{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:18:51Z","timestamp":1772165931248,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Urol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The presence of urinary fistula after ileal conduit urinary diversion is a challenging complication, and this study investigated the role of the intra-conduit negative pressure system (NPS) in the presence of urinary fistula following ileal conduit (IC) urinary diversion as a conservative treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the intra-conduit NPS, a minor drainage tube was placed within a silicon tube to suck urine from the conduit with consistent negative pressure. Patients with urinary fistula following IC from August 2012 to July 2017 were recorded, and the clinical characteristics and outcome were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The intra-conduit NPS was used as a primarily conservative treatment for 13 patients who suffered from urinary fistula and presented with a large amount of abdominal\/pelvic drainage without other significant morbidities. The median age was 60\u2009years old (42\u201374\u2009years), and 7patients were male. The median duration between the IC operation and the presence of urinary fistula was 15\u2009days (2\u201328\u2009days), and elevated creatinine levels were detected in the abdominal\/pelvic drainage with a median level of 2114\u2009\u03bcmol\/L (636\u2013388\u2009\u03bcmol\/L). A significant decrease in abdominal\/pelvic drainage was identified in 12 patients. The median time that the NPS was used was 9\u2009days (7\u201311\u2009days). The other patient did not show any improvements after 2\u2009days of observation and then underwent open surgery. With ureteral stenting, 2 abdominal drainage tubes and the intra-conduit NPS were placed during operation, no urine leakage was observed in the abdominal\/pelvic field, and the patient was cured in 9\u2009days. With a median follow-up of 22\u2009months, no fistula recurrence or hydronephrosis was detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The intra-conduit negative pressure system is a feasible and promising way to cure urinary fistula following ileal conduit urinary diversion. Because this procedure is a mini-invasive and simple approach, it might represent an alternative in selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12894-019-0564-3","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T10:04:49Z","timestamp":1575972289000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Conservative treatment for urinary fistula following ileal conduit urinary diversion: a simple method"],"prefix":"10.1186","volume":"19","author":[{"given":"Yun-lin","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-tao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang-hua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7346-0305","authenticated-orcid":false,"given":"Zi-ke","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"564_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.eururo.2014.12.007","volume":"67","author":"G Novara","year":"2015","unstructured":"Novara G, Catto JW, Wilson T, et al. Systematic review and cumulative analysis of perioperative outcomes and complications after robot-assisted radical cystectomy. Eur Urol. 2015;67:376\u2013401.","journal-title":"Eur Urol"},{"key":"564_CR2","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.eururo.2014.11.043","volume":"67","author":"BH Bochner","year":"2015","unstructured":"Bochner BH, Dalbagni G, Sjoberg DD, et al. Comparing open radical cystectomy and robot-assisted laparoscopic radical cystectomy: a randomized clinical trial. Eur Urol. 2015;67:1042\u201350.","journal-title":"Eur Urol"},{"key":"564_CR3","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.juro.2018.10.006","volume":"201","author":"NJ Sathianathen","year":"2019","unstructured":"Sathianathen NJ, Kalapara A, Frydenberg M, et al. Robotic assisted radical cystectomy vs open radical cystectomy: systematic review and meta-analysis. J Urol. 2019;201:715\u201320.","journal-title":"J Urol"},{"key":"564_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/bju.12121","volume":"113","author":"RK Lee","year":"2014","unstructured":"Lee RK, Abol-Enein H, Artibani W, et al. Urinary diversion after radical cystectomy for bladder cancer: options, patient selection, and outcomes. BJU Int. 2014;113:11\u201323.","journal-title":"BJU Int"},{"key":"564_CR5","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.suc.2016.02.012","volume":"96","author":"HS Gill","year":"2016","unstructured":"Gill HS. Diagnosis and surgical management of uroenteric fistula. Surg Clin North Am. 2016;96:583\u201392.","journal-title":"Surg Clin North Am"},{"key":"564_CR6","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1055\/a-0581-5533","volume":"190","author":"D Kuetting","year":"2018","unstructured":"Kuetting D, Pieper CC. Percutaneous treatment options of lower urinary tract fistulas and leakages. Rofo. 2018;190:692\u2013700.","journal-title":"Rofo."},{"key":"564_CR7","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.ejso.2013.09.024","volume":"40","author":"KG Brown","year":"2014","unstructured":"Brown KG, Koh CE, Vasilaras A, Eisinger D, Solomon MJ. Clinical algorithms for the diagnosis and management of urological leaks following pelvic exenteration. Eur J Surg Oncol. 2014;40:775\u201381.","journal-title":"Eur J Surg Oncol"},{"key":"564_CR8","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.juro.2017.08.095","volume":"199","author":"ZL Smith","year":"2018","unstructured":"Smith ZL, Johnson SC, Golan S, McGinnis JR, Steinberg GD, Smith ND. Fistulous complications following radical cystectomy for bladder cancer: analysis of a large modern cohort. J Urol. 2018;199:663\u20138.","journal-title":"J Urol"},{"key":"564_CR9","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.juro.2007.11.083","volume":"179","author":"L Msezane","year":"2008","unstructured":"Msezane L, Reynolds WS, Mhapsekar R, Gerber G, Steinberg G. Open surgical repair of ureteral strictures and fistulas following radical cystectomy and urinary diversion. J Urol. 2008;179:1428\u201331.","journal-title":"J Urol"},{"key":"564_CR10","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1089\/end.2017.0271","volume":"31","author":"L Olson","year":"2017","unstructured":"Olson L, Satherley H, Cleaveland P, et al. Retrograde endourological management of upper urinary tract abnormalities in patients with Ileal conduit urinary diversion: a dual-center experience. J Endourol. 