{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:40:18Z","timestamp":1774039218178,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Beijing Hospital Authority\u2019s Ascent Plan","award":["FFL2022110"],"award-info":[{"award-number":["FFL2022110"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2020-2-2103"],"award-info":[{"award-number":["2020-2-2103"]}]},{"name":"Research Unit of Minimally Invasive Pediatric Surgery on Diagnosis and Treatment, Chinese Academy of Medical Sciences","award":["2021RU015"],"award-info":[{"award-number":["2021RU015"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Matrix metalloproteinase-7 (MMP-7) is associated with biliary injury. This study aimed to evaluate the relationships of serum MMP-7 with clinical characteristics in choledochal cysts (CDC) children.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Between June 2020 and July 2022, we conducted a prospective study of CDCs who underwent one-stage definitive operation at our center. Serum MMP-7 was measured using an enzyme-linked immunosorbent assay. We evaluated the relationships between serum MMP-7 and age, laboratory tests, imaging examinations, liver fibrosis, MMP-7 expression, and perforation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 328 CDCs were enrolled in the study, with a median serum MMP-7 of 7.67 ng\/mL. Higher serum MMP-7 was correlated with younger age at diagnosis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), larger cyst sizes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), higher liver fibrosis stages (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and higher incidence of perforation (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.01). Liver MMP-7 was mainly expressed in intrahepatic and extrahepatic biliary epithelial cells. The area under the receiver operating characteristic curve (AUROC) was 0.630 (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.001) for serum MMP-7 in predicting perforation. When serum MMP-7 was combined with \u03b3-glutamyl transferase (GGT), the AUROC increased to 0.706 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Serum MMP-7 was associated with biliary obstruction in CDCs. Patients with high serum MMP-7 were more likely to have severe liver damage and biliary injury, with higher incidences of liver fibrosis and perforation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12893-024-02488-y","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:02:05Z","timestamp":1719223325000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationships of serum MMP-7 and clinical characteristics in choledochal cyst children"],"prefix":"10.1186","volume":"24","author":[{"given":"Tong","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"2488_CR1","doi-asserted-by":"publisher","unstructured":"Jablonska B. Biliary cysts: etiology, diagnosis and management. World J Gastroenterol. 2012, 18(35): 4801\u201310. https:\/\/doi.org\/10.3748\/wjg.v18.i35.4801.","DOI":"10.3748\/wjg.v18.i35.4801"},{"issue":"1","key":"2488_CR2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3348\/kjr.2009.10.1.71","volume":"10","author":"LEE H K","year":"2009","unstructured":"Lee H K, Park S J, Yi B H, LEE A L, Moon J H. Chang Y W. Imaging features of adult choledochal cysts: a pictorial review. Korean J Radiol. 2009;10(1):71\u201380. https:\/\/doi.org\/10.3348\/kjr.2009.10.1.71.","journal-title":"Korean J Radiol"},{"issue":"4","key":"2488_CR3","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s002610000184","volume":"26","author":"M SATO","year":"2001","unstructured":"Sato M, Ishida H, Konno K, Naganuma H, Ishida J, Hirata M, Yamada N, Watanabe S. Choledochal cyst due to anomalous pancreatobiliary junction in the adult: sonographic findings. Abdom Imaging. 