{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:34:45Z","timestamp":1784770485101,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Biotechnol"],"DOI":"10.1186\/s12896-024-00910-0","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T20:42:55Z","timestamp":1731530575000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of hsa_circ_0136256 as a biomarker for fibrosis in systemic sclerosis"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaolin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingguo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"910_CR1","doi-asserted-by":"crossref","unstructured":"Shima Y. Cytokines involved in the pathogenesis of SSc and problems in the development of anti-cytokine therapy. Cells. 2021;10(5):1104.","DOI":"10.3390\/cells10051104"},{"key":"910_CR2","doi-asserted-by":"publisher","first-page":"109331","DOI":"10.1016\/j.cellsig.2019.05.016","volume":"62","author":"X Sun","year":"2019","unstructured":"Sun X, Wei W, Ren J, Liang Y, Wang M, Gui Y, Xue X, Li J, Dai C. Inhibition of 4E-BP1 phosphorylation promotes tubular cell escaping from G2\/M arrest and ameliorates kidney fibrosis. Cell Signal. 2019;62:109331.","journal-title":"Cell Signal"},{"issue":"1","key":"910_CR3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41467-018-07858-8","volume":"10","author":"H Woodcock","year":"2019","unstructured":"Woodcock H, Eley J, Guillotin D, Plat\u00e9 M, Nanthakumar C, Martufi M, Peace S, Joberty G, Poeckel D, Good R, et al. The mTORC1\/4E-BP1 axis represents a critical signaling node during fibrogenesis. Nat Commun. 2019;10(1):6.","journal-title":"Nat Commun"},{"issue":"4","key":"910_CR4","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1042\/EBC20200032","volume":"65","author":"H Yan","year":"2021","unstructured":"Yan H, Bu P. Non-coding RNA in cancer. Essays Biochem. 2021;65(4):625\u201339.","journal-title":"Essays Biochem"},{"issue":"12","key":"910_CR5","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","volume":"185","author":"C Liu","year":"2022","unstructured":"Liu C, Chen L. Circular RNAs: Characterization, cellular roles, and applications. Cell. 2022;185(12):2016\u201334.","journal-title":"Cell"},{"issue":"8","key":"910_CR6","first-page":"995","volume":"15","author":"W Ng","year":"2018","unstructured":"Ng W, Mohd Mohidin T, Shukla K. Functional role of circular RNAs in cancer development and progression. RNA Biol. 2018;15(8):995\u20131005.","journal-title":"RNA Biol"},{"issue":"2","key":"910_CR7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/exd.12900","volume":"25","author":"Z Wang","year":"2016","unstructured":"Wang Z, Jinnin M, Nakamura K, Harada M, Kudo H, Nakayama W, Inoue K, Nakashima T, Honda N, Fukushima S, et al. Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization. Exp Dermatol. 2016;25(2):131\u20136.","journal-title":"Exp Dermatol"},{"key":"910_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.947975","volume":"9","author":"X Bi","year":"2022","unstructured":"Bi X, Song Y, Yang C, Song Y, Zhao S, Qiao S, Zhang J. Sex differences in atrial remodeling and its relationship with myocardial fibrosis in hypertrophic obstructive cardiomyopathy. Frontiers in cardiovascular medicine. 2022;9: 947975.","journal-title":"Frontiers in cardiovascular medicine"},{"issue":"3","key":"910_CR9","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/s41419-019-1430-7","volume":"10","author":"J Zhang","year":"2019","unstructured":"Zhang J, Lu J, Xie H, Wang D, Ni H, Zhu Y, Ren L, Meng X, Wang R. circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA. Cell Death Dis. 2019;10(3):182.","journal-title":"Cell Death Dis"},{"issue":"1","key":"910_CR10","doi-asserted-by":"publisher","first-page":"14272","DOI":"10.1038\/s41598-017-14612-5","volume":"7","author":"H Hsu","year":"2017","unstructured":"Hsu H, Liu C, Lin J, Hsu T, Hsu J, Su K, Hung S. Involvement of ER stress, PI3K\/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis. Sci Rep. 2017;7(1):14272.","journal-title":"Sci Rep"},{"key":"910_CR11","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1038\/ncomms3869","volume":"4","author":"J von Maltzahn","year":"2013","unstructured":"von Maltzahn J, Zinoviev R, Chang N, Bentzinger C, Rudnicki M. A truncated Wnt7a retains full biological activity in skeletal muscle. Nat Commun. 