{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T01:01:39Z","timestamp":1780794099989,"version":"3.54.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670717"],"award-info":[{"award-number":["81670717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Primary hyperparathyroidism is characterized by hypercalcemia and elevated or inappropriately normal serum levels of parathyroid hormone. Brown tumor of bone is a rare non-neoplastic lesion resulted from abnormal bone metabolism in hyperparathyroidism. However, nowadays, skeletal disease caused by primary hyperparathyroidism is uncommon. We report a case of brown tumor in the mandible as the initial exhibition of primary hyperparathyroidism associated with an atypical parathyroid adenoma.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>The patient was a 49-year-old female, she had a pain mass on the right mandible a year ago and was treated with root canal therapy and marginal resection. After seven months, the mass recurred and enlarged. Enhanced CT scan, laboratory examination, Ultrasonography, <jats:sup>99m<\/jats:sup>Tc-MIBI SPECT-CT scintiscan and pathological examination were used to confirm the diagnosis of brown tumor. The patient\u2019s symptom improved after parathyroidectomy.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p><jats:sup>99m<\/jats:sup>Tc-MIBI SPECT\/CT scintigraphy is a highly sensitive examination of the localization diagnosis of hyperparathyroidism. Brown tumors should be considered in the differential diagnosis of osteolytic lesions to avoid unnecessary and harmful interventions.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12902-019-0480-2","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T12:03:04Z","timestamp":1578916984000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Primary hyperparathyroidism presenting as a brown tumor in the mandible: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Bojin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1763-0394","authenticated-orcid":false,"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"480_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrendo.2017.104","volume":"14","author":"MD Walker","year":"2018","unstructured":"Walker MD, Silverberg SJ. Primary hyperparathyroidism. Nat Rev Endocrinol. 2018;14:115\u201325.","journal-title":"Nat Rev Endocrinol"},{"key":"480_CR2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S0140-6736(17)31430-7","volume":"391","author":"JP Bilezikian","year":"2018","unstructured":"Bilezikian JP, Bandeira L, Khan A, Cusano NE. Hyperparathyroidism. Lancet. 2018;391:168\u201378.","journal-title":"Lancet"},{"key":"480_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/dc.23631","volume":"45","author":"M Agnihotri","year":"2017","unstructured":"Agnihotri M, Kothari K, Naik L. Brown tumor of hyperparathyroidism. Diagn Cytopathol. 2017;45:43\u20134.","journal-title":"Diagn Cytopathol"},{"key":"480_CR4","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.joms.2004.02.011","volume":"62","author":"MM Suarez-Cunqueiro","year":"2004","unstructured":"Suarez-Cunqueiro MM, Schoen R, Kersten A, Klisch J, Schmelzeisen R. Brown tumor of the mandible as first manifestation of atypical parathyroid adenoma. J Oral Maxillofac Surg. 2004;62:1024\u20138.","journal-title":"J Oral Maxillofac Surg"},{"key":"480_CR5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0385-8146(01)00099-2","volume":"28","author":"E Guney","year":"2001","unstructured":"Guney E, Yigitbasi OG, Bayram F, Ozer V, Canoz O. Brown tumor of the maxilla associated with primary hyperparathyroidism. Auris Nasus Larynx. 2001;28:369\u201372.","journal-title":"Auris Nasus Larynx"},{"issue":"2","key":"480_CR6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1210\/jc.2012-2914","volume":"98","author":"L Zhao","year":"2013","unstructured":"Zhao L, Liu JM, He XY, Zhao HY, Sun LH, Tao B, Zhang MJ, Chen X, Wang WQ, Ning G. The changing clinical patterns of primary hyperparathyroidism in Chinese patients: data from 2000 to 2010 in a single clinical center. J Clin Endocrinol Metab. 2013;98(2):721\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"480_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1259\/dmfr\/81694583","volume":"38","author":"F Selvi","year":"2009","unstructured":"Selvi F, Cakarer S, Tanakol R, Guler SD, Keskin C. Brown tumour of the maxilla and mandible: a rare complication of tertiary. Dentomaxillofac Radiol. 2009;38:53\u20138.","journal-title":"Dentomaxillofac Radiol"},{"key":"480_CR8","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1159\/000325556","volume":"52","author":"AM Kemp","year":"2008","unstructured":"Kemp AM, Bukvic M, Sturgis CD. Fine needle aspiration diagnosis of osteitis fifibrosa cystica (Brown tumor of bone): a case report. 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