2001;26(4):395\u2013400. https:\/\/doi.org\/10.1007\/s002610000184.","journal-title":"Abdom Imaging"},{"issue":"3","key":"2488_CR4","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jpedsurg.2011.09.056","volume":"47","author":"M DIAO","year":"2012","unstructured":"Diao M, Li L, Cheng W. Timing of surgery for prenatally diagnosed asymptomatic choledochal cysts: a prospective randomized study. J Pediatr Surg. 2012;47(3):506\u201312. https:\/\/doi.org\/10.1016\/j.jpedsurg.2011.09.056.","journal-title":"J Pediatr Surg"},{"key":"2488_CR5","doi-asserted-by":"publisher","unstructured":"Raeeszadeh-Sarmazdeh M, DO L D, HRITZ BG. Metalloproteinases and their inhibitors: potential for the development of new therapeutics. Cells. 2020;9(5). https:\/\/doi.org\/10.3390\/cells9051313.","DOI":"10.3390\/cells9051313"},{"key":"2488_CR6","doi-asserted-by":"publisher","unstructured":"Nomden M, Verkade H J Beljaarsl, Hulscher J B F Olingap. Current concepts of biliary atresia and Matrix Metalloproteinase-7: a review of literature. Front Med (Lausanne). 2020;7(617261). https:\/\/doi.org\/10.3389\/fmed.2020.617261.","DOI":"10.3389\/fmed.2020.617261"},{"issue":"7","key":"2488_CR7","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/modpathol.3800374","volume":"18","author":"MH HUANG C C, CHUANG J H, CHOU M H, WU","year":"2005","unstructured":"Huang C C, Chuang J H, Chou M H, Wu C L, Chen C M, Wang C C, Chen Y S, Chen C L, Tai Mh. Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis. Mod Pathol. 2005;18(7):941\u201350. https:\/\/doi.org\/10.1038\/modpathol.3800374.","journal-title":"Mod Pathol"},{"key":"2488_CR8","doi-asserted-by":"publisher","unstructured":"Lertudomphonwanit C, Mourya R, Fei L, Zhang Y, Gutta S, Yang L, Bove K E. Shivakumar P, Bezerra J A. large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia. Sci Transl Med. 2017;9(417). https:\/\/doi.org\/10.1126\/scitranslmed.aan8462.","DOI":"10.1126\/scitranslmed.aan8462"},{"issue":"5","key":"2488_CR9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/hepr.13753","volume":"52","author":"H SAKAGUCHI","year":"2022","unstructured":"Sakaguchi H, Konishi K I, Yasuda R, Sasaki H, Yoshimaru K, Tainaka T, Fukahori S, Sanada Y, Iwama I, Shoji H, Kinoshita M, Matsuura T, Fujishiro J, Uchida H, Nio M, Yamashita Y, Mizuochi T. Serum matrix metalloproteinase-7 in biliary atresia: a Japanese multicenter study. Hepatol Research: Official J Japan Soc Hepatol. 2022;52(5):479\u201387. https:\/\/doi.org\/10.1111\/hepr.13753.","journal-title":"Hepatol Research: Official J Japan Soc Hepatol"},{"issue":"11","key":"2488_CR10","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1053\/jpsu.2001.27932","volume":"36","author":"L LI","year":"2001","unstructured":"Li L, Yamataka A, Yian-Xia W, Da-Yong W, Segawa O Lanegj, Jin-Zhe Z Kunw, Miyano T. Ectopic distal location of the papilla of vater in congenital biliary dilatation: implications for pathogenesis. J Pediatr Surg. 2001;36(11):1617\u201322. https:\/\/doi.org\/10.1053\/jpsu.2001.27932.","journal-title":"J Pediatr Surg"},{"issue":"1","key":"2488_CR11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00383-023-05486-y","volume":"39","author":"S CHEN","year":"2023","unstructured":"Chen S, Yin T, Li L, Diao M, Huang T. Correlation of ectopic distal location of papilla of Vater and clinical characteristics in pediatric choledochal cysts. Pediatr Surg Int. 2023;39(1):201. https:\/\/doi.org\/10.1007\/s00383-023-05486-y.","journal-title":"Pediatr Surg Int"},{"issue":"12","key":"2488_CR12","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1097\/00000478-199512000-00007","volume":"19","author":"LUDWIGJ BATTS K P","year":"1995","unstructured":"Batts K P Ludwigj. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol. 1995;19(12):1409\u201317. https:\/\/doi.org\/10.1097\/00000478-199512000-00007.","journal-title":"Am J Surg Pathol"},{"issue":"44","key":"2488_CR13","doi-asserted-by":"publisher","first-page":"77241","DOI":"10.18632\/oncotarget.20455","volume":"8","author":"G MAO X W, XIAO J Q, XU","year":"2017","unstructured":"Mao X W, Xiao J Q, Xu G, Li Z Y, Wu H F, Li Y, Zheng Y C, Zhang N. CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt\/\u03b2-catenin signaling pathway. Oncotarget. 2017;8(44):77241\u201353. https:\/\/doi.org\/10.18632\/oncotarget.20455.","journal-title":"Oncotarget"},{"issue":"18","key":"2488_CR14","doi-asserted-by":"publisher","first-page":"10830","DOI":"10.1111\/jcmm.15708","volume":"24","author":"C YANG","year":"2020","unstructured":"Yang C, Shi S, Su Y, Tong J S Lil. P2X7R promotes angiogenesis and tumour-associated macrophage recruitment by regulating the NF-\u03baB signalling pathway in colorectal cancer cells. J Cell Mol Med. 2020;24(18):10830\u201341. https:\/\/doi.org\/10.1111\/jcmm.15708.","journal-title":"J Cell Mol Med"},{"issue":"12","key":"2488_CR15","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1016\/j.jpedsurg.2011.09.017","volume":"46","author":"J FUJISHIRO","year":"2011","unstructured":"Fujishiro J, Urita Y, Shinkai T, Gotoh C, Hoshino N, Ono K, Komuro H. Clinical characteristics of liver fibrosis in patients with choledochal cysts. J Pediatr Surg. 2011;46(12):2296\u2013300. https:\/\/doi.org\/10.1016\/j.jpedsurg.2011.09.017.","journal-title":"J Pediatr Surg"},{"issue":"4","key":"2488_CR16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/jpc.13779","volume":"54","author":"J TANG","year":"2018","unstructured":"Tang J, Zhang D, Liu W, Zeng J X, Yu J K, Gao Y. Differentiation between cystic biliary atresia and choledochal cyst: a retrospective analysis. J Paediatr Child Health. 2018;54(4):383\u20139. https:\/\/doi.org\/10.1111\/jpc.13779.","journal-title":"J Paediatr Child Health"},{"key":"2488_CR17","doi-asserted-by":"publisher","unstructured":"Wu JF, Jeng YM, Chen HL, Ni YH, Hsu HY, Chang MH. Quantification of serum Matrix Metallopeptide 7 levels may assist in the diagnosis and predict the outcome for patients with biliary atresia. J Pediatr. 2019;208(30\u20137e1). https:\/\/doi.org\/10.1016\/j.jpeds.2018.12.006.","DOI":"10.1016\/j.jpeds.2018.12.006"},{"issue":"2","key":"2488_CR18","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1002\/hep.30902","volume":"71","author":"M DIAO","year":"2020","unstructured":"Diao M, Li L. Timing of Choledochal Cyst Perforation. Hepatology. 2020;71(2):753\u20136. https:\/\/doi.org\/10.1002\/hep.30902.","journal-title":"Hepatology"},{"issue":"9","key":"2488_CR19","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/jhbp.1158","volume":"29","author":"S KATO","year":"2022","unstructured":"Kato S, Kaneko K, Matsushita N, Saito T, Fukami Y, Komatsu S. Prenatally diagnosed biliary cysts: a spectrum from congenital biliary dilatation to biliary atresia from the same origin. J Hepatobiliary Pancreat Sci. 2022;29(9):961\u20133. https:\/\/doi.org\/10.1002\/jhbp.1158.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"12","key":"2488_CR20","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/0022-3468(94)90224-0","volume":"29","author":"CHAMBERLAINP TSANG T M, TAM P K H","year":"1994","unstructured":"Tsang T M, Tam P K H Chamberlainp. Obliteration of the distal bile duct in the development of congenital choledochal cyst. J Pediatr Surg. 1994;29(12):1582.","journal-title":"J Pediatr Surg"},{"issue":"8","key":"2488_CR21","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.jpedsurg.2010.12.022","volume":"46","author":"M DIAO","year":"2011","unstructured":"Diao M, LI L, Cheng W. Congenital biliary dilatation may consist of 2 disease entities. J Pediatr Surg. 2011;46(8):1503\u20139. https:\/\/doi.org\/10.1016\/j.jpedsurg.2010.12.022.","journal-title":"J Pediatr Surg"},{"key":"2488_CR22","doi-asserted-by":"publisher","unstructured":"Spitz