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Additionally, Metabolic Syndrome (MetS), characterized by central obesity, high blood sugar, lipid metabolism disorders, and hypertension, is increasingly recognized as a proinflammatory condition linked to prostate inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data from 108 subjects who underwent transurethral resection of the prostate or bipolar plasmakinetic enucleation of the prostate were prospectively collected between June 2021 and August 2022. Patients were divided in two groups according to whether or not they had a diagnosis of MetS. Specimens were stained with Masson trichrome and the periurethral prostatic fibrosis extent was evaluated using quantitative morphometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-three patients (39.8%) were diagnosed with MetS. Patients with MetS showed a significantly greater\u00a0extent of prostatic fibrosis than the others (68.1\u2009\u00b1\u200917.1% vs. 42.5\u2009\u00b1\u200918.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and there was a positive correlation between the number of positive MetS parameters and the extent of prostatic fibrosis (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.4436,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate regression analysis revealed that central obesity (B\u2009=\u20092.941, 95% confidence interval, 1.700\u20133.283), elevated fasting glucose (B\u2009=\u20091.036, 95% confidence interval, 0.293\u20131.780), reduced HDL cholesterol (B\u2009=\u20090.910, 95% confidence interval, 0.183\u20131.636) and elevated triglycerides (B\u2009=\u20091.666, 95% confidence interval, 0.824\u20132.508) were positively correlated to prostatic fibrosis. Elevated blood pressure, however, was unrelated to prostatic fibrosis (B\u2009=\u20090.009, 95% confidence interval, -0.664\u20130.683).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present findings suggest that prostatic fibrosis is positively correlated with MetS and its components including central obesity, elevated fasting glucose, reduced high density lipoprotein cholesterol and elevated triglycerides.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12894-024-01413-y","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T11:03:03Z","timestamp":1707735783000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Correlation between metabolic syndrome and periurethral prostatic fibrosis: results of a prospective study"],"prefix":"10.1186","volume":"24","author":[{"given":"Jingwen","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyue","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"1413_CR1","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1097\/JU.0000000000002450","volume":"207","author":"J \u00c5kerla","year":"2022","unstructured":"\u00c5kerla J, Pesonen JS, P\u00f6yh\u00f6nen A, et al. 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