{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:56:13Z","timestamp":1782215773491,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12902-016-0100-3","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T09:40:34Z","timestamp":1461404434000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A plausible role for actin gamma smooth muscle 2 (ACTG2) in small intestinal neuroendocrine tumorigenesis"],"prefix":"10.1186","volume":"16","author":[{"given":"Katarina","family":"Edfeldt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Westin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stalberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,23]]},"reference":[{"key":"100_CR1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/00001503-200306000-00017","volume":"16","author":"SF Dierdorf","year":"2003","unstructured":"Dierdorf SF. Carcinoid tumor and carcinoid syndrome. Curr Opin Anaesthesiol. 2003;16:343\u20137.","journal-title":"Curr Opin Anaesthesiol"},{"key":"100_CR2","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00268-011-1296-z","volume":"36","author":"O Norlen","year":"2012","unstructured":"Norlen O, Stalberg P, Oberg K, Eriksson J, Hedberg J, Hessman O, et al. Long-term results of surgery for small intestinal neuroendocrine tumors at a tertiary referral center. World J Surg. 2012;36:1419\u201331.","journal-title":"World J Surg"},{"key":"100_CR3","unstructured":"Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. 2010; (Ed):417."},{"key":"100_CR4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/gcc.20834","volume":"50","author":"JL Cunningham","year":"2011","unstructured":"Cunningham JL, Diaz de Stahl T, Sjoblom T, Westin G, Dumanski JP, Janson ET. Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors. Genes Chromosomes Cancer. 2011;50:82\u201394.","journal-title":"Genes Chromosomes Cancer"},{"key":"100_CR5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/gcc.20561","volume":"47","author":"MH Kulke","year":"2008","unstructured":"Kulke MH, Freed E, Chiang DY, Philips J, Zahrieh D, Glickman JN, et al. High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chromosomes Cancer. 2008;47:591\u2013603.","journal-title":"Genes Chromosomes Cancer"},{"key":"100_CR6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/ijc.1276","volume":"92","author":"RM Lollgen","year":"2001","unstructured":"Lollgen RM, Hessman O, Szabo E, Westin G, Akerstrom G. Chromosome 18 deletions are common events in classical midgut carcinoid tumors. Int J Cancer. 2001;92:812\u20135.","journal-title":"Int J Cancer"},{"key":"100_CR7","doi-asserted-by":"crossref","first-page":"2,275","DOI":"10.1530\/ERC-13-0419","volume":"21","author":"K Edfeldt","year":"2014","unstructured":"Edfeldt K, Ahmad T, Akerstrom G, Janson ET, Hellman P, Stalberg P, et al. TCEB3C a putative tumor suppressor gene of small intestinal neuroendocrine tumors. Endocr Relat Cancer. 2014;21:2,275\u2013284.","journal-title":"Endocr Relat Cancer"},{"key":"100_CR8","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1172\/JCI67963","volume":"123","author":"MS Banck","year":"2013","unstructured":"Banck MS, Kanwar R, Kulkarni AA, Boora GK, Metge F, Kipp BR, et al. The genomic landscape of small intestine neuroendocrine tumors. J Clin Invest. 2013;123:2502\u20138.","journal-title":"J Clin Invest"},{"issue":"12","key":"100_CR9","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/ng.2821","volume":"45","author":"JM Francis","year":"2013","unstructured":"Francis JM, Kiezun A, Ramos AH, Serra S, Pedamallu CS, Qian ZR, et al. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013;45(12):1483\u20136.","journal-title":"Nat Genet"},{"key":"100_CR10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1530\/ERC-10-0256","volume":"18","author":"K Edfeldt","year":"2011","unstructured":"Edfeldt K, Bjorklund P, Akerstrom G, Westin G, Hellman P, Stalberg P. Different gene expression profiles in metastasizing midgut carcinoid tumors. Endocr Relat Cancer. 2011;18:479\u201389.","journal-title":"Endocr Relat Cancer"},{"key":"100_CR11","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1175862","volume":"326","author":"TD Pollard","year":"2009","unstructured":"Pollard TD, Cooper JA. Actin, a central player in cell shape and movement. Science. 