{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:16:36Z","timestamp":1794071796428,"version":"4.8.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Biotechnol"],"DOI":"10.1186\/s12896-025-01019-8","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T05:34:59Z","timestamp":1754890499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nano delivery of MiR-146a and its effect study on genes involved in apoptosis and autophagy pathways in lung cancer and tuberculosis"],"prefix":"10.1186","volume":"25","author":[{"given":"Mojgan","family":"Sheikhpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobina","family":"Maleki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanie","family":"Sakhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Movafagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ali","family":"Nojoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Ghazizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"issue":"2","key":"1019_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2217\/imt-2023-0124","volume":"16","author":"H Sakhi","year":"2024","unstructured":"Sakhi H, Arabi M, Ghaemi A, Movafagh A, Sheikhpour M. Oncolytic viruses in lung cancer treatment: a review Article. Immunotherapy. 2024;16(2):75\u201397.","journal-title":"Immunotherapy"},{"key":"1019_CR2","doi-asserted-by":"publisher","first-page":"100967","DOI":"10.1016\/j.genrep.2020.100967","volume":"22","author":"H Abolfathi","year":"2021","unstructured":"Abolfathi H, Sheikhpour M, Mohammad Soltani B, Fahimi H. The comparison and evaluation of the miR-16, miR-155 and miR-146a expression pattern in the blood of TB and NSCLC patients: a research paper. Gene Rep. 2021;22:100967.","journal-title":"Gene Rep"},{"issue":"1","key":"1019_CR3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12931-023-02366-w","volume":"24","author":"H Abolfathi","year":"2023","unstructured":"Abolfathi H, Arabi M, Sheikhpour M. A literature review of MicroRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer. Respir Res. 2023;24(1):55.","journal-title":"Respir Res"},{"issue":"24","key":"1019_CR4","doi-asserted-by":"publisher","first-page":"10591","DOI":"10.7314\/APJCP.2014.15.24.10591","volume":"15","author":"XL Zhang","year":"2014","unstructured":"Zhang XL, Dang YW, Li P, Rong MH, Hou XX, Luo DZ, et al. Expression of tumor necrosis factor receptor-associated factor 6 in lung cancer tissues. Asian Pac J Cancer Prevention: APJCP. 2014;15(24):10591\u20136.","journal-title":"Asian Pac J Cancer Prevention: APJCP"},{"issue":"10","key":"1019_CR5","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.1172\/JCI58818","volume":"121","author":"DT Starczynowski","year":"2011","unstructured":"Starczynowski DT, Lockwood WW, Del\u00e9houz\u00e9e S, Chari R, Wegrzyn J, Fuller M, et al. TRAF6 is an amplified oncogene bridging the RAS and NF-\u03baB pathways in human lung cancer. J Clin Investig. 2011;121(10):4095\u2013105.","journal-title":"J Clin Investig"},{"issue":"10","key":"1019_CR6","doi-asserted-by":"publisher","first-page":"107881","DOI":"10.1016\/j.isci.2023.107881","volume":"26","author":"L Yang","year":"2023","unstructured":"Yang L, Zhuang L, Ye Z, Li L, Guan J, Gong W. Immunotherapy and biomarkers in patients with lung cancer with tuberculosis: recent advances and future directions. iScience. 