{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T22:23:11Z","timestamp":1794608591156,"version":"4.9.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100008323","name":"Zanjan University of Medical Sciences","doi-asserted-by":"publisher","award":["Grant Number: A-12-1244-26 & Ethical Code: IR.ZUMS.BLC.1402.029"],"award-info":[{"award-number":["Grant Number: A-12-1244-26 & Ethical Code: IR.ZUMS.BLC.1402.029"]}],"id":[{"id":"10.13039\/501100008323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Biotechnol"],"DOI":"10.1186\/s12896-025-01027-8","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:49:40Z","timestamp":1756280980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anticancer effects of folic acid-functionalized covalent organic framework containing doxorubicin on SW480 colon cancer cells: a promising tool for drug targeted delivery"],"prefix":"10.1186","volume":"25","author":[{"given":"Razie","family":"Ezati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrooz","family":"Johari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaber Yousefi","family":"Seyf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Mortazavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Samadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"issue":"8","key":"1027_CR1","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.3390\/cancers16081530","volume":"16","author":"G Roshandel","year":"2024","unstructured":"Roshandel G, Ghasemi-Kebria F, Malekzadeh R. Colorectal cancer: epidemiology, risk factors, and prevention. Cancers. 2024;16(8):1530.","journal-title":"Cancers"},{"issue":"7","key":"1027_CR2","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.3390\/cancers14071732","volume":"14","author":"MS Hossain","year":"2022","unstructured":"Hossain MS, Karuniawati H, Jairoun AA, Urbi Z, Ooi DJ, John A, et al. Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers. 2022;14(7):1732.","journal-title":"Cancers"},{"issue":"3","key":"1027_CR3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/nrclinonc.2013.12","volume":"10","author":"EJ Kuipers","year":"2013","unstructured":"Kuipers EJ, R\u00f6sch T, Bretthauer M. Colorectal cancer screening\u2013optimizing current strategies and new directions. Nat Rev Clin Oncol. 2013;10(3):130\u201342.","journal-title":"Nat Rev Clin Oncol"},{"issue":"2","key":"1027_CR4","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jconrel.2010.04.006","volume":"146","author":"S Cai","year":"2010","unstructured":"Cai S, Thati S, Bagby TR, Diab HM, Davies NM, Cohen MS, et al. Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer. J Control Release. 2010;146(2):212\u20138.","journal-title":"J Control Release"},{"issue":"5","key":"1027_CR5","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3390\/cells13050388","volume":"13","author":"EV Sazonova","year":"2024","unstructured":"Sazonova EV, Yapryntseva MA, Pervushin NV, Tsvetcov RI, Zhivotovsky B, Kopeina GS. Cancer drug resistance: targeting proliferation or programmed cell death. Cells. 2024;13(5):388.","journal-title":"Cells"},{"issue":"2","key":"1027_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1124\/pr.56.2.6","volume":"56","author":"G Minotti","year":"2004","unstructured":"Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L. Anthracyclines: molecular advances and Pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004;56(2):185.","journal-title":"Pharmacol Rev"},{"key":"1027_CR7","doi-asserted-by":"publisher","first-page":"110525","DOI":"10.1016\/j.biopha.2020.110525","volume":"130","author":"A Xu","year":"2020","unstructured":"Xu A, Deng F, Chen Y, Kong Y, Pan L, Liao Q, et al. NF-\u03baB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity. Biomed Pharmacother. 