2009;326:1208\u201312.","journal-title":"Science"},{"key":"100_CR12","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1089\/cbr.2012.1431","volume":"28","author":"X Lu","year":"2009","unstructured":"Lu X, Pan J, Li S, Shen S, Chi P, Lin H, et al. Establishment of a predictive genetic model for estimating chemotherapy sensitivity of colorectal cancer with synchronous liver metastasis. Cancer Biother Radiopharm. 2009;28:552\u20138.","journal-title":"Cancer Biother Radiopharm"},{"key":"100_CR13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/02841860601156157","volume":"46","author":"MB Watson","year":"2007","unstructured":"Watson MB, Lind MJ, Smith L, Drew PJ, Cawkwell L. Expression microarray analysis reveals genes associated with in vitro resistance to cisplatin in a cell line model. Acta Oncology. 2007;46:651\u20138.","journal-title":"Acta Oncology"},{"key":"100_CR14","first-page":"1351","volume":"6","author":"CZ Xu","year":"2013","unstructured":"Xu CZ, Xie J, Jin B, Chen XW, Sun ZF, Wang BX, et al. Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. Int J Clin Exp Pathol. 2013;6:1351\u201361.","journal-title":"Int J Clin Exp Pathol"},{"issue":"11","key":"100_CR15","doi-asserted-by":"crossref","first-page":"e113071","DOI":"10.1371\/journal.pone.0113071","volume":"9","author":"JE Drew","year":"2014","unstructured":"Drew JE, Farquharson AJ, Mayer CD, Vase HF, Coates PJ, Steele RJ, et al. Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma. PLoS One. 2014;9(11):e113071.","journal-title":"PLoS One"},{"key":"100_CR16","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/onc.2009.381","volume":"29","author":"AH Beck","year":"2010","unstructured":"Beck AH, Lee CH, Witten DM, Gleason BC, Edris B, Espinosa I, et al. Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. Oncogene. 2010;29:845\u201354.","journal-title":"Oncogene"},{"issue":"8","key":"100_CR17","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1038\/bjc.2013.549","volume":"109","author":"SU Lauvrak","year":"2013","unstructured":"Lauvrak SU, Munthe E, Kresse SH, Stratford EW, Namlos HM, Meza-Zepeda LA, et al. Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes. Br J Cancer. 2013;109(8):2228\u201336.","journal-title":"Br J Cancer"},{"key":"100_CR18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.biopha.2012.04.001","volume":"66","author":"ZY Lin","year":"2012","unstructured":"Lin ZY, Chuang WL. Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells. Biomed Pharmacother. 2012;66:454\u20138.","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"100_CR19","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.fertnstert.2012.11.055","volume":"99","author":"M Adammek","year":"2013","unstructured":"Adammek M, Greve B, Kassens N, Schneider C, Bruggmann K, Schuring AN, et al. MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors. Fertil Steril. 2013;99(5):1346\u201355.","journal-title":"Fertil Steril"},{"key":"100_CR20","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1038\/onc.2010.386","volume":"29","author":"M Gotte","year":"2010","unstructured":"Gotte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M. miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. Oncogene. 2010;29:6569\u201380.","journal-title":"Oncogene"},{"key":"100_CR21","first-page":"845","volume":"16","author":"Y Akao","year":"2006","unstructured":"Akao Y, Nakagawa Y, Naoe T. MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers. Oncol Rep. 2006;16:845\u201350.","journal-title":"Oncol Rep"},{"key":"100_CR22","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1158\/1078-0432.CCR-06-2723","volume":"13","author":"G Buren Van 2nd","year":"2007","unstructured":"Van Buren 2nd G, Rashid A, Yang AD, Abdalla EK, Gray MJ, Liu W, et al. The development and characterization of a human midgut carcinoid cell line. Clin Cancer Res. 2007;13:4704\u201312.","journal-title":"Clin Cancer Res"},{"key":"100_CR23","volume":"7","author":"SC Li","year":"2012","unstructured":"Li SC, Martijn C, Cui T, Essaghir A, Luque RM, Demoulin JB, et al. The somatostatin analogue octreotide inhibits growth of small intestinal neuroendocrine tumour cells. PLoS One. 2012;7, e48411.","journal-title":"PLoS