{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:14:56Z","timestamp":1775499296748,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Private Universit\u00e4t Witten\/Herdecke gGmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Urol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ichthyosis is a rare skin disorder, in which the shedding of squamous cells is altered. Intravesical ichthyosis is an extremely rare condition. There is evidence for an association with intravesical condylomata accuminata, caused by urogenital infections of the human papilloma virus. These lesions are generally benign but known to be of a carcinogenic potential and therefore should be treated immediately and followed-up closely.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present the case of a 39-year-old woman who presented with recurrent urinary tract infections. During cystoscopy diffuse black pigmented flat bladder tumours were visualized. After transurethral resection the pathological report diagnosed an ichthyosis vesicae.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We recommend a complete resection with frequent clinical and cystoscopic follow-up. Furthermore, testing for the human papilloma virus should be performed and a vaccination should be offered to the patient. As ichthyosis vesicae is a rare phenomenon, there is an evident lack of clinical data regarding therapy, prognosis and follow-up. With our report, we want to emphasize the need for further research.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12894-021-00939-9","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T11:14:19Z","timestamp":1639739659000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravesical ichthyosis: a rare case report"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-6167","authenticated-orcid":false,"given":"T.","family":"Hermans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"grosse Siemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. C.","family":"von Rundstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"issue":"1","key":"939_CR1","first-page":"5","volume":"25","author":"AL Limmer","year":"2020","unstructured":"Limmer AL, Nwannunu CE, Tyring SK, et al. Management of ichthyosis: a brief review. Skin Therapy Lett. 2020;25(1):5\u20137.","journal-title":"Skin Therapy Lett"},{"issue":"4","key":"939_CR2","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.jaad.2006.04.047","volume":"55","author":"N Patel","year":"2006","unstructured":"Patel N, Spencer LA, Zirwas MJ, et al. Acquired ichthyosis. J Am Acad Dermatol. 2006;55(4):647\u201356.","journal-title":"J Am Acad Dermatol"},{"key":"939_CR3","first-page":"1","volume":"15","author":"J Heinzmann","year":"2020","unstructured":"Heinzmann J, Schneider A, Riener MO. Development of a squamous cell carcinoma of the urinary bladder after intravesical condylomas. Akt Urol. 2020;15:1-96e3.","journal-title":"Akt Urol"},{"issue":"4","key":"939_CR4","doi-asserted-by":"publisher","first-page":"928.e13","DOI":"10.1016\/j.urology.2008.05.039","volume":"73","author":"S Sanborn","year":"2009","unstructured":"Sanborn S, MacLennan G, Ponsky L, et al. High-grade transitional cell carcinoma and melanosis of urinary bladder: case report and review of the literature. Urology. 2009;73(4):928.e13-5.","journal-title":"Urology"},{"issue":"5","key":"939_CR5","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/S0090-4295(90)80298-2","volume":"36","author":"A Batta","year":"1990","unstructured":"Batta A, Engen D, Winkelmann R, et al. Intravesical condyloma acuminatum with progression to verrucous carcinoma. Urology. 1990;36(5):457\u201364.","journal-title":"Urology"},{"issue":"11","key":"939_CR6","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1097\/PAS.0000000000001339","volume":"43","author":"I Samarska","year":"2019","unstructured":"Samarska I, Epstein J. Condyloma acuminatum of urinary bladder: relation to squamous cell carcinoma. Am J Surg Pathol. 2019;43(11):1547\u201353.","journal-title":"Am J Surg Pathol"},{"key":"939_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.eucr.2016.04.016","volume":"7","author":"A Khambati","year":"2016","unstructured":"Khambati A, Bhanji Y, Kundu SD. Progression of intravesical condyloma acuminata to locally advanced poorly differentiated squamous cell carcinoma. Urol Case Rep. 2016;7:61\u20133. https:\/\/doi.org\/10.1016\/j.eucr.2016.04.016.","journal-title":"Urol Case Rep"},{"issue":"3","key":"939_CR8","doi-asserted-by":"publisher","first-page":"198","DOI":"10.20344\/amp.12259","volume":"33","author":"R Medeiros","year":"2020","unstructured":"Medeiros R, Vaz S, Figueiredo-Dias M, et al. Prevention of human papillomavirus infection. Beyond cervical cancer: a brief review. Acta Med Port. 2020;33(3):198\u2013201.","journal-title":"Acta Med Port"},{"key":"939_CR9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1746-1596-1-8","volume":"1","author":"O Fadare","year":"2006","unstructured":"Fadare O. Dysplastic Ichthyosis uteri-like changes of the entire endometrium associated with a squamous cell carcinoma of the uterine cervix. Diagn Pathol. 2006;1:8.","journal-title":"Diagn Pathol"},{"key":"939_CR10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1746-1596-3-4","volume":"3","author":"K Murhekar","year":"2008","unstructured":"Murhekar K, Majhi U, Rajkumar T, et al. Does \u201cichthyosis uteri\u201d have malignant potential? A case report of squamous cell carcinoma of endometrium associated with extensive ichthyosis uteri. Diagn Pathol. 2008;3:4.","journal-title":"Diagn Pathol"},{"issue":"4","key":"939_CR11","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1055\/s-2008-1035908","volume":"46","author":"V Heckeroth","year":"1986","unstructured":"Heckeroth V, Ziegler HK. Zur Kenntnis der Ichthyosis uteri. Fallbericht eines seltenen Krankheitsbildes [Ichthyosis uteri. Case report on a rare clinical entity]. Geburtshilfe Frauenheilkd. 1986;46(4):248\u20139 ((German)).","journal-title":"Geburtshilfe Frauenheilkd"}],"container-title":["BMC Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12894-021-00939-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12894-021-00939-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12894-021-00939-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T11:14:31Z","timestamp":1639739671000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcurol.biomedcentral.com\/articles\/10.1186\/s12894-021-00939-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["939"],"URL":"https:\/\/doi.org\/10.1186\/s12894-021-00939-9","relation":{},"ISSN":["1471-2490"],"issn-type":[{"value":"1471-2490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"11 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was given by patient, full anonymization","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was given by patient","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"177"}}