2020;130:110525.","journal-title":"Biomed Pharmacother"},{"issue":"16","key":"1027_CR8","first-page":"4592","volume":"62","author":"AC Childs","year":"2002","unstructured":"Childs AC, Phaneuf SL, Dirks AJ, Phillips T, Leeuwenburgh C. Doxorubicin treatment in vivo causes cytochrome c release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax Ratio1. Cancer Res. 2002;62(16):4592\u20138.","journal-title":"Cancer Res"},{"issue":"3","key":"1027_CR9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1023\/B:BREA.0000004377.12288.3c","volume":"82","author":"GN Naumov","year":"2003","unstructured":"Naumov GN, Townson JL, MacDonald IC, Wilson SM, Bramwell VH, Groom AC, et al. Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases. Breast Cancer Res Treat. 2003;82(3):199\u2013206.","journal-title":"Breast Cancer Res Treat"},{"issue":"12","key":"1027_CR10","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.3390\/pharmaceutics16121582","volume":"16","author":"C Feng","year":"2024","unstructured":"Feng C, Wang Y, Xu J, Zheng Y, Zhou W, Wang Y, et al. Precisely tailoring molecular structure of doxorubicin prodrugs to enable stable nanoassembly, rapid activation, and potent antitumor effect. Pharmaceutics. 2024;16(12):1582.","journal-title":"Pharmaceutics"},{"issue":"17","key":"1027_CR11","doi-asserted-by":"publisher","first-page":"4315","DOI":"10.1002\/chem.201806242","volume":"25","author":"S Liu","year":"2019","unstructured":"Liu S, Hu C, Liu Y, Zhao X, Pang M, Lin J. One-Pot synthesis of dox@covalent organic framework with enhanced chemotherapeutic efficacy. Chem \u2013 Eur J. 2019;25(17):4315\u20139.","journal-title":"Chem \u2013 Eur J"},{"issue":"4","key":"1027_CR12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1039\/C9CC08217D","volume":"56","author":"B Wang","year":"2020","unstructured":"Wang B, Liu X, Gong P, Ge X, Liu Z, You J. Fluorescent COFs with a highly conjugated structure for visual drug loading and responsive release. Chem Commun. 2020;56(4):519\u201322.","journal-title":"Chem Commun"},{"issue":"1","key":"1027_CR13","doi-asserted-by":"publisher","first-page":"6786","DOI":"10.1038\/ncomms7786","volume":"6","author":"S Kandambeth","year":"2015","unstructured":"Kandambeth S, Venkatesh V, Shinde DB, Kumari S, Halder A, Verma S, et al. Self-templated chemically stable Hollow spherical covalent organic framework. Nat Commun. 2015;6(1):6786.","journal-title":"Nat Commun"},{"key":"1027_CR14","doi-asserted-by":"crossref","unstructured":"Jarju JJ, Lavender AM, Espi\u00f1a B, Romero V, Salonen LM. Covalent organic framework composites: synthesis and analytical applications. Molecules [Internet]. 2020; 25(22).","DOI":"10.3390\/molecules25225404"},{"issue":"1","key":"1027_CR15","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1038\/s41467-018-04910-5","volume":"9","author":"G Zhang","year":"2018","unstructured":"Zhang G, Li X, Liao Q, Liu Y, Xi K, Huang W, et al. Water-dispersible PEG-curcumin\/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery. Nat Commun. 2018;9(1):2785.","journal-title":"Nat Commun"},{"issue":"17","key":"1027_CR16","doi-asserted-by":"publisher","first-page":"4315","DOI":"10.1002\/chem.201806242","volume":"25","author":"S Liu","year":"2019","unstructured":"Liu S, Hu C, Liu Y, Zhao X, Pang M, Lin J. One-pot synthesis of DOX@ covalent organic framework with enhanced chemotherapeutic efficacy. Chemistry\u2013A Eur J. 2019;25(17):4315\u20139.","journal-title":"Chemistry\u2013A Eur J"},{"issue":"44","key":"1027_CR17","doi-asserted-by":"publisher","first-page":"18782","DOI":"10.1021\/jacs.0c05381","volume":"142","author":"F Benyettou","year":"2020","unstructured":"Benyettou F, Das G, Nair AR, Prakasam T, Shinde DB, Sharma SK, et al. Covalent organic framework embedded with magnetic nanoparticles for MRI and chemo-thermotherapy. J Am Chem Soc. 2020;142(44):18782\u201394.","journal-title":"J Am Chem Soc"},{"issue":"9","key":"1027_CR18","doi-asserted-by":"publisher","first-page":"2300077","DOI":"10.1002\/mabi.202300077","volume":"23","author":"R Solanki","year":"2023","unstructured":"Solanki R, Jangid AK, Jadav M, Kulhari H, Patel S. Folate functionalized and evodiamine-loaded pluronic nanomicelles for augmented cervical cancer cell killing. Macromol Biosci. 