{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:45:34Z","timestamp":1789152334249,"version":"build-2803163510"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12902-015-0073-7","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T22:21:23Z","timestamp":1449094883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Recombinant growth hormone therapy in children with short stature in Kuwait: a cross-sectional study of use and treatment outcomes"],"prefix":"10.1186","volume":"15","author":[{"given":"Dalia","family":"Al-Abdulrazzaq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Al-Taiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kholoud","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Al-Basari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,3]]},"reference":[{"issue":"1","key":"73_CR1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4158\/EP.9.1.64","volume":"9","author":"H Gharib","year":"2003","unstructured":"Gharib H, Cook DM, Saenger PH, Bengtsson BA, Feld S, Nippoldt TB, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in adults and children--2003 update. Endocr Pract. 2003;9(1):64\u201376.","journal-title":"Endocr Pract"},{"issue":"4","key":"73_CR2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1067\/S0022-3476(03)00246-4","volume":"143","author":"TA Wilson","year":"2003","unstructured":"Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, Brown R, et al. Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr. 2003;143(4):415\u201321.","journal-title":"J Pediatr"},{"key":"73_CR3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000316130","volume":"18","author":"E Richmond","year":"2010","unstructured":"Richmond E, Rogol AD. Current indications for growth hormone therapy for children and adolescents. Endocr Dev. 2010;18:92\u2013108.","journal-title":"Endocr Dev."},{"issue":"1","key":"73_CR4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1687-9856-2012-22","volume":"2012","author":"PA Lee","year":"2012","unstructured":"Lee PA, S\u00e4vendahl L, Oliver I, Tauber M, Blankenstein O, Ross J, et al. Comparison of response to 2-years' growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observational studies. Int J Pediatr Endocrinol. 2012;2012(1):22.","journal-title":"Int J Pediatr Endocrinol"},{"issue":"7355","key":"73_CR5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/bmj.325.7355.70","volume":"325","author":"JC Carel","year":"2002","unstructured":"Carel JC, Ecosse E, Nicolino M, Tauber M, Leger J, Cabrol S, et al. Adult height after long term treatment with recombinant growth hormone for idiopathic isolated growth hormone deficiency: observational follow up study of the French population based registry. BMJ. 2002;325(7355):70.","journal-title":"BMJ"},{"issue":"7","key":"73_CR6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1056\/NEJM199902183400702","volume":"340","author":"RL Hintz","year":"1999","unstructured":"Hintz RL, Attie KM, Baptista J, Roche A. Effect of growth hormone treatment on adult height of children with idiopathic short stature. Genentech Collaborative Group. N Engl J Med. 1999;340(7):502\u20137.","journal-title":"N Engl J Med"},{"issue":"1","key":"73_CR7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.6065\/apem.2013.18.1.13","volume":"18","author":"HK Park","year":"2013","unstructured":"Park HK, Lee HS, Ko JH, Hwang IT, Hwang JS. Response to three years of growth hormone therapy in girls with Turner syndrome. Ann Pediatr Endocrinol Metab. 2013;18(1):13\u20138.","journal-title":"Ann Pediatr Endocrinol Metab"},{"issue":"2","key":"73_CR8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3111\/13696998.2010.484323","volume":"13","author":"E Bannink","year":"2010","unstructured":"Bannink E, Djurhuus CB, Christensen T, J\u00f8ns K, Hokken-Koelega A. Adult height and health-related quality of life after growth hormone therapy in small for gestational age subjects. J Med Econ. 2010;13(2):221\u20137.","journal-title":"J Med Econ"},{"key":"73_CR9","volume":"3","author":"J Bryant","year":"2007","unstructured":"Bryant J, Djurhuus CB, Christensen T, J\u00f8ns K, Hokken-Koelega A. Recombinant growth hormone for idiopathic short stature in children and adolescents. Cochrane Database Syst Rev. 2007;3, CD004440.","journal-title":"Cochrane Database Syst Rev."