{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T23:53:02Z","timestamp":1769644382122,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYAI24064"],"award-info":[{"award-number":["ZYAI24064"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Surg"],"DOI":"10.1186\/s12893-025-03450-2","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:04:29Z","timestamp":1766729069000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["En bloc resection for extra-nodal Rosai-Dorfman disease in the anterior mediastinum: a case report"],"prefix":"10.1186","volume":"26","author":[{"given":"Ling","family":"You","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanlin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"3450_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41572-021-00307-9","volume":"7","author":"KL McClain","year":"2021","unstructured":"McClain KL, Bigenwald C, Collin M, Haroche J, Marsh RA, Merad M, et al. Histiocytic disorders. Nat Rev Dis Primers. 2021;7:73.","journal-title":"Nat Rev Dis Primers"},{"key":"3450_CR2","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1513\/AnnalsATS.201510-703BC","volume":"13","author":"ST Apperley","year":"2016","unstructured":"Apperley ST, Hyjek EM, Musani R, Thenganatt J. Intrathoracic rosai Dorfman disease with focal aggregates of IgG4-bearing plasma Cells. Case report and literature review. Ann Am Thorac Soc. 2016;13:666\u201370.","journal-title":"Ann Am Thorac Soc"},{"key":"3450_CR3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1378\/chest.86.2.266","volume":"86","author":"MJ Friedman","year":"1984","unstructured":"Friedman MJ, Rossoff LJ, Aftalion B, Khan A, Decker R, Steinberg H. Sinus histiocytosis presenting as a mediastinal mass. Chest. 1984;86:266\u20137.","journal-title":"Chest"},{"key":"3450_CR4","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1440-1827.2009.02362.x","volume":"59","author":"AI Hida","year":"2009","unstructured":"Hida AI, Yagi S, Obase Y, Nishimura H, Akiyama T, Irei I, et al. Rosai-Dorfman disease presenting as a solitary mediastinal mass. Pathol Int. 2009;59:265\u20138.","journal-title":"Pathol Int"},{"key":"3450_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.arbres.2010.10.010","volume":"47","author":"T Ozlu","year":"2011","unstructured":"Ozlu T, Bulbul Y, Erol MM. A rare cause of mediastinal enlargement: sinus histiocytosis with massive lymphadenopathy. Arch Bronconeumol. 2011;47:161\u20132.","journal-title":"Arch Bronconeumol"},{"key":"3450_CR6","first-page":"275","volume":"32","author":"J de Goupil","year":"2015","unstructured":"de Goupil J, de Muret A, Diot E, Dumont P, Plantier L, Diot P, et al. Pulmonary manifestations revealing Rosai-Dorfman disease. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32:275\u20137.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"3450_CR7","doi-asserted-by":"publisher","first-page":"e2821","DOI":"10.1097\/MD.0000000000002821","volume":"95","author":"L Boissi\u00e8re","year":"2016","unstructured":"Boissi\u00e8re L, Patey M, Toubas O, Vella-Boucaud J, Perotin-Collard JM, Desl\u00e9e G, et al. Tracheobronchial involvement of Rosai-Dorfman disease: case report and review of the literature. Med (Baltim). 2016;95:e2821.","journal-title":"Med (Baltim)"},{"key":"3450_CR8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1158\/2159-8290.CD-15-0913","volume":"6","author":"EL Diamond","year":"2016","unstructured":"Diamond EL, Durham BH, Haroche J, Yao Z, Ma J, Parikh SA, et al. Diverse and targetable kinase alterations drive Histiocytic neoplasms. Cancer Discov. 2016;6:154\u201365.","journal-title":"Cancer Discov"},{"key":"3450_CR9","doi-asserted-by":"publisher","first-page":"e89473","DOI":"10.1172\/jci.insight.89473","volume":"2","author":"LH Lee","year":"2017","unstructured":"Lee LH, Gasilina A, Roychoudhury J, Clark J, McCormack FX, Pressey J, et al. Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes. JCI Insight. 2017;2:e89473.","journal-title":"JCI Insight"},{"key":"3450_CR10","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/modpathol.2017.55","volume":"30","author":"S Garces","year":"2017","unstructured":"Garces S, Medeiros LJ, Patel KP, Li S, Pina-Oviedo S, Li J, et al. Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease. Mod Pathol. 