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SCCB is very aggressive and always mixed with other histologic components, but coexistence of SCCB and prostate adenocarcinoma is extremely rare.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Cases presentation<\/jats:title>\n<jats:p>Two aged males (72 and 58\u2009years) were included in this study. Both of them presented with gross hematuria as initial symptom. Magnetic resonance imaging (MRI) demonstrated protruding lesions in the urinary bladder. Pathological examination after radical cystectomy and prostatectomy showed the concurrence of SCCB and prostate adenocarcinoma. One patient died of liver and lung metastasis 8 months after surgery, and the other patient was still alive after 19\u2009months of follow-up.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In this paper, we reported two unusual cases of coexistence of SCCB and prostate adenocarcinoma, and reviewed relative literatures with respect to the epidemiology, clinical features, pathologic features, diagnosis, treatment and prognosis of SCCB.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12894-020-00705-3","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T13:03:27Z","timestamp":1598619807000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Small cell carcinoma of the bladder with coexisting prostate adenocarcinoma: two cases report and literature review"],"prefix":"10.1186","volume":"20","author":[{"given":"Yanxia","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-5707","authenticated-orcid":false,"given":"Qiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"issue":"1","key":"705_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1148\/rg.351140050","volume":"35","author":"AV Berniker","year":"2015","unstructured":"Berniker AV, Abdulrahman AA, Teytelboym OM, Galindo LM, Mackey JE. 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