{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:17:56Z","timestamp":1784945876530,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Urol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>In definitive radiation therapy for prostate cancer, the SpaceOAR\u00ae System, a hydrogel spacer, is widely used to decrease the irradiated dose and toxicity of rectum. On the other hand, periprostatic abscesses formation and rectal perforation are known as rare adverse effects of SpaceOAR. Nevertheless, there is a lack of reports clarifying the association between aggravation of abscesses and radiation therapy, and hyperbaric oxygen therapy (HBOT) is effective for a peri-SpaceOAR abscess and rectal perforation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a case of a 78-year-old high-risk prostate cancer patient. After SpaceOAR insertion into the correct space, he started to receive external beam radiation therapy (EBRT). He developed a fever, perineal pain and frequent urination after the completion of EBRT, and the magnetic resonance imaging (MRI) revealed a peri-SpaceOAR abscess. Scheduled brachytherapy was postponed, administration of antibiotics and opioid via intravenous drip was commenced, and transperineal drainage was performed. After the alleviation of the abscess, additional EBRT instead of brachytherapy was performed with MRI-guided radiation therapy (MRgRT). On the last day of the MRgRT, perineal pain reoccurred, and MRI and colonoscopy detected the rectal perforation. He received an intravenous antibiotics drip and HBOT, and fully recovered from the rectal perforation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our report indicates that EBRT can lead to a severe rectum complication by causing inflammation for patients with a peri-SpaceOAR abscess. Furthermore, HBOT was effective for the peri-SpaceOAR abscess and rectal perforation associated with EBRT.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12894-020-00767-3","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T13:04:06Z","timestamp":1607951046000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The use of hyperbaric oxygen to treat actinic rectal fistula after SpaceOAR use and radiotherapy for prostate cancer: a case report"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2471-605X","authenticated-orcid":false,"given":"Tairo","family":"Kashihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motokiyo","family":"Komiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shie","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Kikkawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Shima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae","family":"Okuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Igaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arinobu","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Itami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"issue":"3","key":"767_CR1","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.ijrobp.2018.07.184","volume":"102","author":"Z Feng","year":"2018","unstructured":"Feng Z, Rao AD, Cheng Z, et al. Dose prediction model for duodenum sparing with a biodegradable hydrogel spacer for pancreatic cancer radiation therapy. Int J Radiat Oncol Biol Phys. 2018;102(3):651\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"767_CR2","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.ijrobp.2017.08.006","volume":"99","author":"AD Rao","year":"2017","unstructured":"Rao AD, Feng Z, Shin EJ, et al. A novel absorbable radiopaque hydrogel spacer to separate the head of the pancreas and duodenum in radiation therapy for pancreatic cancer. Int J Radiat Oncol Biol Phys. 2017;99(5):1111\u201320.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"767_CR3","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1053\/j.gastro.2019.07.012","volume":"157","author":"T Kerdsirichairat","year":"2019","unstructured":"Kerdsirichairat T, Narang AK, Thompson E, et al. Feasibility of using hydrogel spacers for borderline-resectable and locally advanced pancreatic tumors. Gastroenterology. 2019;157(4):933\u20135.","journal-title":"Gastroenterology"},{"issue":"2","key":"767_CR4","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.brachy.2018.11.003","volume":"18","author":"GM Struik","year":"2019","unstructured":"Struik GM, Pignol JP, Kolkman-Deurloo IK, et al. Subcutaneous spacer injection to reduce skin toxicity in breast brachytherapy: a pilot study on mastectomy specimens. Brachytherapy. 2019;18(2):204\u201310.","journal-title":"Brachytherapy"},{"issue":"1","key":"767_CR5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.radonc.2017.09.017","volume":"126","author":"AD Rao","year":"2018","unstructured":"Rao AD, Coquia S, De Jong R, et al. Effects of biodegradable hydrogel spacer injection on contralateral submandibular gland sparing in radiotherapy for head and neck cancers. Radiother Oncol. 