{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T17:37:38Z","timestamp":1776533858356,"version":"3.51.2"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2019JJ40506"],"award-info":[{"award-number":["2019JJ40506"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Urol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Urothelial bladder cancer (BC) is one of the most prevalent malignancies with high mortality and high recurrence rate. Angiogenesis, tumor growth and metastasis of multiple cancers are partly modulated by CC chemokines. However, we know little about the function of distinct CC chemokines in BC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>ONCOMINE, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan\u2013Meier plotter, cBioPortal, GeneMANIA, and TIMER were used for analyzing differential expression, prognostic value, protein\u2013protein interaction, genetic alteration and immune cell infiltration of CC chemokines in BC patients based on bioinformatics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results showed that transcriptional levels of CCL2\/3\/4\/5\/14\/19\/21\/23 in BC patients were significantly reduced. A significant relation was observed between the expression of CCL2\/11\/14\/18\/19\/21\/23\/24\/26 and the pathological stage of BC patients. BC patients with high expression levels of CCL1, CCL2, CCL3, CCL4, CCL5, CCL8, CCL13, CCL15, CCL17, CCL18, CCL19, CCL22, CCL25, CCL27 were associated with a significantly better prognosis. Moreover, we found that differentially expressed CC chemokines are primarily correlated with cytokine activity, chemokines receptor binding, chemotaxis, immune cell migration. Further, there were significant correlations among the expression of CC chemokines and the infiltration of several types of immune cells (B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study is an analysis to the potential role of CC chemokines in the therapeutic targets and prognostic biomarkers of BC, which gives a novel insight into the relationship between CC chemokines and BC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12894-021-00938-w","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T13:03:57Z","timestamp":1639141437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Identification of prognostic and therapeutic value of CC chemokines in Urothelial bladder cancer: evidence from comprehensive bioinformatic analysis"],"prefix":"10.1186","volume":"21","author":[{"given":"Yuxin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoBo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"938_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394\u2013424.","journal-title":"CA Cancer J Clin"},{"key":"938_CR2","first-page":"57","volume":"86","author":"B Helpap","year":"2002","unstructured":"Helpap B. New WHO classification of urothelial carcinoma of the urinary bladder. Verh Dtsch Ges Pathol. 2002;86:57\u201366.","journal-title":"Verh Dtsch Ges Pathol"},{"key":"938_CR3","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1001\/jama.2018.4657","volume":"319","author":"EM Messing","year":"2018","unstructured":"Messing EM, Tangen CM, Lerner SP, Sahasrabudhe DM, Koppie TM, Wood DP, et al. Effect of intravesical instillation of gemcitabine vs saline immediately following resection of suspected low-grade non-muscle-invasive bladder cancer on tumor recurrence: SWOG S0337 randomized clinical trial. JAMA. 2018;319:1880\u20138.","journal-title":"JAMA"},{"key":"938_CR4","unstructured":"Witjes JA, Bruins M, Cathomas R, Comp\u00e9rat E, Cowan NC, Gakis G, et al. EAU guidelines on muscle-invasive and metastatic bladder cancer 2020. In: European Association of Urology Guidelines. 2020 Edition. Arnhem, The Netherlands: European Association of Urology Guidelines Office; 2020. http:\/\/uroweb.org\/guideline\/bladder-cancer-muscle-invasive-and-metastatic\/."},{"key":"938_CR5","unstructured":"Babjuk M, Burger M, Comp\u00e9rat E, Gontero P, Mostafid AH, Palou J, et al. EAU guidelines on non-muscle-invasive bladder cancer (TaT1 and CIS) 2020. In: European Association of Urology Guidelines. 2020 Edition. Arnhem, The Netherlands: European Association of Urology Guidelines Office; 2020. http:\/\/uroweb.org\/guideline\/non-muscle-invasive-bladder-cancer\/."},{"key":"938_CR6","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1038\/551S34a","volume":"551","author":"C Berdik","year":"2017","unstructured":"Berdik C. Unlocking bladder cancer. Nature. 