2013;4:2869.","journal-title":"Nat Commun"},{"issue":"1","key":"910_CR12","doi-asserted-by":"publisher","first-page":"9500","DOI":"10.1038\/s41598-019-45932-3","volume":"9","author":"W Dai","year":"2019","unstructured":"Dai W, Liu Y, Zhang Y, Sun Y, Sun C, Zhang Y, Lv X. Expression of neuropeptide Y is increased in an activated human HSC cell line. Sci Rep. 2019;9(1):9500.","journal-title":"Sci Rep"},{"issue":"3","key":"910_CR13","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e18","volume":"18","author":"V Rakhmanova","year":"2018","unstructured":"Rakhmanova V, Jin M, Shin J. Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485. Immune network. 2018;18(3): e18.","journal-title":"Immune network"},{"issue":"1","key":"910_CR14","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12931-020-01369-1","volume":"21","author":"S R\u00f8nnow","year":"2020","unstructured":"R\u00f8nnow S, Dabbagh R, Genovese F, Nanthakumar C, Barrett V, Good R, Brockbank S, Cruwys S, Jessen H, Sorensen G, et al. Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis. Respir Res. 2020;21(1):108.","journal-title":"Respir Res"},{"issue":"8","key":"910_CR15","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1136\/annrheumdis-2016-210911","volume":"76","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Liang R, Chen C, Mallano T, Dees C, Distler A, Reich A, Bergmann C, Ramming A, Gelse K, et al. JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment. Ann Rheum Dis. 2017;76(8):1467\u201375.","journal-title":"Ann Rheum Dis"},{"key":"910_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12915-016-0281-2","volume":"14","author":"M Loscertales","year":"2016","unstructured":"Loscertales M, Nicolaou F, Jeanne M, Longoni M, Gould D, Sun Y, Maalouf F, Nagy N, Donahoe P. Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation. BMC Biol. 2016;14:59.","journal-title":"BMC Biol"},{"key":"910_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbplus.2019.04.002","volume":"1","author":"J Merl-Pham","year":"2019","unstructured":"Merl-Pham J, Basak T, Kn\u00fcppel L, Ramanujam D, Athanason M, Behr J, Engelhardt S, Eickelberg O, Hauck S, Vanacore R, et al. in vitroQuantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an model of lung fibrosis. Matrix biology plus. 2019;1: 100005.","journal-title":"Matrix biology plus"},{"key":"910_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2020.08.070","volume":"20","author":"J Stefano","year":"2021","unstructured":"Stefano J, Guedes L, de Souza A, Vanni D, Alves V, Carrilho F, Largura A, Arrese M, Oliveira C. Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease. Ann Hepatol. 2021;20:100253.","journal-title":"Ann Hepatol"},{"issue":"6","key":"910_CR19","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.mayocp.2018.04.009","volume":"93","author":"T Dempsey","year":"2018","unstructured":"Dempsey T, Scanlon P. Pulmonary Function Tests for the Generalist: A Brief Review. Mayo Clin Proc. 2018;93(6):763\u201371.","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"910_CR20","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.ccm.2019.02.011","volume":"40","author":"Y Molgat-Seon","year":"2019","unstructured":"Molgat-Seon Y, Schaeffer M, Ryerson C, Guenette J. Exercise Pathophysiology in Interstitial Lung Disease. Clin Chest Med. 2019;40(2):405\u201320.","journal-title":"Clin Chest Med"},{"key":"910_CR21","doi-asserted-by":"publisher","first-page":"7763","DOI":"10.12659\/MSM.916585","volume":"25","author":"H Lv","year":"2019","unstructured":"Lv H, Liu J, Pan Q, Cai R, Zhang J. Clinical Retrospective Analysis of Interstitial Lung Disease Patients Associated with Pulmonary Hypertension. Medical science monitor\u202f: international medical journal of experimental and clinical research. 2019;25:7763\u20139.","journal-title":"Medical science monitor : international medical journal of experimental and clinical research"},{"issue":"18","key":"910_CR22","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.clinbiochem.2014.08.022","volume":"47","author":"Z Hu","year":"2014","unstructured":"Hu Z, Sun Y, Guo J, Huang Y, Qin B, Gao Q, Qin Q, Deng A, Zhong R. Red blood cell distribution width and neutrophil\/lymphocyte ratio are positively correlated with disease activity in primary Sj\u00f6gren\u2019s syndrome. Clin Biochem. 2014;47(18):287\u201390.","journal-title":"Clin Biochem"},{"issue":"1","key":"910_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10067-017-3871-7","volume":"37","author":"Y He","year":"2018","unstructured":"He Y, Liu C, Zeng Z, Ye W, Lin J, Ou Q. Red blood cell distribution width: a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis. Clin Rheumatol. 