L. Experimental production of cystic dilatation of the common bile duct in neonatal lambs. J Pediatr Surg. 1977, 12(1): 39\u201342. https:\/\/doi.org\/10.1016\/0022-3468(77)90293-7.","DOI":"10.1016\/0022-3468(77)90293-7"},{"key":"2488_CR23","doi-asserted-by":"publisher","unstructured":"Spitz L. Ligation of the common bile duct in the fetal lamb: an experimental model for the study of biliary atresia. Pediatr Res. 1980, 14(5): 740\u20138. https:\/\/doi.org\/10.1203\/00006450-198005000-00007.","DOI":"10.1203\/00006450-198005000-00007"},{"issue":"6","key":"2488_CR24","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/ar.20710","volume":"291","author":"T ROSKAMS","year":"2008","unstructured":"Roskams T. Embryology of extra- and intrahepatic bile ducts, the ductal plate. Anat Rec (Hoboken). 2008;291(6):628\u201335. https:\/\/doi.org\/10.1002\/ar.20710.","journal-title":"Anat Rec (Hoboken)"},{"issue":"2","key":"2488_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1242\/dmm.012062","volume":"7","author":"M GIANNANDREA","year":"2014","unstructured":"Giannandrea M, Parks WC. Diverse functions of matrix metalloproteinases during fibrosis. Dis Model Mech. 2014;7(2):193\u2013203. https:\/\/doi.org\/10.1242\/dmm.012062.","journal-title":"Dis Model Mech"},{"issue":"12","key":"2488_CR26","doi-asserted-by":"publisher","first-page":"905","DOI":"10.47102\/annals-acadmedsg.V35N12p905","volume":"35","author":"T PRASAD","year":"2006","unstructured":"Prasad T, Chan H C, Low Y, Chong C L. Jacobsen A S. bile duct perforation in children: is it truly spontaneous? Ann Acad Med Singap. 2006;35(12):905\u20138.","journal-title":"Ann Acad Med Singap"},{"issue":"2","key":"2488_CR27","first-page":"125","volume":"181","author":"H ANDO","year":"1995","unstructured":"Ando H, ITO T, Watanabe Y, Seo T, Kaneko K. Spontaneous perforation of choledochal cyst. J Am Coll Surg. 1995;181(2):125\u20138.","journal-title":"J Am Coll Surg"},{"issue":"4","key":"2488_CR28","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1007\/s12072-022-10322-x","volume":"16","author":"S CHI","year":"2022","unstructured":"Chi S, Xu P, Yu P, Cao G, Wang H, Ye Y, Li S, Zhou Y, Li X, Zhou Y, Zhang X, Niu H, Xu L, Cai P, Tang S. Dynamic analysis of serum MMP-7 and its relationship with disease progression in biliary atresia: a multicenter prospective study. Hep Intl. 2022;16(4):954\u201363. https:\/\/doi.org\/10.1007\/s12072-022-10322-x.","journal-title":"Hep Intl"},{"issue":"3","key":"2488_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/cjp2.50","volume":"2","author":"A KEROLA","year":"2016","unstructured":"Kerola A, Lampela H, Lohi J, Heikkil\u00e4 P, Mutanen A, Hagstr\u00f6m J, Tervahartiala T, Sorsa T, Haglund C, Jalanko H. Pakarinen M P. increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia. J Pathol Clin Res. 2016;2(3):187\u201398. https:\/\/doi.org\/10.1002\/cjp2.50.","journal-title":"J Pathol Clin Res"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-024-02488-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12893-024-02488-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-024-02488-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:04:25Z","timestamp":1719223465000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcsurg.biomedcentral.com\/articles\/10.1186\/s12893-024-02488-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2488"],"URL":"https:\/\/doi.org\/10.1186\/s12893-024-02488-y","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,24]]},"assertion":[{"value":"18 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki). The study was approved by Ethical Committee of Capital Institute of Pediatrics (shell2022047), and informed consent was obtained from all subjects and their legal guardian(s)\/parents.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"195"}}