{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:40:37Z","timestamp":1792640437219,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12902-015-0069-3","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T16:20:55Z","timestamp":1448554855000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of efficacy, safety, pain perception and health-related quality of life of percutaneous ethanol injection as first-line treatment in symptomatic thyroid cysts"],"prefix":"10.1186","volume":"15","author":[{"given":"Jordi L.","family":"Reverter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00eddac","family":"Mauricio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"69_CR1","unstructured":"Bryan R Haugen MD, Erik K. Alexander, Keith C. Bible, Gerard Doherty, Susan J Mandel, Yuri E. Nikiforov, Furio Pacini, Gregory Randolph, Anna Sawka, Martin Schlumberger, Kathryn G Schuff, Steven I. Sherman, Julie Ann Sosa, D Steward, R Michael Tuttle MD, Leonard Wartofsky: 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2015, 14: Epub ahead of print."},{"key":"69_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4158\/10024.GL","volume":"16","author":"H Gharib","year":"2010","unstructured":"Gharib H, Papini E, Paschke R, Duick DS, Valcavi R, Heged\u00fcs L, et al. AACE\/AME\/ETA Task Force on Thyroid Nodules. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract. 2010;16:1\u201343.","journal-title":"Endocr Pract"},{"key":"69_CR3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.mcna.2012.02.002","volume":"96","author":"G Popoveniuc","year":"2012","unstructured":"Popoveniuc G, Jonklaas J. Thyroid nodules. Med Clin North Am. 2012;96:329\u201349.","journal-title":"Med Clin North Am"},{"key":"69_CR4","doi-asserted-by":"publisher","first-page":"R133","DOI":"10.1530\/EJE-13-0917","volume":"170","author":"E Papini","year":"2014","unstructured":"Papini E, Pacella CM, Hegedus L. Diagnosis of endocrine disease: thyroid ultrasound (US) and US-assisted procedures: from the shadows into an array of applications. Eur J Endocrinol. 2014;170:R133\u201346.","journal-title":"Eur J Endocrinol"},{"key":"69_CR5","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1089\/thy.1999.9.763","volume":"9","author":"M Zingrillo","year":"1999","unstructured":"Zingrillo M, Torlontano M, Chiarella R, Ghiggi MR, Nirchio V, Bisceglia M, et al. Percutaneous ethanol injection may be a definitive treatment for symptomatic thyroid cystic nodules not treatable by surgery: five-year follow-up study. Thyroid. 1999;9:763\u20137.","journal-title":"Thyroid"},{"key":"69_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2214\/ajr.174.1.1740213","volume":"174","author":"YS Cho","year":"2000","unstructured":"Cho YS, Lee HK, Ahn IM, Lim SM, Kim DH, Choi CG, et al. Sonographically guided ethanol sclerotherapy for benign thyroid cysts: results in 22 patients. AJR Am J Roentgenol. 2000;174:213\u20136.","journal-title":"AJR Am J Roentgenol"},{"key":"69_CR7","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.1210\/jc.2003-031000","volume":"88","author":"FN Bennedbaek","year":"2003","unstructured":"Bennedbaek FN, Heged\u00fcs L. Treatment of recurrent thyroid cysts with ethanol: a randomized double-blind controlled trial. J Clin Endocrinol Metab. 2003;88:5773\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"69_CR8","first-page":"CD004098","volume":"6","author":"E Bandeira-Echtler","year":"2014","unstructured":"Bandeira-Echtler E, Bergerhoff K, Richter B. Levothyroxine or minimally invasive therapies for benign thyroid nodules. Cochrane Database Syst Rev. 2014;6:CD004098.","journal-title":"Cochrane Database Syst Rev"},{"key":"69_CR9","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1055\/s-2008-1070506","volume":"106","author":"J Brunn","year":"1981","unstructured":"Brunn J, Block U, Ruf G, Bos I, Kunze WP, Scriba PC. Volumetric analysis of thyroid lobes by realtime ultrasound [in German]. Dtsch Med Wochenschr. 1981;106:1338\u201340.","journal-title":"Dtsch Med Wochenschr"},{"key":"69_CR10","doi-asserted-by":"publisher","first-page":"234","DOI":"10.2214\/AJR.04.0816","volume":"186","author":"W Shabana","year":"2006","unstructured":"Shabana W, Peeters E, De Maeseneer M. Measuring thyroid gland volume: should we change the correction factor? AJR Am J Roentgenol. 2006;186:234\u20136.","journal-title":"AJR Am J Roentgenol"},{"key":"69_CR11","doi-asserted-by":"publisher","first-page":"687","DOI":"10.2214\/ajr.178.3.1780687","volume":"178","author":"EK Kim","year":"2002","unstructured":"Kim EK, Park CS, Chung WY, Oh KK, Kim DI, Lee JT, et al. New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. AJR Am J Roentgenol. 2002;178:687\u201391.","journal-title":"AJR Am J Roentgenol"},{"key":"69_CR12","volume-title":"SF-36 physical and mental health summary scales. A user\u2019s manual","author":"JE Ware","year":"1994","unstructured":"Ware JE, Kosinski MA, Keller SD. SF-36 physical and mental health summary scales. A user\u2019s manual. Boston: The Health Institute. New England Medical Center; 1994."},{"key":"69_CR13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4103\/0970-9371.138666","volume":"31","author":"A Muratli","year":"2014","unstructured":"Muratli A, Erdogan N, Sevim S, Unal I, Akyuz S. Diagnostic efficacy and importance of fine-needle aspiration cytology of thyroid nodules. J Cytol. 