2023;26(10):107881.","journal-title":"iScience"},{"key":"1019_CR7","doi-asserted-by":"publisher","first-page":"1702819","DOI":"10.1155\/2022\/1702819","volume":"2022","author":"S Bhowmik","year":"2022","unstructured":"Bhowmik S, Mohanto NC, Sarker D, Sorove AA. Incidence and risk of lung cancer in tuberculosis patients, and vice versa: A literature review of the last decade. Biomed Res Int. 2022;2022:1702819.","journal-title":"Biomed Res Int"},{"issue":"2","key":"1019_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/15548627.2017.1389823","volume":"14","author":"AC Racanelli","year":"2018","unstructured":"Racanelli AC, Kikkers SA, Choi AMK, Cloonan SM. Autophagy and inflammation in chronic respiratory disease. Autophagy. 2018;14(2):221\u201332.","journal-title":"Autophagy"},{"issue":"6","key":"1019_CR9","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s00011-020-01346-w","volume":"69","author":"J Shao","year":"2020","unstructured":"Shao J, Ding Z, Peng J, Zhou R, Li L, Qian Q, et al. MiR-146a-5p promotes IL-1\u03b2-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway. Inflamm Res. 2020;69(6):619\u201330.","journal-title":"Inflamm Res"},{"issue":"11","key":"1019_CR10","first-page":"1419","volume":"23","author":"H Ying","year":"2020","unstructured":"Ying H, FengYing S, YanHong W, YouMing H, FaYou Z, HongXiang Z, et al. MicroRNA-155 from sputum as noninvasive biomarker for diagnosis of active pulmonary tuberculosis. Iran J Basic Med Sci. 2020;23(11):1419\u201325.","journal-title":"Iran J Basic Med Sci"},{"issue":"2","key":"1019_CR11","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.canlet.2009.04.031","volume":"285","author":"K Ruan","year":"2009","unstructured":"Ruan K, Fang X, Ouyang G, MicroRNAs. Novel regulators in the hallmarks of human cancer. Cancer Lett. 2009;285(2):116\u201326.","journal-title":"Cancer Lett"},{"key":"1019_CR12","doi-asserted-by":"crossref","unstructured":"M K, S S, S M. Expression levels of candidate circulating MicroRNAs in pediatric tuberculosis. Pathogens Global Health. 2020;114(5):262\u201370.","DOI":"10.1080\/20477724.2020.1761140"},{"key":"1019_CR13","doi-asserted-by":"publisher","first-page":"784330","DOI":"10.3389\/fneur.2021.784330","volume":"12","author":"GA Bonaf\u00e9","year":"2021","unstructured":"Bonaf\u00e9 GA, Boschiero MN, Sodr\u00e9 AR, Ziegler JV, Rocha T, Ortega MM. Natural plant compounds: does caffeine, dipotassium glycyrrhizinate, curcumin, and euphol play roles as antitumoral compounds in glioblastoma cell lines?? Front Neurol. 2021;12:784330.","journal-title":"Front Neurol"},{"key":"1019_CR14","doi-asserted-by":"crossref","unstructured":"Krishnan P, Branco RCS, Weaver SA, Chang G, Lee CC, Syed F, et al. miR-146a-5p mediates inflammation-induced \u03b2 cell mitochondrial dysfunction and apoptosis. bioRxiv: the preprint server for biology. 2024.","DOI":"10.1101\/2024.03.18.585543"},{"key":"1019_CR15","doi-asserted-by":"publisher","first-page":"1094709","DOI":"10.3389\/fneur.2023.1094709","volume":"14","author":"S Mao","year":"2023","unstructured":"Mao S, Wu J, Yan J, Zhang W, Zhu F. Dysregulation of miR-146a: a causative factor in epilepsy pathogenesis, diagnosis, and prognosis. Front Neurol. 2023;14:1094709.","journal-title":"Front Neurol"},{"issue":"3","key":"1019_CR16","first-page":"197","volume":"20","author":"M Sheikhpour","year":"2021","unstructured":"Sheikhpour M, Abolfathi H, Karimipoor M, Movafagh A, Shahsavani M. The common MiRNAs between tuberculosis and Non-Small cell lung cancer: A critical review. Tanaffos. 2021;20(3):197\u2013208.","journal-title":"Tanaffos"},{"key":"1019_CR17","doi-asserted-by":"crossref","unstructured":"Wani JA, Majid S, Khan A, Arafah A, Ahmad A, Jan BL, et al. Clinico-Pathological importance of miR-146a in lung cancer. Diagnostics (Basel). 