical cohort study. Endocrinol Diabetes Nutr (Engl Ed). 2020;67(2):89\u2013101.","journal-title":"Endocrinol Diabetes Nutr (Engl Ed)."},{"issue":"1","key":"2468_CR30","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/SLE.0000000000000844","volume":"31","author":"A Roushdy","year":"2021","unstructured":"Roushdy A, Abdel-Razik MA, Emile SH, Farid M, Elbanna HG, Khafagy W, et al. Fasting ghrelin and postprandial GLP-1 levels in patients with morbid obesity and medical comorbidities after sleeve gastrectomy and one-anastomosis gastric bypass: a randomized clinical trial. Surg Laparosc Endosc Percutan Tech. 2021;31(1):28\u201335.","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"2468_CR31","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s11695-018-3498-z","volume":"29","author":"A Itlaybah","year":"2019","unstructured":"Itlaybah A, Elbanna H, Emile S, Thabet W, Elkashef W, Abdelsalam N, et al. Correlation between the number of ghrelin-secreting cells in the gastric fundus and excess weight loss after sleeve gastrectomy. Obes Surg. 2019;29:76\u201383.","journal-title":"Obes Surg"},{"issue":"3","key":"2468_CR32","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1056\/NEJM200401153500323","volume":"350","author":"G Fr\u00fchbeck","year":"2004","unstructured":"Fr\u00fchbeck G, Caballero AD, Gil MJ. Fundus functionality and ghrelin concentrations after bariatric surgery. N Engl J Med. 2004;350(3):308\u20139.","journal-title":"N Engl J Med."},{"key":"2468_CR33","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s00423-015-1315-x","volume":"400","author":"T Yigit","year":"2015","unstructured":"Yigit T, Coskun AK, Harlak A, Sinan H, Unlu A, Tapan S, et al. Body mass index and ghrelin levels after laparoscopic Nissen fundoplication. Langenbecks Arch Surg. 2015;400:585\u20138.","journal-title":"Langenbecks Arch Surg"},{"issue":"2","key":"2468_CR34","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/j.1572-0241.2000.01760.x","volume":"95","author":"T Kamolz","year":"2000","unstructured":"Kamolz T, Bammer T, Pointner R. Predictability of dysphagia after laparoscopic Nissen fundoplication. Am J Gastroenterol. 2000;95(2):408\u201314.","journal-title":"Am J Gastroenterol"},{"key":"2468_CR35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00464-004-9006-7","volume":"19","author":"C Neumayer","year":"2005","unstructured":"Neumayer C, Ciovica R, Gadenst\u00e4tter M, Erd G, Leidl S, Lehr S, et al. Significant weight loss after laparoscopic Nissen fundoplication. Surg Endosc. 2005;19:15\u201320.","journal-title":"Surg Endosc."}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-024-02468-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12893-024-02468-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-024-02468-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:04:04Z","timestamp":1717574644000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-024-02468-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2468"],"URL":"https:\/\/doi.org\/10.1186\/s12893-024-02468-2","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,5]]},"assertion":[{"value":"1 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by the Ethical Research Committee of the People\u2019s Hospital of Xinjiang Uyghur Autonomous Region, Urumqi (Approval no.2020041007). Informed consent was obtained from all patients for the publication of their clinical data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The data that support the findings of this study are available from the authors but restrictions apply to the availability of these data, which were used under license from the People\u2019s Hospital of Xinjiang Autonomous Region for the current study, and so are not publicly available. Data are, however, available from the authors upon reasonable request and with permission from the Information Center of People\u2019s Hospital of Xinjiang Autonomous Region. If someone wants to request the data from this study, they should contact the corresponding author.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Materials availability"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}],"article-number":"176"}}