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This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria. Subjects were randomly assigned into two groups to take either synbiotic (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) for 12\u00a0weeks. Endocrine, inflammation and oxidative stress biomarkers were quantified at baseline and after the 12-week intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After the 12-week intervention, compared with the placebo, synbiotic supplementation significantly increased serum sex hormone-binding globulin (SHBG) (changes from baseline in synbiotic group: +\u200919.8\u2009\u00b1\u200947.3 vs. in placebo group: +\u20090.5\u2009\u00b1\u20095.4\u00a0nmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), plasma nitric oxide (NO) (changes from baseline in synbiotic group: +\u20095.5\u2009\u00b1\u20094.8 vs. in placebo group: +\u20090.3\u2009\u00b1\u20099.1\u00a0\u03bcmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), and decreased modified Ferriman Gallwey (mF-G) scores (changes from baseline in synbiotic group: \u2212\u20091.3\u2009\u00b1\u20092.5 vs. in placebo group: \u2212\u20090.1\u2009\u00b1\u20090.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and serum high-sensitivity C-reactive protein (hs-CRP) (changes from baseline in synbiotic group: \u2212\u2009950.0\u2009\u00b1\u20092246.6 vs. in placebo group: +\u2009335.3\u2009\u00b1\u20092466.9\u00a0ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). We did not observe any significant effect of synbiotic supplementation on other hormonal status and biomarkers of oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, synbiotic supplementation for 12\u00a0weeks in PCOS women had beneficial effects on SHBG, mFG scores, hs-CRP and NO levels, but did not affect other hormonal status and biomarkers of oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      This study was retrospectively registered in the Iranian website (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.irct.ir\">www.irct.ir<\/jats:ext-link>\n                      ) for registration of clinical trials (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.irct.ir\">IRCT201509115623N53<\/jats:ext-link>\n                      ), on 2015\u201309-27.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-018-0248-0","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T09:24:35Z","timestamp":1523525075000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial"],"prefix":"10.1186","volume":"18","author":[{"given":"Khadijeh","family":"Nasri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehri","family":"Jamilian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Rahmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Bahmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Tajabadi-Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zatollah","family":"Asemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,12]]},"reference":[{"key":"248_CR1","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1177\/1933719114522525","volume":"21","author":"NM Clark","year":"2014","unstructured":"Clark NM, Podolski AJ, Brooks ED, et al. 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There is also an ongoing investigation by the Iranian National Committee for Ethics in Biomedical Researches. Further editorial action will be taken as appropriate once the investigation into the concerns is complete and all parties have been given an opportunity to respond in full.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted according to the ethical guidelines of the Declaration of Helsinki (the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments) and was approved by the ethics committee of the Arak University of Medical Sciences (AUMS), Arak, Iran (\n                      \n                      : IRCT201509115623N53). 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