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Thyrotropin receptor antibodies (TRAb) and\/or thyroid-stimulating antibody (TSAb) are usually used for diagnosis of Basedow\u2019s disease, and thyroid peroxidase antibodies (TPOAb) and\/or thyroglobulin antibodies (TgAb) are for diagnosis of Hashimoto\u2019s thyroiditis. However, it is difficult to diagnose a subject as Basedow\u2019s disease with associated features of Hashimoto\u2019s thyroiditis only with elevation of such autoimmune antibodies.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 44-year-old woman with 5-year history of Basedow\u2019s disease underwent a total thyroidectomy. She did not have a goiter. TRAb, TSAb, TPOAg and TgAb were all positive before a total thyroidectomy. In histopathological macroscopic examination, diffuse hyperplasia of the thyroid gland was observed. Furthermore, in histopathological microscopic examination, both characteristics of Basedow\u2019s disease and Hashimoto\u2019s thyroiditis were observed. After a total thyroidectomy, titers of all thyroid-associated autoimmune antibodies were markedly reduced.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Herein, we report a subject with Basedow\u2019s disease without a goiter whose TPOAb and TgAb were relatively high at the onset of Basedow\u2019s disease. In addition, interestingly, the histopathological findings of this subject showed direct signs of Basedow\u2019s disease and Hashimoto\u2019s thyroiditis in the same thyroid gland. Considering from such findings, she seemed to have Basedow\u2019s disease with associated features of Hashimoto\u2019s thyroiditis. In conclusion, we should bear in mind the possibility of Basedow\u2019s disease with associated features of Hashimoto\u2019s thyroiditis in subjects with Basedow\u2019s disease, particularly when TPOAb and TgAb as well as TRAb and TSAb are positive.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12902-020-00602-8","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T11:02:58Z","timestamp":1596625378000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Basedow\u2019s disease with associated features of Hashimoto\u2019s thyroiditis based on histopathological findings"],"prefix":"10.1186","volume":"20","author":[{"given":"Megumi","family":"Horiya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7862-3385","authenticated-orcid":false,"given":"Takatoshi","family":"Anno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Irie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Monobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tomoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Kaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Kaneto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"602_CR1","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/BF03350031","volume":"12","author":"A Gauna","year":"1989","unstructured":"Gauna A, Segura G, Sartorio G, Soto R, Segal-Eiras A. 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