},{"key":"73_CR10","unstructured":"Public Authority for Civil Information (PACI), Population Statistical Reports. 2014 [cited 2015 July 12th]; Available from: https:\/\/www.paci.gov.kw\/Home.aspx ."},{"issue":"11","key":"73_CR11","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1210\/jc.2008-0509","volume":"93","author":"P Cohen","year":"2008","unstructured":"Cohen P, Rogol AD, Deal CL, Saenger P, Reiter EO, Ross JL, et al. Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. J Clin Endocrinol Metab. 2008;93(11):4210\u20137.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6 Pt 1","key":"73_CR12","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1542\/peds.111.6.1253","volume":"111","author":"PA Lee","year":"2003","unstructured":"Lee PA, Chernausek SD, Hokken-Koelega AC, Czernichow P; International Small for Gestational Age Advisory Board. International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24-October 1, 2001. Pediatrics. 2003;111(6 Pt 1):1253\u201361.","journal-title":"Pediatrics"},{"issue":"3","key":"73_CR13","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1210\/jc.2006-2017","volume":"92","author":"PE Clayton","year":"2007","unstructured":"Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society. J Clin Endocrinol Metab. 2007;92(3):804\u201310.","journal-title":"J Clin Endocrinol Metab"},{"key":"73_CR14","first-page":"76","volume":"450","author":"Group, W.H.O.M.G.R.S.","year":"2006","unstructured":"Group, W.H.O.M.G.R.S. WHO Child Growth Standards based on length\/height, weight and age. Acta Paediatr Suppl. 2006;450:76\u201385.","journal-title":"Acta Paediatr Suppl"},{"issue":"3","key":"73_CR15","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1210\/jc.2009-1471","volume":"95","author":"MB Ranke","year":"2010","unstructured":"Ranke MB, Lindberg A, Board KI. Observed and predicted growth responses in prepubertal children with growth disorders: guidance of growth hormone treatment by empirical variables. J Clin Endocrinol Metab. 2010;95(3):1229\u201337.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"73_CR16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1210\/jc.2009-0178","volume":"95","author":"J Bell","year":"2010","unstructured":"Bell J, Parker KL, Swinford RD, Hoffman AR, Maneatis T, Lippe B. Long-term safety of recombinant human growth hormone in children. J Clin Endocrinol Metab. 2010;95(1):167\u201377.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"73_CR17","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1210\/jc.2011-1995","volume":"97","author":"JC Carel","year":"2012","unstructured":"Carel JC, Ecosse E, Landier F, Meguellati-Hakkas D, Kaguelidou F, Rey G, et al. Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study. J Clin Endocrinol Metab. 2012;97(2):416\u201325.","journal-title":"J Clin Endocrinol Metab"},{"key":"73_CR18","doi-asserted-by":"crossref","first-page":"494656","DOI":"10.1186\/1687-9856-2010-494656","volume":"2010","author":"J Ross","year":"2010","unstructured":"Ross J, Lee PA, Gut R, Germak J. Factors influencing the one- and two-year growth response in children treated with growth hormone: analysis from an observational study. Int J Pediatr Endocrinol. 2010;2010:494656.","journal-title":"Int J Pediatr Endocrinol."},{"issue":"Suppl 1","key":"73_CR19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000329161","volume":"76","author":"F Darendeliler","year":"2011","unstructured":"Darendeliler F, Lindberg A, Wilton P. Response to growth hormone treatment in isolated growth hormone deficiency versus multiple pituitary hormone deficiency. Horm Res Paediatr. 2011;76 Suppl 1:42\u20136.","journal-title":"Horm Res Paediatr"},{"issue":"7","key":"73_CR20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jfma.2011.06.011","volume":"111","author":"YH Huang","year":"2012","unstructured":"Huang YH, Wai YY, Van YH, Lo FS. Effect of growth hormone therapy on Taiwanese children with growth hormone deficiency. J Formos Med Assoc. 2012;111(7):355\u201363.","journal-title":"J Formos Med Assoc"},{"key":"73_CR21","doi-asserted-by":"crossref","first-page":"c7157","DOI":"10.1136\/bmj.c7157","volume":"342","author":"A Deodati","year":"2011","unstructured":"Deodati A, Cianfarani S. Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ. 