2023;23(9):2300077.","journal-title":"Macromol Biosci"},{"issue":"11","key":"1027_CR19","doi-asserted-by":"publisher","first-page":"7338","DOI":"10.1039\/D3RA08434E","volume":"14","author":"R Solanki","year":"2024","unstructured":"Solanki R, Srivastav AK, Patel S, Singh SK, Jodha B, Kumar U, et al. Folate conjugated albumin as a targeted nanocarrier for the delivery of fisetin: in Silico and in vitro biological studies. RSC Adv. 2024;14(11):7338\u201349.","journal-title":"RSC Adv"},{"issue":"3","key":"1027_CR20","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1002\/smll.201101909","volume":"8","author":"W Gao","year":"2012","unstructured":"Gao W, Kagan D, Pak OS, Clawson C, Campuzano S, Chuluun-Erdene E, et al. Cargo\u2010towing fuel\u2010free magnetic nanoswimmers for targeted drug delivery. Small. 2012;8(3):460\u20137.","journal-title":"Small"},{"issue":"1","key":"1027_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.32604\/or.2023.044741","volume":"32","author":"R Ghorbani","year":"2023","unstructured":"Ghorbani R, Gharbavi M, Sharafi A, Rismani E, Rezaeejam H, Mortazavi Y, et al. Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells. Oncol Res. 2023;32(1):101.","journal-title":"Oncol Res"},{"issue":"1","key":"1027_CR22","doi-asserted-by":"publisher","first-page":"e6926","DOI":"10.1002\/aoc.6926","volume":"37","author":"M Gharbavi","year":"2023","unstructured":"Gharbavi M, Johari B, Ghorbani R, Madanchi H, Sharafi A. Green synthesis of Zn nanoparticles and in situ hybridized with BSA nanoparticles for Baicalein targeted delivery mediated with glutamate receptors to U87-MG cancer cell lines. Appl Organomet Chem. 2023;37(1):e6926.","journal-title":"Appl Organomet Chem"},{"key":"1027_CR23","doi-asserted-by":"crossref","unstructured":"Johari B, Tavangar-Roosta S, Gharbavi M, Sharafi A, Kaboli S, Rezaeejam H. Suppress the cell growth of cancer stem-like cells (NTERA-2) using Sox2-Oct4 decoy oligodeoxynucleotide \u2013 encapsulated niosomes-zinc hybrid nanocarriers under X-irradiation. Heliyon. 2024;10(13).","DOI":"10.1016\/j.heliyon.2024.e34096"},{"key":"1027_CR24","doi-asserted-by":"publisher","first-page":"124285","DOI":"10.1016\/j.ijpharm.2024.124285","volume":"659","author":"N Asadi","year":"2024","unstructured":"Asadi N, Gharbavi M, Rezaeejam H, Farajollahi A, Johari B. Zinc nanoparticles coated with doxorubicin-conjugated alginate as a radiation sensitizer in triple-negative breast cancer cells. Int J Pharm. 2024;659:124285.","journal-title":"Int J Pharm"},{"issue":"2","key":"1027_CR25","doi-asserted-by":"publisher","first-page":"309","DOI":"10.32604\/or.2023.043576","volume":"32","author":"B Johari","year":"2023","unstructured":"Johari B, Leilan MP, Gharbavi M, Mortazavi Y, Sharafi A, Rezaeejam H. Combinational therapy with Myc decoy oligodeoxynucleotides encapsulated in nanocarrier and X-irradiation on breast cancer cells. Oncol Res. 2023;32(2):309.","journal-title":"Oncol Res"},{"issue":"9","key":"1027_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00604-021-04956-1","volume":"188","author":"F Pan","year":"2021","unstructured":"Pan F, Tong C, Wang Z, Han H, Liu P, Pan D, et al. Nanocomposite based on graphene and intercalated covalent organic frameworks with hydrosulphonyl groups for electrochemical determination of heavy metal ions. Microchim Acta. 2021;188(9):295.","journal-title":"Microchim Acta"},{"issue":"44","key":"1027_CR27","doi-asserted-by":"publisher","first-page":"18881","DOI":"10.1039\/C4TA04429K","volume":"2","author":"G Li","year":"2014","unstructured":"Li G, Zhang B, Yan J, Wang Z. Micro-and mesoporous Poly (Schiff-base) s constructed from different Building blocks and their adsorption behaviors towards organic vapors and CO 2 gas. J Mater Chem A. 2014;2(44):18881\u20138.","journal-title":"J