2018;37(1):161\u20137.","journal-title":"Clin Rheumatol"},{"issue":"1","key":"910_CR24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s10238-020-00657-w","volume":"21","author":"Y Huang","year":"2021","unstructured":"Huang Y, Chen L, Zhu B, Han H, Hou Y, Wang W. Evaluation of systemic lupus erythematosus disease activity using anti-\u03b1-enolase antibody and RDW. Clin Exp Med. 2021;21(1):73\u20138.","journal-title":"Clin Exp Med"},{"key":"910_CR25","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.rmed.2019.03.003","volume":"150","author":"LA Petrauskas","year":"2019","unstructured":"Petrauskas LA, Saketkoo LA, Kazecki T, Saito S, Jaligam V, deBoisblanc BP, Lammi MR. Use of red cell distribution width in a population at high risk for pulmonary hypertension. Respir Med. 2019;150:131\u20135.","journal-title":"Respir Med"},{"key":"910_CR26","doi-asserted-by":"crossref","unstructured":"Ebata S, Yoshizaki A, Fukasawa T, Yoshizaki-Ogawa A, Asano Y, Kashiwabara K, Oba K, Sato S. Increased red blood cell distribution width in the first year after diagnosis predicts worsening of systemic sclerosis-associated interstitial lung disease at 5 years: A pilot study. Diagnostics (Basel). 2021;11(12):2274.","DOI":"10.3390\/diagnostics11122274"},{"issue":"5","key":"910_CR27","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.semarthrit.2016.10.004","volume":"46","author":"M Merashli","year":"2017","unstructured":"Merashli M, Alves J, Ames P. Clinical relevance of antiphospholipid antibodies in systemic sclerosis: A systematic review and meta-analysis. Semin Arthritis Rheum. 2017;46(5):615\u201324.","journal-title":"Semin Arthritis Rheum"},{"issue":"12","key":"910_CR28","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1093\/rheumatology\/kez435","volume":"58","author":"H Yamashita","year":"2019","unstructured":"Yamashita H, Kamei R, Kaneko H. Classifications of scleroderma renal crisis and reconsideration of its pathophysiology. Rheumatology (Oxford). 2019;58(12):2099\u2013106.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"910_CR29","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3899\/jrheum.171186","volume":"46","author":"S Gordon","year":"2019","unstructured":"Gordon S, Stitt R, Nee R, Bailey W, Little D, Knight K, Hughes J, Edison J, Olson S. Risk Factors for Future Scleroderma Renal Crisis at Systemic Sclerosis Diagnosis. J Rheumatol. 2019;46(1):85\u201392.","journal-title":"J Rheumatol"},{"key":"910_CR30","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.ebiom.2018.07.036","volume":"34","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Yang T, Xiao J. Circular RNAs: Promising Biomarkers for Human Diseases. EBioMedicine. 2018;34:267\u201374.","journal-title":"EBioMedicine"},{"key":"910_CR31","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cca.2017.01.025","volume":"466","author":"S Chen","year":"2017","unstructured":"Chen S, Li T, Zhao Q, Xiao B, Guo J. Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clinica chimica acta Inter J Clin Chem. 2017;466:167\u201371.","journal-title":"Clinica chimica acta Inter J Clin Chem"},{"key":"910_CR32","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.molimm.2018.07.029","volume":"101","author":"Q Ouyang","year":"2018","unstructured":"Ouyang Q, Huanag Q, Jiang Z, Zhao J, Shi G, Yang M. Using plasma circRNA_002453 as a novel biomarker in the diagnosis of lupus nephritis. Mol Immunol. 2018;101:531\u20138.","journal-title":"Mol Immunol"}],"container-title":["BMC Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12896-024-00910-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12896-024-00910-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12896-024-00910-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T21:20:39Z","timestamp":1731532839000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbiotechnol.biomedcentral.com\/articles\/10.1186\/s12896-024-00910-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["910"],"URL":"https:\/\/doi.org\/10.1186\/s12896-024-00910-0","relation":{},"ISSN":["1472-6750"],"issn-type":[{"value":"1472-6750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]},"assertion":[{"value":"1 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments on the use of human blood samples and data were performed in accordance with the Declaration of Helsinki. All experimental protocols, including animals and human, were approved by the Ethics Committee of the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, China (Approval No. 2022 (106)). Informed consent was obtained from all subjects in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"91"}}