2018;126(1):96\u20139.","journal-title":"Radiother Oncol"},{"issue":"7","key":"767_CR6","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1080\/17434440.2016.1195682","volume":"13","author":"DM Trifiletti","year":"2016","unstructured":"Trifiletti DM, Garda AE, Showalter TN. Implanted spacer approaches for pelvic radiation therapy. Expert Rev Med Devices. 2016;13(7):633\u201340.","journal-title":"Expert Rev Med Devices"},{"issue":"4","key":"767_CR7","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/jrr\/rrz016","volume":"60","author":"T Kashihara","year":"2019","unstructured":"Kashihara T, Murakami N, Tselis N, et al. Hyaluronate gel injection for rectum dose reduction in gynecologic high-dose-rate brachytherapy: initial Japanese experience. J Radiat Res. 2019;60(4):501\u20138.","journal-title":"J Radiat Res"},{"issue":"1","key":"767_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5114\/jcb.2019.82612","volume":"11","author":"N Murakami","year":"2019","unstructured":"Murakami N, Shima S, Kashihara T, et al. Hyaluronic gel injection into the vesicovaginal septum for high-dose-rate brachytherapy of uterine cervical cancer: an effective approach for bladder dose reduction. J Contemp Brachyther. 2019;11(1):1\u20137.","journal-title":"J Contemp Brachyther"},{"issue":"2","key":"767_CR9","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.brachy.2019.11.004","volume":"19","author":"N Murakami","year":"2020","unstructured":"Murakami N, Nakamura S, Kashihara T, et al. Hyaluronic acid gel injection in rectovaginal septum reduced incidence of rectal bleeding in brachytherapy for gynecological malignancies. Brachytherapy. 2020;19(2):154\u201361.","journal-title":"Brachytherapy"},{"issue":"1","key":"767_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s13014-019-1346-5","volume":"14","author":"ME Hwang","year":"2019","unstructured":"Hwang ME, Mayeda M, Liz M, et al. Stereotactic body radiotherapy with periprostatic hydrogel spacer for localized prostate cancer: toxicity profile and early oncologic outcomes. Radiat Oncol. 2019;14(1):136.","journal-title":"Radiat Oncol"},{"issue":"2","key":"767_CR11","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.brachy.2017.10.014","volume":"17","author":"SY Wu","year":"2018","unstructured":"Wu SY, Boreta L, Wu A, et al. Improved rectal dosimetry with the use of SpaceOAR during high-dose-rate brachytherapy. Brachytherapy. 2018;17(2):259\u201364.","journal-title":"Brachytherapy"},{"issue":"5","key":"767_CR12","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.ijrobp.2015.04.030","volume":"92","author":"N Mariados","year":"2015","unstructured":"Mariados N, Sylvester J, Shah D, et al. Hydrogel spacer prospective multicenter randomized controlled pivotal trial: dosimetric and clinical effects of perirectal spacer application in men undergoing prostate image guided intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2015;92(5):971\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"767_CR13","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.ijrobp.2016.12.024","volume":"97","author":"DA Hamstra","year":"2017","unstructured":"Hamstra DA, Mariados N, Sylvester J, et al. Continued benefit to rectal separation for prostate radiation therapy: final results of a phase III trial. Int J Radiat Oncol Biol Phys. 2017;97(5):976\u201385.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"767_CR14","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.ijrobp.2016.12.034","volume":"97","author":"T Shaikh","year":"2017","unstructured":"Shaikh T, Li T, Handorf EA, et al. Long-term patient-reported outcomes from a phase 3 randomized prospective trial of conventional versus hypofractionated radiation therapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2017;97(4):722\u201331.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"767_CR15","doi-asserted-by":"publisher","first-page":"e229143","DOI":"10.1136\/bcr-2018-229143","volume":"12","author":"V Hoe","year":"2019","unstructured":"Hoe V, Yao HH, Huang JG, et al. Abscess formation following hydrogel spacer for prostate cancer radiotherapy: a rare complication. BMJ Case Rep. 2019;12(10):e229143.","journal-title":"BMJ Case Rep"},{"issue":"11","key":"767_CR16","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1001\/jama.280.11.969","volume":"280","author":"AV D'Amico","year":"1998","unstructured":"D\u2019Amico AV, Whittington R, Malkowicz SB, et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA. 1998;280(11):969\u201374.","journal-title":"JAMA"},{"issue":"10162","key":"767_CR17","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1016\/S0140-6736(18)32486-3","volume":"392","author":"CC Parker","year":"2018","unstructured":"Parker CC, James ND, Brawley CD, et al. Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): A randomised controlled phase 3 trial. Lancet. 