{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:34:16Z","timestamp":1787020456203,"version":"build-2736575974"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Urol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bladder outlet obstruction (BOO) was caused by a series of histological and biochemical changes in the bladder wall, through the inflammation process in the bladder wall, hypertrophy and fibrosis. ADSC has an important role in bladder regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and materials<\/jats:title>\n                    <jats:p>This study was an experimental randomized study using male Wistar rats which were monitored at 2 and 4\u00a0weeks to determine the effect of ADSC therapy on TGF-\u03b21 type I collagen, and degree of fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Rats were divided into 5 groups. In the week 2 BOO group, 1 sample included in the category of moderate fibrosis, 1 sample that was given ADSC with mild fibrosis category, 3 samples included in severe fibrosis category, 3 samples that were given ADSC included in the category of moderate fibrosis. The concentration of TGF-\u03b21 in the hADSC therapy group was significantly lower than the control group at the 2nd and 4th week of monitoring (p2\u2009=\u20090.048, p4\u2009=\u20090.048), and also with more type I collagen on 2nd and the 4th week (p2\u2009=\u20090.048, p4\u2009=\u20090.048).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ADSC therapy can reduce the concentration of TGF-\u03b21, type I collagen, and degree of fibrosis in the male Wistar BOO model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12894-022-01019-2","type":"journal-article","created":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T09:02:37Z","timestamp":1650790957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of human adipose-derived stem cells (hADSC) on TGF-\u03b21, type I collagen, and fibrosis degree in bladder obstruction model of Wistar rats"],"prefix":"10.1186","volume":"22","author":[{"given":"Safendra","family":"Siregar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochamad Sri","family":"Herlambang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Reza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhmad","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dicky","family":"Stefanus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,24]]},"reference":[{"key":"1019_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12894-017-0312-5","volume":"18","author":"F Fusco","year":"2018","unstructured":"Fusco F, Creta M, De Nunzio C, Iacovelli V, Mangiapia F, Marzi VL, et al. 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The use of animals in this study was approved by Ethics Committee of Universitas Padjadjaran. The study was carried out in compliance with the ARRIVE guidelines. All methods were carried out in accordance\u00a0with relevant guidelines and regulations. All experimental protocols were approved by Dr. Soetomo General Hospital Surabaya's Tissue and Cell Bank under the approval of ethics committee Universitas Padjadjaran. Informed consent was obtained from all subjects and\/or their legal guardian(s) under the ethics committee of Universitas Padjadjaran.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}