One"},{"key":"100_CR24","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1158\/1078-0432.CCR-10-2550","volume":"16","author":"LM Ellis","year":"2010","unstructured":"Ellis LM, Samuel S, Sceusi E. Varying opinoins on the authenticity of a human midgut carcinoid cell line - letter. Clin Cancer Res. 2010;16:5365\u20136.","journal-title":"Clin Cancer Res"},{"key":"100_CR25","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1210\/jc.2006-1197","volume":"92","author":"P Bj\u00f6rklund","year":"2007","unstructured":"Bj\u00f6rklund P, \u00c5kerstr\u00f6m G, Westin G. Accumulation of nonphosphorylated \u00df-catenin and c-myc in primary and uremic secondary hyperparathyroid tumors. J Clin Endocrinol Metab. 2007;92:338\u201344.","journal-title":"J Clin Endocrinol Metab"},{"key":"100_CR26","first-page":"2967","volume":"87","author":"U Segersten","year":"2002","unstructured":"Segersten U, Correa P, Hewison M, Hellman P, Dralle H, Carling T, \u00c5kerstr\u00f6m G, Westin G. 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands. J Clin Endocrinol Metab. 2002;87:2967\u201372.","journal-title":"J Clin Endocrinol Metab"},{"key":"100_CR27","doi-asserted-by":"crossref","first-page":"E1307","DOI":"10.1210\/jc.2011-3136","volume":"97","author":"J Svedlund","year":"2012","unstructured":"Svedlund J, Koskinen Edblom S, Marquez VE, \u00c5kerstr\u00f6m G, Bj\u00f6rklund P, Westin G. Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modification. J Clin Endocrinol Metab. 2012;97:E1307\u201315.","journal-title":"J Clin Endocrinol Metab"},{"key":"100_CR28","doi-asserted-by":"crossref","first-page":"7922","DOI":"10.1073\/pnas.1303800110","volume":"110","author":"SK Knutson","year":"2013","unstructured":"Knutson SK, Warholic NM, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A. 2013;110:7922\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"100_CR29","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1158\/1535-7163.MCT-09-0013","volume":"8","author":"TB Miranda","year":"2009","unstructured":"Miranda TB, Cortez CC, Yoo CB, Liang G, Abe M, Kelly TK. DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther. 2009;8:1579\u201388.","journal-title":"Mol Cancer Ther"},{"key":"100_CR30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature09784","volume":"469","author":"R Margueron","year":"2011","unstructured":"Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature. 2011;469:343\u20139.","journal-title":"Nature"},{"key":"100_CR31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/dna.2006.0550","volume":"26","author":"Y Akao","year":"2007","unstructured":"Akao Y, Nakagawa Y, Naoe T. MicroRNA-143 and \u2212145 in colon cancer. DNA Cell Biol. 2007;26:311\u201320.","journal-title":"DNA Cell Biol"},{"key":"100_CR32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1517\/14712598.2011.542749","volume":"11","author":"H Tazawa","year":"2011","unstructured":"Tazawa H, Kagawa S, Fujiwara T. MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors. Expert Opin Biol Ther. 2011;11:145\u201355.","journal-title":"Expert Opin Biol Ther"},{"key":"100_CR33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1254\/jphs.10R12FM","volume":"114","author":"Y Kitade","year":"2010","unstructured":"Kitade Y, Akao Y. MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and \u2212145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug. J Pharmacol Sci. 2010;114:276\u201380.","journal-title":"J Pharmacol Sci"},{"key":"100_CR34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/modpathol.2009.161","volume":"23","author":"K Ruebel","year":"2010","unstructured":"Ruebel K, Leontovich A, Stilling G, Zhang S, Righi A, Jin L, et al. MicroRNA expression in ileal carcinoid tumors: downregulation of microRNA-133a with tumor progression. Mod Pathol. 2010;23:367\u201375.","journal-title":"Mod Pathol"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-016-0100-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T11:37:32Z","timestamp":1498304252000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-016-0100-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,23]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["100"],"URL":"https:\/\/doi.org\/10.1186\/s12902-016-0100-3","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,23]]},"article-number":"19"}}