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Fetal biometry including abdominal circumference (AC), estimated fetal weight (EFW), and adiposity measurements (mid-thigh fat mass, subscapular fat mass, abdominal fat mass) were obtained from ultrasound assessments at 28 and 36\u2009weeks\u2019 gestation. Maternal markers included C reactive protein (CRP), leptin and adiponectin concentrations, measured at 28 and 36\u2009weeks\u2019 gestation and fasting triglycerides and glucose concentrations measured at 28\u2009weeks\u2019 gestation.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were negative associations identified between maternal serum adiponectin and fetal ultrasound markers of biometry and adiposity. After adjusting for confounders, a 1-unit increase in log Adiponectin was associated with a reduction in the mean AC z score [\u2212\u20090.21 (\u2212\u20090.35, \u2212\u20090.07), <jats:italic>P<\/jats:italic>\u2009=\u20090.004] and EFW [\u2212\u20090.23 (\u2212\u20090.37, \u2212\u20090.10), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001] at 28\u2009weeks gestation. Similarly, a 1-unit increase in log Adiponectin was association with a reduction in the mean AC z score [\u2212\u20090.30 (\u2212\u20090.46, \u2212\u20090.13), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001] and EFW [\u2212\u20090.24 (\u2212\u20090.38, \u2212\u20090.10), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001] at 36\u2009weeks gestation. There were no consistent associations between maternal cardiometabolic and inflammatory markers with measurements of fetal adiposity.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Adiponectin concentrations are associated with measures of fetal growth. Our findings contribute to further understanding of fetal growth in the setting of women who are overweight or obesity.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-019-0416-x","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T10:14:39Z","timestamp":1570702479000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal cardiometabolic markers are associated with fetal growth: a secondary exploratory analysis of the LIMIT randomised trial"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-7197","authenticated-orcid":false,"given":"Cecelia M.","family":"O\u2019Brien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennie","family":"Louise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Deussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie M.","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"416_CR1","volume-title":"Pregnancy outcome in South Australia 2014","author":"W Scheil","year":"2016","unstructured":"Scheil W, Jolly K, Scott J, Catcheside B, Sage L, Kennare R. 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The ethics approval study number for LIMIT randomised controlled trial was 1839\/6 (approved July 2006) and for the fetal growth ancillary study number was 2051\/4 (approved April 2008).Each collaborating site obtained their individual ethics approval for the LIMIT randomised controlled trial including The Women\u2019s and Children\u2019s Health Network (WCHN) Human Research Ethics Committee\u2019s (application REC 1839\/6\/2012); Ethics of Human Research Committee, The Queen Elizabeth Hospital and Lyell McEwin Hospital (application 2,008,033); and Flinders Clinical Research Ethics Committee, Flinders Medical Centre (Application 128\/08). The fetal growth ancillary study was approved in April 2008 by the The Women\u2019s and Children\u2019s Health Network (WCHN) Human Research Ethics Committee\u2019s (HREC) (application 2051\/4).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"97"}}