Mater Chem A"},{"key":"1027_CR28","doi-asserted-by":"publisher","first-page":"140154","DOI":"10.1016\/j.cej.2022.140154","volume":"454","author":"Q Fu","year":"2023","unstructured":"Fu Q, Zhang T, Sun X, Zhang S, Waterhouse GI, Sun C, et al. Pyridine-based covalent organic framework for efficient and selective removal of hg (II) from water: adsorption behavior and adsorption mechanism investigations. Chem Eng J. 2023;454:140154.","journal-title":"Chem Eng J"},{"issue":"32","key":"1027_CR29","doi-asserted-by":"publisher","first-page":"18959","DOI":"10.1039\/C9TA06214A","volume":"7","author":"Q Liao","year":"2019","unstructured":"Liao Q, Ke C, Huang X, Zhang G, Zhang Q, Zhang Z, et al. Catalyst-free and efficient fabrication of highly crystalline fluorinated covalent organic frameworks for selective guest adsorption. J Mater Chem A. 2019;7(32):18959\u201370.","journal-title":"J Mater Chem A"},{"key":"1027_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0927-7757(01)00612-4","volume":"187","author":"K Sing","year":"2001","unstructured":"Sing K. The use of nitrogen adsorption for the characterisation of porous materials. Colloids Surf A. 2001;187:3\u20139.","journal-title":"Colloids Surf A"},{"issue":"10","key":"1027_CR31","doi-asserted-by":"publisher","first-page":"e202400131","DOI":"10.1002\/cptc.202400131","volume":"8","author":"M Shahid","year":"2024","unstructured":"Shahid M, ur Rehman A, Najam T, Majeed H, Shalash M, El-Bahy SM, et al. Covalent organic frameworks: synthesis and applications for photocatalysis. ChemPhotoChem. 2024;8(10):e202400131.","journal-title":"ChemPhotoChem"},{"issue":"10","key":"1027_CR32","doi-asserted-by":"publisher","first-page":"13952","DOI":"10.1021\/acsomega.8b01619","volume":"3","author":"KR Bittleman","year":"2018","unstructured":"Bittleman KR, Dong S, Roman M, Lee YW. Folic acid-conjugated cellulose nanocrystals show high folate-receptor binding affinity and uptake by KB and breast cancer cells. ACS Omega. 2018;3(10):13952\u20139.","journal-title":"ACS Omega"},{"issue":"5","key":"1027_CR33","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1021\/bm401593n","volume":"15","author":"S Dong","year":"2014","unstructured":"Dong S, Cho HJ, Lee YW, Roman M. Synthesis and cellular uptake of folic acid-conjugated cellulose nanocrystals for cancer targeting. Biomacromolecules. 2014;15(5):1560\u20137.","journal-title":"Biomacromolecules"},{"issue":"1","key":"1027_CR34","doi-asserted-by":"publisher","first-page":"12722","DOI":"10.1038\/srep12722","volume":"5","author":"B Gnapareddy","year":"2015","unstructured":"Gnapareddy B, Reddy Dugasani S, Ha T, Paulson B, Hwang T, Kim T, et al. Chemical and physical characteristics of doxorubicin hydrochloride drug-doped salmon DNA thin films. Sci Rep. 2015;5(1):12722.","journal-title":"Sci Rep"},{"key":"1027_CR35","doi-asserted-by":"publisher","first-page":"102316","DOI":"10.1016\/j.jddst.2020.102316","volume":"61","author":"M Nikzamir","year":"2021","unstructured":"Nikzamir M, Akbarzadeh A, Panahi Y. An overview on nanoparticles used in biomedicine and their cytotoxicity. J Drug Deliv Sci Technol. 2021;61:102316.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"7","key":"1027_CR36","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.3390\/biomedicines11071862","volume":"11","author":"JM Domingues","year":"2023","unstructured":"Domingues JM, Miranda CS, Homem NC, Felgueiras HP, Antunes JC. Nanoparticle synthesis and their integration into polymer-based fibers for biomedical applications. Biomedicines. 2023;11(7):1862.","journal-title":"Biomedicines"},{"issue":"2","key":"1027_CR37","doi-asserted-by":"publisher","first-page":"152317","DOI":"10.1016\/j.imbio.2022.152317","volume":"228","author":"K Pondman","year":"2023","unstructured":"Pondman K, Le Gac S, Kishore U. Nanoparticle-induced immune response: health risk versus treatment opportunity? Immunobiology. 