2021;11(2).","DOI":"10.3390\/diagnostics11020274"},{"issue":"37","key":"1019_CR18","doi-asserted-by":"publisher","first-page":"59287","DOI":"10.18632\/oncotarget.11040","volume":"7","author":"YL Li","year":"2016","unstructured":"Li YL, Wang J, Zhang CY, Shen YQ, Wang HM, Ding L, et al. MiR-146a-5p inhibits cell proliferation and cell cycle progression in NSCLC cell lines by targeting CCND1 and CCND2. Oncotarget. 2016;7(37):59287\u201398.","journal-title":"Oncotarget"},{"issue":"6","key":"1019_CR19","first-page":"3015","volume":"39","author":"Q Hu","year":"2018","unstructured":"Hu Q, Song J, Ding B, Cui Y, Liang J, Han S. miR-146a promotes cervical cancer cell viability via targeting IRAK1 and TRAF6. Oncol Rep. 2018;39(6):3015\u201324.","journal-title":"Oncol Rep"},{"key":"1019_CR20","unstructured":"https:\/\/mpd.bioinf.uni-sb.de\/mirnas.html"},{"issue":"4","key":"1019_CR21","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1159\/000438513","volume":"37","author":"F Zhang","year":"2015","unstructured":"Zhang F, Wang J, Chu J, Yang C, Xiao H, Zhao C, et al. MicroRNA-146a induced by hypoxia promotes chondrocyte autophagy through Bcl-2. Cell Physiol Biochem. 2015;37(4):1442\u201353.","journal-title":"Cell Physiol Biochem"},{"key":"1019_CR22","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3389\/fcell.2020.00847","volume":"8","author":"X Liu","year":"2020","unstructured":"Liu X, Liu B, Li R, Wang F, Wang N, Zhang M, et al. miR-146a-5p plays an oncogenic role in NSCLC via suppression of TRAF6. Front Cell Dev Biology. 2020;8:847.","journal-title":"Front Cell Dev Biology"},{"issue":"6","key":"1019_CR23","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.jinf.2013.12.017","volume":"68","author":"Z Liu","year":"2014","unstructured":"Liu Z, Zhou G, Deng X, Yu Q, Hu Y, Sun H, et al. Analysis of MiRNA expression profiling in human macrophages responding to Mycobacterium infection: induction of the immune regulator miR-146a. J Infect. 2014;68(6):553\u201361.","journal-title":"J Infect"},{"key":"1019_CR24","doi-asserted-by":"crossref","unstructured":"McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ et al. Attenuation of inflammatory mediator production by the NF-\u03baB member RelB is mediated by microRNA-146a in lung fibroblasts. 2013;304(11):L774\u201381.","DOI":"10.1152\/ajplung.00352.2012"},{"key":"1019_CR25","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.msec.2017.02.132","volume":"76","author":"M Sheikhpour","year":"2017","unstructured":"Sheikhpour M, Golbabaie A, Kasaeian A. Carbon nanotubes: A review of novel strategies for cancer diagnosis and treatment. Mater Sci Engineering: C. 2017;76:1289\u2013304.","journal-title":"Mater Sci Engineering: C"},{"issue":"1","key":"1019_CR26","doi-asserted-by":"publisher","first-page":"24419","DOI":"10.1038\/s41598-021-03031-2","volume":"11","author":"FM Kamazani","year":"2021","unstructured":"Kamazani FM, Sotoodehnejad nematalahi F, Siadat SD, Pornour M, Sheikhpour M. A success targeted nano delivery to lung cancer cells with multi-walled carbon nanotubes conjugated to Bromocriptine. Sci Rep. 2021;11(1):24419.","journal-title":"Sci Rep"},{"key":"1019_CR27","doi-asserted-by":"publisher","first-page":"5901","DOI":"10.2147\/IJN.S251524","volume":"15","author":"S Zomorodbakhsh","year":"2020","unstructured":"Zomorodbakhsh S, Abbasian Y, Naghinejad M, Sheikhpour M. The effects study of Isoniazid conjugated multi-wall carbon nanotubes nanofluid on Mycobacterium tuberculosis. Int J Nanomed. 