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Type 2 diabetes patients aged &gt;\u200955\u2009years were recruited and assigned into three groups based on their glycated hemoglobin (HbA1c) levels: HbA1c &lt;\u20097, 7%\u2009\u2264\u2009HbA1c\u2009&lt;\u20098% and HbA1c \u22658%. MMSE decline was considered the endpoint. Factors related to MMSE decline were identified by univariate and multivariate regression analyses.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Altogether, 1519 subjects were included, 883 in the Low group, 333 in the Median group, and 303 in the High group. Age\u2009\u2265\u200975\u2009years, education below elementary school level, not participating in seminars or consultation on healthcare, physical activity less than 30\u2009min\/day, cerebrovascular disease history, MMSE score at baseline, and HBA1c \u22658% were associated with cognitive decline by univariate and multivariate analysis. When the other factors were adjusted for, HBA1c \u22658% was independently associated with the severity of cognitive decline (\u03b2\u2009=\u20090.58, 95%CI:0.06\u20131.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.029) and the occurrence of cognitive decline (odds ratio (OR)\u2009=\u20091.55, 95%CI:1.13\u20132.12, <jats:italic>P<\/jats:italic>\u2009=\u20090.007).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In elderly patients with type 2 diabetes, HbA1c \u22658% is an independent factor for cognitive decline and is also associated with the severity of the cognitive decline.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12902-020-00606-4","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T12:02:43Z","timestamp":1598356963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk of mini-mental state examination (MMSE) decline in the elderly with type 2 diabetes: a Chinese community-based cohort study"],"prefix":"10.1186","volume":"20","author":[{"given":"Lei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang Ling","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piu","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"606_CR1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nrendo.2011.183","volume":"8","author":"L Chen","year":"2011","unstructured":"Chen L, Magliano DJ, Zimmet PZ. 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Written informed consent was obtained from all participants for the original data collection.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}