2023;228(2):152317.","journal-title":"Immunobiology"},{"key":"1027_CR38","doi-asserted-by":"publisher","first-page":"104063","DOI":"10.1016\/j.pdpdt.2024.104063","volume":"46","author":"P Chen","year":"2024","unstructured":"Chen P, Li Y, Dai Y, Wang Z, Zhou Y, Wang Y, et al. Porphyrin-based covalent organic frameworks as doxorubicin delivery system for chemo-photodynamic synergistic therapy of tumors. Photodiagn Photodyn Ther. 2024;46:104063.","journal-title":"Photodiagn Photodyn Ther"},{"key":"1027_CR39","doi-asserted-by":"publisher","first-page":"138864","DOI":"10.1016\/j.cej.2022.138864","volume":"451","author":"S Wang","year":"2023","unstructured":"Wang S, Pang Y, Hu S, Lv J, Lin Y, Li M. Copper sulfide engineered covalent organic frameworks for pH-responsive chemo\/photothermal\/chemodynamic synergistic therapy against cancer. Chem Eng J. 2023;451:138864.","journal-title":"Chem Eng J"},{"issue":"13","key":"1027_CR40","doi-asserted-by":"publisher","first-page":"4570","DOI":"10.1021\/ja8096256","volume":"131","author":"FJ Uribe-Romo","year":"2009","unstructured":"Uribe-Romo FJ, Hunt JR, Furukawa H, Klock C, O\u2019Keeffe M, Yaghi OM. A crystalline imine-linked 3-D porous covalent organic framework. J Am Chem Soc. 2009;131(13):4570\u20131.","journal-title":"J Am Chem Soc"},{"issue":"37","key":"1027_CR41","doi-asserted-by":"publisher","first-page":"12911","DOI":"10.1021\/jacs.7b06913","volume":"139","author":"E Vitaku","year":"2017","unstructured":"Vitaku E, Dichtel WR. Synthesis of 2D imine-linked covalent organic frameworks through formal transimination reactions. J Am Chem Soc. 2017;139(37):12911\u20134.","journal-title":"J Am Chem Soc"},{"issue":"25","key":"1027_CR42","doi-asserted-by":"publisher","first-page":"12657","DOI":"10.1039\/D0TA01037E","volume":"8","author":"H-J Da","year":"2020","unstructured":"Da H-J, Yang C-X, Qian H-L, Yan X-P. A knot-linker planarity control strategy for constructing highly crystalline cationic covalent organic frameworks: decoding the effect of crystallinity on adsorption performance. J Mater Chem A. 2020;8(25):12657\u201364.","journal-title":"J Mater Chem A"},{"issue":"33","key":"1027_CR43","doi-asserted-by":"publisher","first-page":"4899","DOI":"10.1039\/C7CE00344G","volume":"19","author":"J Dong","year":"2017","unstructured":"Dong J, Wang Y, Liu G, Cheng Y, Zhao D. Isoreticular covalent organic frameworks for hydrocarbon uptake and separation: the important role of monomer planarity. CrystEngComm. 2017;19(33):4899\u2013904.","journal-title":"CrystEngComm"},{"issue":"5","key":"1027_CR44","doi-asserted-by":"publisher","first-page":"7085","DOI":"10.1007\/s12274-022-5265-7","volume":"16","author":"Y Yu","year":"2023","unstructured":"Yu Y, Zhang G, Li Z, Wang J, Liu Y, Bhardwaj R, et al. Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy. Nano Res. 2023;16(5):7085\u201394.","journal-title":"Nano Res"},{"issue":"17","key":"1027_CR45","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.3390\/nano12173055","volume":"12","author":"F Zhou","year":"2022","unstructured":"Zhou F, Fang Y, Deng C, Zhang Q, Wu M, Shen H-H, et al. Templated assembly of pH-labile covalent organic framework hierarchical particles for intracellular drug delivery. Nanomaterials. 2022;12(17):3055.","journal-title":"Nanomaterials"},{"issue":"27","key":"1027_CR46","doi-asserted-by":"publisher","first-page":"22856","DOI":"10.1021\/acsami.7b05870","volume":"9","author":"M Mu","year":"2017","unstructured":"Mu M, Wang Y, Qin Y, Yan X, Li Y, Chen L. Two-dimensional imine-linked covalent organic frameworks as a platform for selective oxidation of olefins. ACS Appl Mater Interfaces. 2017;9(27):22856\u201363.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"1","key":"1027_CR47","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13045-022-01320-5","volume":"15","author":"H Tian","year":"2022","unstructured":"Tian H, Zhang T, Qin S, Huang Z, Zhou L, Shi J, et al. Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies. J Hematol Oncol. 2022;15(1):132.","journal-title":"J Hematol Oncol"},{"issue":"46","key":"1027_CR48","doi-asserted-by":"publisher","first-page":"7441","DOI":"10.1039\/C6TB00746E","volume":"4","author":"M Mahdavi","year":"2016","unstructured":"Mahdavi M, Rahmani F, Nouranian S. Molecular simulation of pH-dependent diffusion, loading, and release of doxorubicin in graphene and graphene oxide drug delivery systems. J Mater Chem B. 2016;4(46):7441\u201351.","journal-title":"J Mater Chem B"},{"issue":"4","key":"1027_CR49","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1039\/C7SC04004K","volume":"9","author":"M Fern\u00e1ndez","year":"2018","unstructured":"Fern\u00e1ndez M, Javaid F, Chudasama V. Advances in targeting the folate receptor in the treatment\/imaging of cancers. Chem Sci. 2018;9(4):790\u2013810.","journal-title":"Chem Sci"},{"key":"1027_CR50","doi-asserted-by":"crossref","unstructured":"Kciuk M, Gieleci\u0144ska A, Mujwar S, Ko\u0142at D, Ka\u0142uzi\u0144ska-Ko\u0142at \u017b, Celik I et al. Doxorubicin-An agent with multiple mechanisms of anticancer activity. Cells. 2023;12(4).","DOI":"10.3390\/cells12040659"},{"issue":"25","key":"1027_CR51","doi-asserted-by":"publisher","first-page":"5583","DOI":"10.1002\/chem.201905150","volume":"26","author":"Q Guan","year":"2020","unstructured":"Guan Q, Zhou LL, Li WY, Li YA, Dong YB. Covalent organic frameworks (COFs) for cancer therapeutics. Chemistry\u2013A Eur J. 2020;26(25):5583\u201391.","journal-title":"Chemistry\u2013A Eur J"},{"key":"1027_CR52","doi-asserted-by":"crossref","unstructured":"Yu Y, Zhang G, Li Z, Wang J, Liu Y, Bhardwaj R, et al. Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy. Nano Res. 2023;16(5):7085\u201394.","DOI":"10.1007\/s12274-022-5265-7"},{"key":"1027_CR53","doi-asserted-by":"crossref","unstructured":"Qiu L, Dong C, Kan X. Lymphoma-targeted treatment using a folic acid-decorated vincristine-loaded drug delivery system. Drug design, development and therapy. 2018:863\u2009\u2013\u200972.","DOI":"10.2147\/DDDT.S152420"},{"key":"1027_CR54","doi-asserted-by":"publisher","first-page":"116828","DOI":"10.1016\/j.biopha.2024.116828","volume":"176","author":"C Fu","year":"2024","unstructured":"Fu C, Gong S, Lin L, Bao Y, Li L, Chen Q. Characterization and efficacy of C60 nano-photosensitive drugs in colorectal cancer treatment. Biomed Pharmacother. 2024;176:116828.","journal-title":"Biomed Pharmacother"},{"key":"1027_CR55","doi-asserted-by":"crossref","unstructured":"Park E-J, Kwon H-K, Choi Y-M, Shin H-J, Choi S. Doxorubicin induces cytotoxicity through upregulation of perk\u2013dependent ATF3. PLoS One. 2012;7(9):e44990","DOI":"10.1371\/journal.pone.0044990"},{"issue":"1","key":"1027_CR56","doi-asserted-by":"publisher","first-page":"18311","DOI":"10.1038\/s41598-024-69457-6","volume":"14","author":"P Fereydouni","year":"2024","unstructured":"Fereydouni P, Al Mohaddesin A, Khaleghi S. Targeted biocompatible Zn-metal\u2013organic framework nanocomposites for intelligent chemotherapy of breast cancer cells. Sci Rep. 2024;14(1):18311.","journal-title":"Sci Rep"}],"container-title":["BMC Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12896-025-01027-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12896-025-01027-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12896-025-01027-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T18:37:21Z","timestamp":1757443041000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbiotechnol.biomedcentral.com\/articles\/10.1186\/s12896-025-01027-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1027"],"URL":"https:\/\/doi.org\/10.1186\/s12896-025-01027-8","relation":{},"ISSN":["1472-6750"],"issn-type":[{"value":"1472-6750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]},"assertion":[{"value":"1 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of competing interest"}}],"article-number":"91"}}