2020;15:5901\u20139.","journal-title":"Int J Nanomed"},{"key":"1019_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.colsurfb.2015.12.021","volume":"140","author":"S Taghavi","year":"2016","unstructured":"Taghavi S, HashemNia A, Mosaffa F, Askarian S, Abnous K, Ramezani M. Preparation and evaluation of polyethylenimine-functionalized carbon nanotubes tagged with 5TR1 aptamer for targeted delivery of Bcl-xL ShRNA into breast cancer cells. Colloids Surf B. 2016;140:28\u201339.","journal-title":"Colloids Surf B"},{"key":"1019_CR29","unstructured":"https: \/\/bonbiotech.ir\/ \n                  \n                \/pbon-lenti-iii-mir-egfp\/"},{"key":"1019_CR30","doi-asserted-by":"crossref","unstructured":"Lakshmanan I, Batra SK. Protocol for apoptosis assay by flow cytometry using Annexin V staining method. Bio-protocol. 2013;3(6).","DOI":"10.21769\/BioProtoc.374"},{"issue":"2","key":"1019_CR31","first-page":"126","volume":"20","author":"M Sheikhpour","year":"2021","unstructured":"Sheikhpour M, Shokrgozar MA, Biglari A, Pornour M, Abdolrahimi F, Poorazar Dizaji S, et al. Gene expression and in vitro Pharmacogenetic studies of dopamine and serotonin gene receptors in tuberculosis. Tanaffos. 2021;20(2):126\u201333.","journal-title":"Tanaffos"},{"issue":"4","key":"1019_CR32","doi-asserted-by":"publisher","first-page":"e309","DOI":"10.1002\/mco2.309","volume":"4","author":"Y Guo","year":"2023","unstructured":"Guo Y, Zhang X, Li J, Zhou Z, Zhu S, Liu W, et al. TRAF6 regulates autophagy and apoptosis of melanoma cells through c-Jun\/ATG16L2 signaling pathway. MedComm. 2023;4(4):e309.","journal-title":"MedComm"},{"key":"1019_CR33","doi-asserted-by":"crossref","unstructured":"Xu H, Li L, Dong B, Lu J, Zhou K, Yin X et al. TRAF6 promotes chemoresistance to Paclitaxel of triple negative breast cancer via regulating PKM2-mediated Glycolysis. 2022.","DOI":"10.21203\/rs.3.rs-2393717\/v1"},{"key":"1019_CR34","first-page":"71","volume":"14","author":"AI Fahira","year":"2022","unstructured":"Fahira AI, Amalia R, Barliana MI, Gatera VA, Abdulah R. Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery system for breast cancer therapy. Breast Cancer (Dove Med Press). 2022;14:71\u201383.","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"1019_CR35","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.colsurfb.2014.06.056","volume":"122","author":"H Moradian","year":"2014","unstructured":"Moradian H, Fasehee H, Keshvari H, Faghihi S. Poly(ethyleneimine) functionalized carbon nanotubes as efficient nano-vector for transfecting mesenchymal stem cells. Colloids Surf B. 2014;122:115\u201325.","journal-title":"Colloids Surf B"},{"issue":"20","key":"1019_CR36","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1002\/smll.201000864","volume":"6","author":"A Nunes","year":"2010","unstructured":"Nunes A, Amsharov N, Guo C, Van den Bossche J, Santhosh P, Karachalios TK, et al. Hybrid polymer-grafted multiwalled carbon nanotubes for in vitro gene delivery. Small. 2010;6(20):2281\u201391.","journal-title":"Small"},{"issue":"20","key":"1019_CR37","doi-asserted-by":"publisher","first-page":"5369","DOI":"10.1016\/j.biomaterials.2014.03.038","volume":"35","author":"H Wu","year":"2014","unstructured":"Wu H, Shi H, Zhang H, Wang X, Yang Y, Yu C, et al. Prostate stem cell antigen antibody-conjugated multiwalled carbon nanotubes for targeted ultrasound imaging and drug delivery. Biomaterials. 2014;35(20):5369\u201380.","journal-title":"Biomaterials"},{"issue":"16","key":"1019_CR38","doi-asserted-by":"publisher","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","volume":"92","author":"O Boussif","year":"1995","unstructured":"Boussif O, Lezoualc\u2019h F, Zanta MA, Mergny MD, Scherman D, Demeneix B, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA. 1995;92(16):7297\u2013301.