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However, there have been few studies conducted on Chinese people. Thus, we aimed to verify the usefulness of the glucose response curve in a large Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 9059 OGTT (3-h tests) were categorized into either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, the Matsuda Index, the insulinogenic index, and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The shape of the OGTT glucose response curve was monophasic in 87.3% and multiphasic in 12.7% of participants. Individuals in the multiphasic group were younger compared to those in the monophasic group (38.6\u2009\u00b1\u200913.6 vs. 35.4\u2009\u00b1\u200913.5,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Individuals in the monophasic group had significantly higher fasting plasma glucose (FPG 5.6\u2009\u00b1\u200913.5 vs. 5.2\u2009\u00b1\u20090.6,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), fasting insulin (FINS 14.8\u2009\u00b1\u20098.7 vs. 13.5\u2009\u00b1\u20097.9,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), and homeostasis model assessment of insulin resistance (HOMA-IR 3.8\u2009\u00b1\u20092.6 vs. 3.1\u2009\u00b1\u20092.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and impaired \u03b2-cell function (disposition index 12.7\u2009\u00b1\u200914.1 vs. 16.6\u2009\u00b1\u200917.8,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to those in the multiphasic group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The monophasic OGTT glucose response curve could reflect impaired \u03b2-cell function in a large Chinese population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-019-0446-4","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T12:03:46Z","timestamp":1572955426000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The shape of the glucose response curve during an oral glucose tolerance test heralds \u03b2\u2013cell function in a large Chinese population"],"prefix":"10.1186","volume":"19","author":[{"given":"Xinqi","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-7584","authenticated-orcid":false,"given":"Huabing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"446_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12929-016-0303-y","volume":"23","author":"K Rehman","year":"2016","unstructured":"Rehman K, Akash MS. 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The study protocol was approved by the Ethics Committee of Peking Union Medical College Hospital. The permission to access the raw data was granted by the Ethics Committee of Peking Union Medical College Hospital.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"119"}}