2017;551:S34\u20135.","journal-title":"Nature"},{"key":"938_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.canep.2013.02.002","volume":"37","author":"F Abdollah","year":"2013","unstructured":"Abdollah F, Gandaglia G, Thuret R, Schmitges J, Tian Z, Jeldres C, et al. Incidence, survival and mortality rates of stage-specific bladder cancer in United States: a trend analysis. Cancer Epidemiol. 2013;37:219\u201325.","journal-title":"Cancer Epidemiol"},{"key":"938_CR8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ucl.2013.01.004","volume":"40","author":"AC James","year":"2013","unstructured":"James AC, Gore JL. The costs of non-muscle invasive bladder cancer. Urol Clin North Am. 2013;40:261\u20139.","journal-title":"Urol Clin North Am"},{"key":"938_CR9","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.eururo.2018.09.047","volume":"75","author":"JE Gschwend","year":"2019","unstructured":"Gschwend JE, Heck MM, Lehmann J, R\u00fcbben H, Albers P, Wolff JM, et al. Extended versus limited lymph node dissection in bladder cancer patients undergoing radical cystectomy: survival results from a prospective. Randomized Trial Eur Urol. 2019;75:604\u201311.","journal-title":"Randomized Trial Eur Urol"},{"key":"938_CR10","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nri.2017.49","volume":"17","author":"N Nagarsheth","year":"2017","unstructured":"Nagarsheth N, Wicha MS, Zou W. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nat Rev Immunol. 2017;17:559\u201372.","journal-title":"Nat Rev Immunol"},{"key":"938_CR11","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature10138","volume":"475","author":"B-Z Qian","year":"2011","unstructured":"Qian B-Z, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011;475:222\u20135.","journal-title":"Nature"},{"key":"938_CR12","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.ccr.2011.02.006","volume":"19","author":"J Chen","year":"2011","unstructured":"Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell. 2011;19:541\u201355.","journal-title":"Cancer Cell"},{"key":"938_CR13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.bbrc.2014.01.172","volume":"446","author":"J Zheng","year":"2014","unstructured":"Zheng J, Zhu X, Zhang J. CXCL5 knockdown expression inhibits human bladder cancer T24 cells proliferation and migration. Biochem Biophys Res Commun. 2014;446:18\u201324.","journal-title":"Biochem Biophys Res Commun"},{"key":"938_CR14","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.1172\/JCI125336","volume":"129","author":"J Park","year":"2019","unstructured":"Park J, Zhang X, Lee SK, Song N-Y, Son SH, Kim KR, et al. CCL28-induced RAR\u03b2 expression inhibits oral squamous cell carcinoma bone invasion. J Clin Invest. 2019;129:5381\u201399.","journal-title":"J Clin Invest"},{"key":"938_CR15","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nbt.4086","volume":"36","author":"K Adachi","year":"2018","unstructured":"Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K. IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol. 2018;36:346\u201351.","journal-title":"Nat Biotechnol"},{"key":"938_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3390\/cells10010159","volume":"10","author":"H Taubert","year":"2021","unstructured":"Taubert H, Eckstein M, Epple E, Jung R, Weigelt K, Lieb V, et al. Immune cell-associated protein expression helps to predict survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and optional adjuvant chemotherapy. Cells. 2021;10:159.","journal-title":"Cells"},{"key":"938_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1476-5586(04)80047-2","volume":"6","author":"DR Rhodes","year":"2004","unstructured":"Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia. 2004;6:1\u20136.","journal-title":"Neoplasia"},{"key":"938_CR18","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98-102.","journal-title":"Nucleic Acids Res"},{"key":"938_CR19","doi-asserted-by":"publisher","first-page":"6047","DOI":"10.1038\/s41598-021-84787-5","volume":"11","author":"\u00c1 Nagy","year":"2021","unstructured":"Nagy \u00c1, Munk\u00e1csy G, Gy\u0151rffy B. Pancancer survival analysis of cancer hallmark genes. Sci Rep. 2021;11:6047.","journal-title":"Sci Rep"},{"key":"938_CR20","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6:pl1.","journal-title":"Sci Signal."