2018;392(10162):2353\u201366.","journal-title":"Lancet"},{"issue":"5","key":"767_CR18","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1002\/cam4.1408","volume":"7","author":"T Kashihara","year":"2018","unstructured":"Kashihara T, Nakamura S, Wakita A, et al. Importance of the site of positive surgical margin in salvage external beam radiation therapy for biochemical recurrence of prostate cancer after radical prostatectomy. Cancer Med. 2018;7(5):1723\u201330.","journal-title":"Cancer Med"},{"issue":"5","key":"767_CR19","doi-asserted-by":"publisher","first-page":"479","DOI":"10.6004\/jnccn.2019.0023","volume":"17","author":"JL Mohler","year":"2019","unstructured":"Mohler JL, Antonarakis ES, Armstrong AJ, et al. Prostate Cancer, Version 2.2019, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2019;17(5):479\u2013505.","journal-title":"J Natl Compr Cancer Netw"},{"issue":"3","key":"767_CR20","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s11999-011-2106-5","volume":"470","author":"CL Emory","year":"2012","unstructured":"Emory CL, Montgomery CO, Potter BK, et al. Early complications of high-dose-rate brachytherapy in soft tissue sarcoma: a comparison with traditional external-beam radiotherapy. Clin Orthop Relat Res. 2012;470(3):751\u20138.","journal-title":"Clin Orthop Relat Res"},{"key":"767_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ctro.2019.03.006","volume":"18","author":"J Murray","year":"2019","unstructured":"Murray J, Tree AC. Prostate cancer\u2014advantages and disadvantages of MR-guided RT. Clin Transl Radiat Oncol. 2019;18:68\u201373.","journal-title":"Clin Transl Radiat Oncol"},{"issue":"12","key":"767_CR22","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/j.cgh.2012.07.017","volume":"10","author":"L Fuccio","year":"2012","unstructured":"Fuccio L, Guido A, Andreyev HJ. Management of intestinal complications in patients with pelvic radiation disease. Clin Gastroenterol Hepatol. 2012;10(12):1326\u201334.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"767_CR23","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.prro.2019.02.012","volume":"9","author":"T Kashihara","year":"2019","unstructured":"Kashihara T, Murakami N, Iizumi S, et al. Hemorrhage from ascending colon and gluteal muscle associated with Sorafenib and radiation therapy: radiation dose distribution corresponded with colonoscopy findings and computed tomography images. Pract Radiat Oncol. 2019;9(4):214\u20139.","journal-title":"Pract Radiat Oncol"},{"issue":"31","key":"767_CR24","doi-asserted-by":"publisher","first-page":"6972","DOI":"10.3748\/wjg.v22.i31.6972","volume":"22","author":"JP Weiner","year":"2016","unstructured":"Weiner JP, Wong AT, Schwartz D, et al. Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding. World J Gastroenterol. 2016;22(31):6972\u201386.","journal-title":"World J Gastroenterol"},{"key":"767_CR25","doi-asserted-by":"publisher","first-page":"bcr2014206931","DOI":"10.1136\/bcr-2014-206931","volume":"2014","author":"AY Teh","year":"2014","unstructured":"Teh AY, Ko HT, Barr G, et al. Rectal ulcer associated with SpaceOAR hydrogel insertion during prostate brachytherapy. BMJ Case Rep. 2014;2014:bcr2014206931.","journal-title":"BMJ Case Rep."},{"issue":"5","key":"767_CR26","first-page":"789","volume":"29","author":"A Sahin","year":"2019","unstructured":"Sahin A, Kilic M, Dalgic N. A case report of a 4-year-old boy with intradural spinal cord abscess successfully treated with adjuvant hyperbaric oxygen therapy. Turk Neurosurg. 2019;29(5):789\u201392.","journal-title":"Turk Neurosurg"},{"issue":"Suppl 2","key":"767_CR27","first-page":"540","volume":"62","author":"M Kutlay","year":"2008","unstructured":"Kutlay M, Colak A, Yildiz S, et al. Stereotactic aspiration and antibiotic treatment combined with hyperbaric oxygen therapy in the management of bacterial brain abscesses. Neurosurgery. 2008;62(Suppl 2):540\u20136.","journal-title":"Neurosurgery"},{"issue":"8","key":"767_CR28","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1586\/eri.09.76","volume":"7","author":"M Cim\u015fit","year":"2009","unstructured":"Cim\u015fit M, Uzun G, Yildiz S. Hyperbaric oxygen therapy as an anti-infective agent. Expert Rev Anti Infect Ther. 2009;7(8):1015\u201326.","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"7","key":"767_CR29","doi-asserted-by":"publisher","first-page":"e229873","DOI":"10.1136\/bcr-2019-229873","volume":"12","author":"F Ciodaro","year":"2019","unstructured":"Ciodaro F, Gazia F, Galletti B, et al. Hyperbaric oxygen therapy in a case of cervical abscess extending to anterior mediastinum, with isolation of Prevotella corporis. BMJ Case Rep. 2019;12(7):e229873.","journal-title":"BMJ Case Rep"},{"issue":"12","key":"767_CR30","first-page":"641","volume":"172","author":"A Hartmann","year":"1996","unstructured":"Hartmann A, Almeling M, Carl UM. Hyperbaric oxygenation (HBO) in the treatment of radiogenic side effects. Strahlenther Onkol. 