2014;31:73\u20138.","journal-title":"J Cytol"},{"key":"69_CR14","first-page":"410","volume":"111","author":"J Alonso","year":"1998","unstructured":"Alonso J, Regidor E, Gregorio B, Prieto L, Rodr\u00edguez C, De la Fuente L. Valores poblacionales de referencia de la version espa\u00f1ola del Cuestionario de Salud SF-36. Med Clin (Barc). 1998;111:410\u20136.","journal-title":"Med Clin (Barc)"},{"key":"69_CR15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/105072504322880364","volume":"14","author":"R Guglielmi","year":"2004","unstructured":"Guglielmi R, Pacella CM, Bianchini A, Bizzarri G, Rinaldi R, Graziano FM, et al. Percutaneous ethanol injection treatment in benign thyroid lesions: role and efficacy. Thyroid. 2004;14:125\u201331.","journal-title":"Thyroid"},{"key":"69_CR16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.4158\/EP.10.3.269","volume":"10","author":"R Valcavi","year":"2004","unstructured":"Valcavi R, Frasoldati A. Ultrasound-guided percutaneous ethanol injection therapy in thyroid cystic nodules. Endocr Pract. 2004;10:269\u201375.","journal-title":"Endocr Pract"},{"key":"69_CR17","first-page":"800","volume":"78","author":"F Monzani","year":"1994","unstructured":"Monzani F, Lippi F, Goletti O, Del Guerra P, Caraccio N, Lippolis PV, et al. Percutaneous aspiration and ethanol sclerotherapy for thyroid cysts. J Clin Endocrinol Metab. 1994;78:800\u20132.","journal-title":"J Clin Endocrinol Metab"},{"key":"69_CR18","first-page":"3261","volume":"81","author":"F Lippi","year":"1996","unstructured":"Lippi F, Ferrari C, Manetti L, Rago T, Santini F, Monzani F, et al. Treatment of solitary autonomous thyroid nodules by percutaneous ethanol injection: results of an Italian multicenter study. The Multicenter Study Group. J Clin Endocrinol Metab. 1996;81:3261\u20134.","journal-title":"J Clin Endocrinol Metab"},{"key":"69_CR19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1148\/radiol.13122134","volume":"269","author":"JY Sung","year":"2013","unstructured":"Sung JY, Baek JH, Kim KS, Lee D, Yoo H, Kim JK, et al. Single-session treatment of benign cystic thyroid nodules with ethanol versus radiofrequency ablation: a prospective randomized study. Radiology. 2013;269:293\u2013300.","journal-title":"Radiology"},{"key":"69_CR20","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.1210\/jc.2013-1806","volume":"98","author":"H Gharib","year":"2013","unstructured":"Gharib H, Heged\u00fcs L, Pacella CM, Baek JH, Papini E. Clinical review: Nonsurgical, image-guided, minimally invasive therapy for thyroid nodules. J Clin Endocrinol Metab. 2013;98:3949\u201357.","journal-title":"J Clin Endocrinol Metab"},{"key":"69_CR21","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nrendo.2011.1","volume":"7","author":"R Paschke","year":"2011","unstructured":"Paschke R, Hegedus L, Alexander E, Valcavi R, Papini E, Gharib H. Thyroid nodule guidelines: agreement, disagreement and need for future research. Nat Rev Endocrinol. 2011;7:354\u201361.","journal-title":"Nat Rev Endocrinol"},{"key":"69_CR22","first-page":"2111","volume":"26","author":"DW Kim","year":"2005","unstructured":"Kim DW, Rho MH, Kim HJ, Kwon JS, Sung YS, Lee SW. Percutaneous ethanol injection for benign cystic thyroid nodules: is aspiration of ethanol-mixed fluid advantageous? Am J Neuroradiol. 2005;26:2111\u201327.","journal-title":"Am J Neuroradiol"},{"key":"69_CR23","doi-asserted-by":"publisher","unstructured":"- Halenka M, Karasek D, Frysak Z: Ultrasound-guided percutaneous ethanol injection of small and medium-sized thyroid cysts with relatively small amounts of ethanol. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2014, 20: doi: 10.5507\/bp.2014.009 [Epub ahead of print].","DOI":"10.5507\/bp.2014.009"},{"key":"69_CR24","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1089\/105072502760339398","volume":"12","author":"S Prete Del","year":"2002","unstructured":"Del Prete S, Caraglia M, Russo D, Vitale G, Giuberti G, Marra M, et al. Percutaneous ethanol injection efficacy in the treatment of large symptomatic thyroid cystic nodules: ten-year follow-up of a large series. Thyroid. 2002;12:815\u201321.","journal-title":"Thyroid"},{"key":"69_CR25","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.endonu.2014.09.001","volume":"61","author":"JC Fern\u00e1ndez-Garc\u00eda","year":"2014","unstructured":"Fern\u00e1ndez-Garc\u00eda JC, Mancha-Doblas I, Tinahones FJ. Diagnostic and functional structure of a high-resolution thyroid nodule clinic: An efficiency model. Endocrinol Nutr. 2014;61:553\u20134.","journal-title":"Endocrinol Nutr"},{"key":"69_CR26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.endonu.2013.01.001","volume":"60","author":"I Arg\u00fcelles","year":"2013","unstructured":"Arg\u00fcelles I, Tof\u00e9 S. Importance of ultrasound in a department of endocrinology. Endocrinol Nutr. 2013;60:51\u20132.","journal-title":"Endocrinol Nutr"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-015-0069-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12902-015-0069-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-015-0069-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T19:02:38Z","timestamp":1475348558000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-015-0069-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["69"],"URL":"https:\/\/doi.org\/10.1186\/s12902-015-0069-3","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]},"article-number":"73"}}