},{"key":"938_CR21","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607\u201313.","journal-title":"Nucleic Acids Res"},{"key":"938_CR22","doi-asserted-by":"publisher","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"D Warde-Farley","year":"2010","unstructured":"Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, et al. The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010;38:W214\u201320.","journal-title":"Nucleic Acids Res."},{"key":"938_CR23","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","volume":"77","author":"T Li","year":"2017","unstructured":"Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017;77:e108\u201310.","journal-title":"Cancer Res"},{"key":"938_CR24","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u201349.","journal-title":"CA Cancer J Clin"},{"key":"938_CR25","doi-asserted-by":"publisher","first-page":"104ra100","DOI":"10.1126\/scitranslmed.3002949","volume":"3","author":"I Kryczek","year":"2011","unstructured":"Kryczek I, Zhao E, Liu Y, Wang Y, Vatan L, Szeliga W, et al. Human TH17 cells are long-lived effector memory cells. Sci Transl Med. 2011;3:104ra100.","journal-title":"Sci Transl Med."},{"key":"938_CR26","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1084\/jem.20031462","volume":"199","author":"LS Metelitsa","year":"2004","unstructured":"Metelitsa LS, Wu H-W, Wang H, Yang Y, Warsi Z, Asgharzadeh S, et al. Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2. J Exp Med. 2004;199:1213\u201321.","journal-title":"J Exp Med"},{"key":"938_CR27","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/nm1093","volume":"10","author":"TJ Curiel","year":"2004","unstructured":"Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10:942\u20139.","journal-title":"Nat Med"},{"key":"938_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ccr.2012.05.023","volume":"22","author":"MJ Wolf","year":"2012","unstructured":"Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell. 2012;22:91\u2013105.","journal-title":"Cancer Cell"},{"key":"938_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/cdd.2013.73","volume":"21","author":"AQ Sukkurwala","year":"2014","unstructured":"Sukkurwala AQ, Martins I, Wang Y, Schlemmer F, Ruckenstuhl C, Durchschlag M, et al. Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8. Cell Death Differ. 2014;21:59\u201368.","journal-title":"Cell Death Differ"},{"key":"938_CR30","doi-asserted-by":"crossref","first-page":"101042831769838","DOI":"10.1177\/1010428317698383","volume":"39","author":"W Wang","year":"2017","unstructured":"Wang W, Shen F, Wang C, Lu W, Wei J, Shang A, et al. MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression. Tumour Biol. 2017;39:1010428317698383.","journal-title":"Tumour Biol"},{"key":"938_CR31","doi-asserted-by":"publisher","first-page":"865684","DOI":"10.1155\/2011\/865684","volume":"2011","author":"SM Tham","year":"2011","unstructured":"Tham SM, Ng KH, Pook SH, Esuvaranathan K, Mahendran R. Tumor and microenvironment modification during progression of murine orthotopic bladder cancer. Clin Dev Immunol. 2011;2011:865684.","journal-title":"Clin Dev Immunol."},{"key":"938_CR32","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3390\/cancers12051253","volume":"12","author":"M Eckstein","year":"2020","unstructured":"Eckstein M, Epple E, Jung R, Weigelt K, Lieb V, Sikic D, et al. CCL2 expression in tumor cells and tumor-infiltrating immune cells shows divergent prognostic potential for bladder cancer patients depending on lymph node stage. Cancers Basel. 2020;12:1253.","journal-title":"Cancers Basel"},{"key":"938_CR33","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.molimm.2019.02.014","volume":"109","author":"X-Y Mu","year":"2019","unstructured":"Mu X-Y, Wang R-J, Yao Z-X, Zheng Z, Jiang J-T, Tan M-Y, et al. RS 504393 inhibits M-MDSCs recruiting in immune microenvironment of bladder cancer after gemcitabine treatment. Mol Immunol. 2019;109:140\u20138.","journal-title":"Mol Immunol"},{"key":"938_CR34","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.cyto.2012.04.017","volume":"59","author":"H-Y Chiu","year":"2012","unstructured":"Chiu H-Y, Sun K-H, Chen S-Y, Wang H-H, Lee M-Y, Tsou Y-C, et al. Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells. Cytokine. 2012;59:423\u201332.","journal-title":"Cytokine"},{"key":"938_CR35","doi-asserted-by":"publisher","first-page":"3826","DOI":"10.1038\/s41467-018-06152-x","volume":"9","author":"C Chen","year":"2018","unstructured":"Chen C, He W, Huang J, Wang B, Li H, Cai Q, et al. LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment. Nat Commun. 