1996;172(12):641\u20138.","journal-title":"Strahlenther Onkol"},{"issue":"Suppl 3","key":"767_CR31","first-page":"99","volume":"174","author":"D Peusch-Dreyer","year":"1998","unstructured":"Peusch-Dreyer D, Dreyer KH, M\u00fcller CD, et al. Management of postoperative radiation injury of the urinary bladder by hyperbaric oxygen (HBO). Strahlenther Onkol. 1998;174(Suppl 3):99\u2013100.","journal-title":"Strahlenther Onkol"},{"issue":"6","key":"767_CR32","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1097\/01.ju.0000063640.41307.c9","volume":"169","author":"JM Corman","year":"2003","unstructured":"Corman JM, McClure D, Pritchett R, et al. Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen. J Urol. 2003;169(6):2200\u20132.","journal-title":"J Urol"},{"issue":"6","key":"767_CR33","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s11934-018-0790-3","volume":"19","author":"J Cardinal","year":"2018","unstructured":"Cardinal J, Slade A, McFarland M, et al. Scoping review and meta-analysis of hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis. Curr Urol Rep. 2018;19(6):38.","journal-title":"Curr Urol Rep"},{"issue":"11","key":"767_CR34","first-page":"2407","volume":"77","author":"HL Ashamalla","year":"1996","unstructured":"Ashamalla HL, Thom SR, Goldwein JW. Hyperbaric oxygen therapy for the treatment of radiation-induced sequelae in children. Univ Pa Exp Cancer. 1996;77(11):2407\u201312.","journal-title":"Univ Pa Exp Cancer"},{"issue":"4","key":"767_CR35","first-page":"1948","volume":"11","author":"SL Hsu","year":"2019","unstructured":"Hsu SL, Yin TC, Shao PL, et al. Hyperbaric oxygen facilitates the effect of endothelial progenitor cell therapy on improving outcome of rat critical limb ischemia. Am J Transl Res. 2019;11(4):1948\u201364.","journal-title":"Am J Transl Res"},{"issue":"Suppl 1","key":"767_CR36","doi-asserted-by":"publisher","first-page":"131S","DOI":"10.1097\/PRS.0b013e3181fbe2bf","volume":"127","author":"SR Thom","year":"2011","unstructured":"Thom SR. Hyperbaric oxygen\u2014its mechanisms and efficacy. Plast Reconstr Surg. 2011;127(Suppl 1):131S-141S.","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"767_CR37","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.urology.2004.10.050","volume":"65","author":"KT Chong","year":"2005","unstructured":"Chong KT, Hampson NB, Corman JM. Early hyperbaric oxygen therapy improves outcome for radiation-induced hemorrhagic cystitis. Urology. 2005;65(4):649\u201353.","journal-title":"Urology"},{"key":"767_CR38","first-page":"1","volume":"30","author":"J Feldmeier","year":"2003","unstructured":"Feldmeier J, Carl U, Hartmann K, et al. Hyperbaric oxygen: does it promote growth or recurrence of malignancy? Undersea Hyperb Med. 2003;30:1\u201318.","journal-title":"Undersea Hyperb Med"},{"key":"767_CR39","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1007\/s00268-006-0190-6","volume":"30","author":"J Daruwalla","year":"2006","unstructured":"Daruwalla J, Christophi C. Hyperbaric oxygen therapy for malignancy: a review. World J Surg. 2006;30:2112\u201331.","journal-title":"World J Surg"},{"issue":"4","key":"767_CR40","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s11523-012-0233-x","volume":"7","author":"I Moen","year":"2012","unstructured":"Moen I, Stuhr LE. Hyperbaric oxygen therapy and cancer\u2014a review. Target Oncol. 2012;7(4):233\u201342.","journal-title":"Target Oncol"}],"container-title":["BMC Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12894-020-00767-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12894-020-00767-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12894-020-00767-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T13:07:45Z","timestamp":1607951265000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcurol.biomedcentral.com\/articles\/10.1186\/s12894-020-00767-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["767"],"URL":"https:\/\/doi.org\/10.1186\/s12894-020-00767-3","relation":{},"ISSN":["1471-2490"],"issn-type":[{"value":"1471-2490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"12 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All analyses involving human participants performed in this study were approved by the Institutional Review Board of the National Cancer Center Hospital (approval number, 2017-091) and were in accordance with the ethical standards of the committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Dr. Inaba reports\u00a0personal fees from Boston Scientific Japan,\u00a0and grants from Elekta K.K., outside the submitted work. Dr. Nakayama reports personal fees from AstraZeneca, outside the submitted work. Dr. Igaki reports personal fees from Itochu, personal fees from ViewRay Inc., grants from HekaBio, outside the submitted work. Dr. Itami reports grants and non-financial support from KeyJ, personal fees from Alpha Tau, personal fees from ItoChu, outside the submitted work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"196"}}