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1\u20132","key":"1019_CR39","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ijpharm.2018.06.026","volume":"547","author":"QY Zhang","year":"2018","unstructured":"Zhang QY, Ho PY, Tu MJ, Jilek JL, Chen QX, Zeng S, et al. Lipidation of polyethylenimine-based polyplex increases serum stability of bioengineered RNAi agents and offers more consistent tumoral gene knockdown in vivo. Int J Pharm. 2018;547(1\u20132):537\u201344.","journal-title":"Int J Pharm"},{"issue":"6","key":"1019_CR40","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.nano.2016.02.017","volume":"12","author":"A Masotti","year":"2016","unstructured":"Masotti A, Miller MR, Celluzzi A, Rose L, Micciulla F, Hadoke PW, et al. Regulation of angiogenesis through the efficient delivery of MicroRNAs into endothelial cells using polyamine-coated carbon nanotubes. Nanomedicine: Nanatechnol Biology Med. 2016;12(6):1511\u201322.","journal-title":"Nanomedicine: Nanatechnol Biology Med"},{"issue":"10","key":"1019_CR41","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1016\/j.biomaterials.2013.12.079","volume":"35","author":"KS Siu","year":"2014","unstructured":"Siu KS, Chen D, Zheng X, Zhang X, Johnston N, Liu Y, et al. Non-covalently functionalized single-walled carbon nanotube for topical SiRNA delivery into melanoma. Biomaterials. 2014;35(10):3435\u201342.","journal-title":"Biomaterials"},{"issue":"16","key":"1019_CR42","doi-asserted-by":"publisher","first-page":"4933","DOI":"10.1158\/1078-0432.CCR-05-2831","volume":"12","author":"Z Zhang","year":"2006","unstructured":"Zhang Z, Yang X, Zhang Y, Zeng B, Wang S, Zhu T, et al. Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged Single-Walled carbon nanotubes suppresses tumor growth. Clin Cancer Res. 2006;12(16):4933\u20139.","journal-title":"Clin Cancer Res"},{"key":"1019_CR43","doi-asserted-by":"crossref","unstructured":"Zhong J-H, Li J, Liu C-F, Liu N, Bian R-X, Zhao S-M, et al. Effects of microRNA-146a on the proliferation and apoptosis of human osteoarthritis chondrocytes by targeting TRAF6 through the NF-\u03baB signalling pathway. Biosci Rep. 2017;37(2).","DOI":"10.1042\/BSR20160578"},{"issue":"11","key":"1019_CR44","first-page":"2502","volume":"6","author":"Y Zu","year":"2016","unstructured":"Zu Y, Yang Y, Zhu J, Bo X, Hou S, Zhang B, et al. MiR-146a suppresses hepatocellular carcinoma by downregulating TRAF6. Am J Cancer Res. 2016;6(11):2502\u201313.","journal-title":"Am J Cancer Res"},{"issue":"14","key":"1019_CR45","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.1158\/1078-0432.CCR-11-0494","volume":"17","author":"JH Paik","year":"2011","unstructured":"Paik JH, Jang JY, Jeon YK, Kim WY, Kim TM, Heo DS, et al. MicroRNA-146a downregulates NF\u03baB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK\/T cell lymphoma. Clin Cancer Research: Official J Am Association Cancer Res. 2011;17(14):4761\u201371.","journal-title":"Clin Cancer Research: Official J Am Association Cancer Res"},{"issue":"6","key":"1019_CR46","first-page":"3643","volume":"19","author":"F Yuan","year":"2020","unstructured":"Yuan F, Zhang S, Xie W, Yang S, Lin T, Chen X. Effect and mechanism of miR-146a on malignant biological behaviors of lung adenocarcinoma cell line. Oncol Lett. 2020;19(6):3643\u201352.","journal-title":"Oncol Lett"},{"issue":"6","key":"1019_CR47","first-page":"7745","volume":"14","author":"L Pang","year":"2017","unstructured":"Pang L, Lu J, Huang J, Xu C, Li H, Yuan G, et al. Upregulation of miR-146a increases cisplatin sensitivity of the non-small cell lung cancer A549 cell line by targeting JNK-2. Oncol Lett. 2017;14(6):7745\u201352.","journal-title":"Oncol Lett"},{"issue":"16","key":"1019_CR48","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1016\/j.febslet.2012.06.004","volume":"586","author":"Z Wu","year":"2012","unstructured":"Wu Z, Lu H, Sheng J, Li L. Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2. FEBS Lett. 2012;586(16):2459\u201367.","journal-title":"FEBS Lett"},{"issue":"4","key":"1019_CR49","doi-asserted-by":"publisher","first-page":"e1533","DOI":"10.1002\/wrna.1533","volume":"10","author":"JR Iacona","year":"2019","unstructured":"Iacona JR, Lutz CS. miR-146a-5p: expression, regulation, and functions in cancer. Wiley Interdiscip Rev RNA. 2019;10(4):e1533.","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"3","key":"1019_CR50","doi-asserted-by":"publisher","first-page":"e60317","DOI":"10.1371\/journal.pone.0060317","volume":"8","author":"G Chen","year":"2013","unstructured":"Chen G, Umelo IA, Lv S, Teugels E, Fostier K, Kronenberger P, et al. miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells. PLoS ONE. 2013;8(3):e60317.","journal-title":"PLoS ONE"},{"issue":"8","key":"1019_CR51","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.apjtm.2016.06.001","volume":"9","author":"W-M Wang","year":"2016","unstructured":"Wang W-M, Liu J-C. Effect and molecular mechanism of mir-146a on proliferation of lung cancer cells by targeting and regulating MIF gene. Asian Pac J Trop Med. 2016;9(8):806\u201311.","journal-title":"Asian Pac J Trop Med"},{"key":"1019_CR52","doi-asserted-by":"crossref","unstructured":"Chauhan D, Davuluri KS. MicroRNAs associated with the pathogenesis and their role in regulating various signaling pathways during Mycobacterium tuberculosis infection. Front Cell Infect Microbiol. 2022;12.","DOI":"10.3389\/fcimb.2022.1009901"},{"issue":"12","key":"1019_CR53","doi-asserted-by":"publisher","first-page":"e81438","DOI":"10.1371\/journal.pone.0081438","volume":"8","author":"S Li","year":"2013","unstructured":"Li S, Yue Y, Xu W, Xiong S. MicroRNA-146a represses mycobacteria-induced inflammatory response and facilitates bacterial replication via targeting IRAK-1 and TRAF-6. PLoS ONE. 2013;8(12):e81438.","journal-title":"PLoS ONE"},{"issue":"8","key":"1019_CR54","first-page":"1749","volume":"52","author":"E Alijani","year":"2023","unstructured":"Alijani E, Rad FR, Katebi A, Ajdary S. Differential expression of miR-146 and miR-155 in active and latent tuberculosis infection. Iran J Public Health. 2023;52(8):1749\u201357.","journal-title":"Iran J Public Health"}],"container-title":["BMC Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12896-025-01019-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12896-025-01019-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12896-025-01019-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:13:41Z","timestamp":1757376821000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbiotechnol.biomedcentral.com\/articles\/10.1186\/s12896-025-01019-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1019"],"URL":"https:\/\/doi.org\/10.1186\/s12896-025-01019-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6454179\/v1","asserted-by":"object"}]},"ISSN":["1472-6750"],"issn-type":[{"value":"1472-6750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"15 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"81"}}