2018;9:3826.","journal-title":"Nat Commun"},{"key":"938_CR36","doi-asserted-by":"publisher","first-page":"110044","DOI":"10.1016\/j.cellsig.2021.110044","volume":"85","author":"W Ma","year":"2021","unstructured":"Ma W, Ou T, Cui X, Wu K, Li H, Li Y, et al. HSP47 contributes to angiogenesis by induction of CCL2 in bladder cancer. Cell Signal. 2021;85:110044.","journal-title":"Cell Signal"},{"key":"938_CR37","doi-asserted-by":"publisher","first-page":"7842","DOI":"10.18632\/oncotarget.5467","volume":"7","author":"Q Rao","year":"2016","unstructured":"Rao Q, Chen Y, Yeh C-R, Ding J, Li L, Chang C, et al. Recruited mast cells in the tumor microenvironment enhance bladder cancer metastasis via modulation of ER\u03b2\/CCL2\/CCR2 EMT\/MMP9 signals. Oncotarget. 2016;7:7842\u201355.","journal-title":"Oncotarget"},{"key":"938_CR38","first-page":"1146","volume":"5","author":"C-R Yeh","year":"2015","unstructured":"Yeh C-R, Hsu I, Song W, Chang H, Miyamoto H, Xiao G-Q, et al. Fibroblast ER\u03b1 promotes bladder cancer invasion via increasing the CCL1 and IL-6 signals in the tumor microenvironment. Am J Cancer Res. 2015;5:1146\u201357.","journal-title":"Am J Cancer Res"},{"key":"938_CR39","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1158\/1078-0432.CCR-12-2091","volume":"19","author":"E Eruslanov","year":"2013","unstructured":"Eruslanov E, Stoffs T, Kim W-J, Daurkin I, Gilbert SM, Su L-M, et al. Expansion of CCR8(+) inflammatory myeloid cells in cancer patients with urothelial and renal carcinomas. Clin Cancer Res. 2013;19:1670\u201380.","journal-title":"Clin Cancer Res"},{"key":"938_CR40","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3892\/mmr.2015.4503","volume":"13","author":"Q Cao","year":"2016","unstructured":"Cao Q, Wang N, Qi J, Gu Z, Shen H. Long non-coding RNA-GAS5 acts as a tumor suppressor in bladder transitional cell carcinoma via regulation of chemokine (C-C motif) ligand 1 expression. Mol Med Rep. 2016;13:27\u201334.","journal-title":"Mol Med Rep"},{"key":"938_CR41","doi-asserted-by":"publisher","first-page":"e37797","DOI":"10.1371\/journal.pone.0037797","volume":"7","author":"V Urquidi","year":"2012","unstructured":"Urquidi V, Kim J, Chang M, Dai Y, Rosser CJ, Goodison S. CCL18 in a multiplex urine-based assay for the detection of bladder cancer. PLOS ONE. 2012;7:e37797.","journal-title":"PLOS ONE."},{"key":"938_CR42","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1471-2490-13-42","volume":"13","author":"M Miyake","year":"2013","unstructured":"Miyake M, Ross S, Lawton A, Chang M, Dai Y, Mengual L, et al. Investigation of CCL18 and A1AT as potential urinary biomarkers for bladder cancer detection. BMC Urol. 2013;13:42.","journal-title":"BMC Urol"},{"key":"938_CR43","first-page":"1678","volume":"19","author":"X Liu","year":"2019","unstructured":"Liu X, Xu X, Deng W, Huang M, Wu Y, Zhou Z, et al. CCL18 enhances migration, invasion and EMT by binding CCR8 in bladder cancer cells. Mol Med Rep. 2019;19:1678\u201386.","journal-title":"Mol Med Rep"},{"key":"938_CR44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3892\/ijo.2017.4003","volume":"51","author":"Y Xiong","year":"2017","unstructured":"Xiong Y, Huang F, Li X, Chen Z, Feng D, Jiang H, et al. CCL21\/CCR7 interaction promotes cellular migration and invasion via modulation of the MEK\/ERK1\/2 signaling pathway and correlates with lymphatic metastatic spread and poor prognosis in urinary bladder cancer. Int J Oncol. 2017;51:75\u201390.","journal-title":"Int J Oncol"}],"container-title":["BMC Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12894-021-00938-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12894-021-00938-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12894-021-00938-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:00:03Z","timestamp":1722927603000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcurol.biomedcentral.com\/articles\/10.1186\/s12894-021-00938-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,10]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["938"],"URL":"https:\/\/doi.org\/10.1186\/s12894-021-00938-w","relation":{},"ISSN":["1471-2490"],"issn-type":[{"value":"1471-2490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,10]]},"assertion":[{"value":"31 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"173"}}