2011;342:c7157.","journal-title":"BMJ"},{"key":"73_CR22","doi-asserted-by":"crossref","unstructured":"Grimberg A, Huerta-Saenz L, Grundmeier R, Ramos MJ, Pati S, Cucchiara AJ, et al. Gender Bias in U.S. Pediatric Growth Hormone Treatment. Sci Rep. 2015;5:11099.","DOI":"10.1038\/srep11099"},{"issue":"6","key":"73_CR23","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/jc.2007-2617","volume":"93","author":"A Grimberg","year":"2008","unstructured":"Grimberg A, Stewart E, Wajnrajch MP. Gender of pediatric recombinant human growth hormone recipients in the United States and globally. J Clin Endocrinol Metab. 2008;93(6):2050\u20136.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"73_CR24","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1210\/jc.2009-1563","volume":"95","author":"IP Hughes","year":"2010","unstructured":"Hughes IP, Choong CS, Cotterill A, Harris M, Davies PS. Gender bias in children receiving growth hormone treatment. J Clin Endocrinol Metab. 2010;95(3):1191\u20138.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"73_CR25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/cen.12677","volume":"82","author":"JS Renes","year":"2015","unstructured":"Renes JS, Willemsen RH, Mulder JC, Bakker-van Waarde WM, Rotteveel J, Oostdijk W, et al. New insights into factors influencing adult height in short SGA children: Results of a large multicentre growth hormone trial. Clin Endocrinol (Oxf). 2015;82(6):854\u201361.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"73_CR26","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1210\/jc.2005-2284","volume":"91","author":"EO Reiter","year":"2006","unstructured":"Reiter EO, Price DA, Wilton P, Albertsson-Wikland K, Ranke MB. Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database. J Clin Endocrinol Metab. 2006;91(6):2047\u201354.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"73_CR27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000098707","volume":"68","author":"MB Ranke","year":"2007","unstructured":"Ranke MB, Lindberg A, Price DA, Darendeliler F, Albertsson-Wikland K, Wilton P, et al. Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature. Horm Res. 2007;68(2):53\u201362.","journal-title":"Horm Res"},{"issue":"3","key":"73_CR28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/archpedi.156.3.230","volume":"156","author":"BS Finkelstein","year":"2002","unstructured":"Finkelstein BS, Imperiale TF, Speroff T, Marrero U, Radcliffe DJ, Cuttler L. Effect of growth hormone therapy on height in children with idiopathic short stature: a meta-analysis. Arch Pediatr Adolesc Med. 2002;156(3):230\u201340.","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"Suppl 2","key":"73_CR29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000184851","volume":"45","author":"MB Ranke","year":"1996","unstructured":"Ranke MB. Towards a consensus on the definition of idiopathic short stature. Horm Res. 1996;45 Suppl 2:64\u20136.","journal-title":"Horm Res"},{"issue":"11","key":"73_CR30","first-page":"3990","volume":"85","author":"S Growth Hormone Research","year":"2000","unstructured":"Growth Hormone Research S. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J Clin Endocrinol Metab. 2000;85(11):3990\u20133.","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"73_CR31","first-page":"1045","volume":"18","author":"SR Rose","year":"2005","unstructured":"Rose SR, Shulman DI, Larsson P, Wakley LR, Wills S, Bakker B. Gender does not influence prepubertal growth velocity during standard growth hormone therapy--analysis of United States KIGS data. J Pediatr Endocrinol Metab. 2005;18(11):1045\u201351.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"73_CR32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1687-9856-2011-6","volume":"2011","author":"PA Lee","year":"2011","unstructured":"Lee PA, Germak J, Gut R, Khutoryansky N, Ross J. Identification of factors associated with good response to growth hormone therapy in children with short stature: results from the ANSWER Program(R). Int J Pediatr Endocrinol. 2011;2011:6.","journal-title":"Int J Pediatr Endocrinol."}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-015-0073-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T20:56:07Z","timestamp":1498251367000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1472-6823\/15\/76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["73"],"URL":"https:\/\/doi.org\/10.1186\/s12902-015-0073-7","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"76"}}