2017;30:1367\u201377.","journal-title":"Mod Pathol"},{"key":"3450_CR11","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1182\/blood-2018-03-839753","volume":"131","author":"O Abla","year":"2018","unstructured":"Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile JF, et al. Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood. 2018;131:2877\u201390.","journal-title":"Blood"},{"key":"3450_CR12","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.6004\/jnccn.2021.7098","volume":"19","author":"KL Rech","year":"2021","unstructured":"Rech KL, He R. Challenges in the histopathologic diagnosis of Histiocytic neoplasms. J Natl Compr Canc Netw. 2021;19:1305\u201311.","journal-title":"J Natl Compr Canc Netw"},{"key":"3450_CR13","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","volume":"127","author":"JF Emile","year":"2016","unstructured":"Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127:2672\u201381.","journal-title":"Blood"},{"key":"3450_CR14","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1016\/S0140-6736(14)60720-0","volume":"385","author":"T Kamisawa","year":"2015","unstructured":"Kamisawa T, Zen Y, Pillai S, Stone JH. IgG4-related disease. Lancet. 2015;385:1460\u201371.","journal-title":"Lancet"},{"key":"3450_CR15","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/0046-8177(92)90320-3","volume":"23","author":"M Paulli","year":"1992","unstructured":"Paulli M, Rosso R, Kindl S, Boveri E, Marocolo D, Chioda C, et al. Immunophenotypic characterization of the cell infiltrate in five cases of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Hum Pathol. 1992;23:647\u201354.","journal-title":"Hum Pathol"},{"key":"3450_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ajh.10008","volume":"69","author":"A Pulsoni","year":"2002","unstructured":"Pulsoni A, Anghel G, Falcucci P, Matera R, Pescarmona E, Ribersani M, et al. Treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case and literature review. Am J Hematol. 2002;69:67\u201371.","journal-title":"Am J Hematol"},{"key":"3450_CR17","first-page":"937","volume":"93","author":"F Forest","year":"2014","unstructured":"Forest F, N\u2019Guyen AT, Fesselet J, Metellus P, Bouvier C, de Paula AM, et al. Meningeal Rosai-Dorfman disease mimicking meningioma. Ann Hematol. 2014;93:937\u201340.","journal-title":"Ann Hematol"},{"key":"3450_CR18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.prp.2005.11.004","volume":"202","author":"WJ Z\u2019Graggen","year":"2006","unstructured":"Z\u2019Graggen WJ, Sturzenegger M, Mariani L, Keserue B, Kappeler A, Vajtai I. Isolated Rosai-Dorfman disease of intracranial meninges. Pathol Res Pract. 2006;202:165\u201370.","journal-title":"Pathol Res Pract"},{"key":"3450_CR19","first-page":"211","volume":"19","author":"O Sakallioglu","year":"2006","unstructured":"Sakallioglu O, Gok F, Kalman S, Atay AA, Kaya A, Duzova A, et al. Minimal change nephropathy in a 7-year-old Boy with Rosai-Dorfman disease. J Nephrol. 2006;19:211\u20134.","journal-title":"J Nephrol"},{"key":"3450_CR20","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1056\/NEJMc1713676","volume":"377","author":"E Jacobsen","year":"2017","unstructured":"Jacobsen E, Shanmugam V, Jagannathan J. Rosai-Dorfman disease with activating KRAS Mutation - Response to Cobimetinib. N Engl J Med. 2017;377:2398\u201399.","journal-title":"N Engl J Med"}],"container-title":["BMC Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12893-025-03450-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-025-03450-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12893-025-03450-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:30:50Z","timestamp":1769599850000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12893-025-03450-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3450"],"URL":"https:\/\/doi.org\/10.1186\/s12893-025-03450-2","relation":{},"ISSN":["1471-2482"],"issn-type":[{"value":"1471-2482","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"10 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee on Biomedical Research, West China Hospital of Sichuan University (2022\u2009\u2212\u20091758), and informed consent was obtained from the participant.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of both Case 1 and Case 2\u00a0s clinical details and\/or clinical images was obtained directly from both of the patients. A copy of this consent to publish is available for review by the editor of the journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"83"}}