2017;31:841\u20136.","journal-title":"J Endourol"},{"key":"564_CR11","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1089\/end.2012.0371","volume":"27","author":"RE Stuurman","year":"2013","unstructured":"Stuurman RE, Al-Qahtani SM, Cornu JN, Traxer O. Antegrade percutaneous flexible endoscopic approach for the management of urinary diversion-associated complications. J Endourol. 2013;27:1330\u20134.","journal-title":"J Endourol"},{"issue":"1","key":"564_CR12","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12893-017-0281-3","volume":"17","author":"G Montori","year":"2017","unstructured":"Montori G, Allievi N, Coccolini F, et al. Negative pressure wound therapy versus modified barker vacuum pack as temporary abdominal closure technique for open abdomen management: a four-year experience. BMC Surg. 2017;17(1):86.","journal-title":"BMC Surg"},{"key":"564_CR13","doi-asserted-by":"crossref","unstructured":"Driver VR, Eckert KA, Carter MJ, French MA. Cost-effectiveness of negative pressure wound therapy in patients with many comorbidities and severe wounds of various etiology. Wound Repair Regen. 2016:241041\u201358.","DOI":"10.1111\/wrr.12483"},{"key":"564_CR14","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1002\/bjs.9636","volume":"101","author":"GE Glass","year":"2014","unstructured":"Glass GE, Murphy GF, Esmaeili A, Lai LM, Nanchahal J. Systematic review of molecular mechanism of action of negative-pressure wound therapy. Br J Surg. 2014;101:1627\u201336.","journal-title":"Br J Surg"},{"key":"564_CR15","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ijscr.2014.04.030","volume":"5","author":"F Yetisir","year":"2014","unstructured":"Yetisir F, Salman AE, Aygar M, Yaylak F, Aksoy M, Yalcin A. Management of fistula of ileal conduit in open abdomen by intra-condoit negative pressure system. Int J Surg Case Rep. 2014;5:385\u20138.","journal-title":"Int J Surg Case Rep"},{"key":"564_CR16","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/WON.0b013e3182a46549","volume":"40","author":"JJ Freeman","year":"2013","unstructured":"Freeman JJ, Storto DL, Berry-Caban CS. Repair of a vesicocutaneous fistula using negative-pressure wound therapy and urinary diversion via a nephrostomy tube. J Wound Ostomy Continence Nurs. 2013;40:536\u20138.","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"564_CR17","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1111\/j.1600-6143.2010.03237.x","volume":"10","author":"S Heap","year":"2010","unstructured":"Heap S, Mehra S, Tavakoli A, Augustine T, Riad H, Pararajasingam R. Negative pressure wound therapy used to heal complex urinary fistula wounds following renal transplantation into an ileal conduit. Am J Transplant. 2010;10:2370\u20133.","journal-title":"Am J Transplant"},{"key":"564_CR18","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.juro.2015.02.2964","volume":"194","author":"NH Asvadi","year":"2015","unstructured":"Asvadi NH, Arellano RS. Transrenal antegrade ureteral occlusion: clinical assessment of indications, technique and outcomes. J Urol. 2015;194:1428\u201332.","journal-title":"J Urol"},{"key":"564_CR19","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1464-410X.2006.06522.x","volume":"99","author":"V Natarajan","year":"2007","unstructured":"Natarajan V, Boucher NR, Meiring P, Spencer P, Parys BT, Oakley NE, Stent (Society for Endourology in North Trent) Group. Ureteric embolization: an alternative treatment strategy for urinary fistulae complicating advanced pelvic malignancy. BJU Int. 2007;99:147\u20139.","journal-title":"BJU Int"},{"key":"564_CR20","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1159\/000020340","volume":"38","author":"S Horenblas","year":"2000","unstructured":"Horenblas S, Kroger R, van Boven E, Meinhardt W, Newling DW. Use of balloon catheters for ureteral occlusion in urinary leakage. Eur Urol. 2000;38:613\u20137.","journal-title":"Eur Urol"},{"key":"564_CR21","first-page":"5397","volume":"17","author":"JC Forde","year":"2010","unstructured":"Forde JC, O'Connor KM, Fanning DM, Guiney MJ, Lynch TH. Management of a persistent ileo-ureteric anastomotic leak with bilateral ureteric occlusion using angioplasty balloon catheters. Can J Urol. 2010;17:5397\u2013400.","journal-title":"Can J Urol"}],"container-title":["BMC Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12894-019-0564-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12894-019-0564-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12894-019-0564-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T20:16:16Z","timestamp":1607458576000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcurol.biomedcentral.com\/articles\/10.1186\/s12894-019-0564-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["564"],"URL":"https:\/\/doi.org\/10.1186\/s12894-019-0564-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.11352\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.2.11352\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.2.11352\/v3","asserted-by":"object"}]},"ISSN":["1471-2490"],"issn-type":[{"value":"1471-2490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"7 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the ethics committee of Sun Yat-sen University Cancer Center (YP2008063). Informed consent was obtained from all individual participants included in the study. Consent to participate was acquired in written format.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"131"}}