{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:02:11Z","timestamp":1786723331446,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To investigate the prevalence of cardiovascular disease (CVD) risk factors and assess the 10-year risk of CVD in non-menopausal and postmenopausal women with type 2 diabetes mellitus (T2DM).<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 569 patients with T2DM at a Chinese tertiary hospital were investigated using the Framingham Risk Score (FRS). We evaluated the 10-year risk of CVD, clinical and menopause characteristics in all subjects.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among the 569 diabetic patients, the incidence of smoking, dyslipidemia, hypertension, overweight or obesity, and nonalcoholic fatty liver disease (NAFLD) was 0.7, 36.2, 38.1 56.6 and 58.2%, respectively. The usage rate of hypoglycemic agents, antihypertensive agents, lipid modulators and antithrombotic drugs was 88.6, 78.3, 50.0 and 27.1%, respectively. However, only 1.2% of inpatients achieved the three target goals for the control of blood glucose (HbA<jats:sub>1c<\/jats:sub>\u2009&lt;\u20097%), blood pressure (systolic blood pressure\u2009&lt;\u2009130\u2009mmHg, diastolic blood pressure\u2009&lt;\u200980\u2009mmHg), and blood lipids (total cholesterol &lt;\u2009174\u2009mg\/dL). The 10-year risk of CVD was (1.6\u2009\u00b1\u20091.5%) and tended to increase along with age (<jats:italic>F<\/jats:italic>\u2009=\u200927.726, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001). For all subjects (<jats:italic>n<\/jats:italic>\u2009=\u2009569), multiple linear regression analysis showed that menopause (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.275, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001), low-density lipoprotein cholesterol (LDL-C) (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.212, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001), fasting plasma glucose (FPG) (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.093, <jats:italic>P<\/jats:italic>\u2009=\u20090.018) and waist-to-hip-ratio (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212\u20090.078, <jats:italic>P<\/jats:italic>\u2009=\u20090.047) were risk factors of 10-year risk of CVD, which may explain the variance of 14.3%. In the postmenopausal group (<jats:italic>n<\/jats:italic>\u2009=\u2009397), LDL-C (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.227, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001), FPG (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.139, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) and time since menopause (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.230, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001) were found to be associated with CVD, which may explain the variance of 14.6%.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The incidence of dyslipidmia, hypertension, overweight or obesity and NAFLD is high. The level of control of blood glucose, blood pressure, and blood lipids was found to be extremely low and the treatment status was not ideal. Besides menopause, LDL-C, FPG and time since menopause were found to be independent risk factors for the 10-year risk of CVD. Therefore, it is necessary to focus on comprehensive control of multiple risk factors, such as plasma glucose, blood pressure and serum lipid.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-019-0427-7","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T02:02:26Z","timestamp":1570759346000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prevalence of cardiovascular risk factors in non-menopausal and postmenopausal inpatients with type 2 diabetes mellitus in China"],"prefix":"10.1186","volume":"19","author":[{"given":"Huanhuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-8540","authenticated-orcid":false,"given":"Xiaoyun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"427_CR1","doi-asserted-by":"crossref","unstructured":"Yang L, Lin L, Kartsonaki C, Guo Y, Chen Y, Bian Z, Xie K, Jin D, Li L, Lv J, Chen Z; China Kadoorie Biobank Study Collaborative Group. 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Hum Reprod. 2000;15:599\u2013603.","journal-title":"Hum Reprod"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-019-0427-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12902-019-0427-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-019-0427-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T23:09:53Z","timestamp":1602284993000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-019-0427-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["427"],"URL":"https:\/\/doi.org\/10.1186\/s12902-019-0427-7","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,11]]},"assertion":[{"value":"29 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Board Committee of The First people\u2019s Hospital of Changzhou. The personal information and medical records of each patient were strictly protected. When the patients were admitted to the hospital, the doctor signed a treatment consent form with them and asked if they agreed to participate in our study. The signed documents were kept with the documentation of each patient. When they were discharged from hospital, the cases were filed, resulting in written consent not needed again. However, verbal informed consent was obtained from all participants in our study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"98"}}