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This study evaluates the interplay of various metabolic factors with occurrence of deranged thyroid function tests in children suffering from DKA\/DK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      98 DKA and 96 DK pediatric patients were selected from hospital records. Those on thyroxine replacement, with overt hypothyroidism, or with positive anti-thyroperoxidase (TPO) antibody were excluded. Tests for liver function, renal function, lipid profile, serum osmolarity, thyroid function, c-peptide levels, and glycosylated hemoglobin were done on all patients. Children were divided into euthyroid (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200988) and ESS groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ESS group had a higher level of white blood cell count (WBC), plasma glucose (PG), beta-hydroxybutyric acid (\u03b2-HB), triglyceride (TG), anion gap (AG), glycosylated hemoglobin (HbA1c) and a lower level of HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      , prealbumin (PA), and albumin (ALB) compared with the euthyroid group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Free T3 (FT3) levels were significantly correlated to \u03b2-HB, HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      , AG, PA, and HbA1c (r\u2009=\u2009\u2212\u20090.642, 0.681, \u2212\u20090.377, 0.581, \u2212\u20090.309, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Free T4 (FT4) levels were significantly correlated to \u03b2-HB, HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      , and ALB levels (r\u2009=\u2009\u2212\u20090.489, 0.338, 0.529, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). TSH levels were significantly affected by HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      only (r\u2009=\u2009\u2212\u20090.28; P\u2009&lt;\u20090.01). HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      level was the most important factor deciding euthyroid or ESS on logistic regression analysis (OR\u2009=\u20090.844,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004, 95%CI\u2009=\u20090.751\u20130.948).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower levels of free thyroid hormones and occurrence of ESS were associated with a higher degree of acidosis in children with DKA\/DK.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-020-00616-2","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T11:03:51Z","timestamp":1598958231000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Determinants of deranged thyroid function parameters in children admitted for management of diabetic ketoacidosis\/diabetic ketosis"],"prefix":"10.1186","volume":"20","author":[{"given":"Peng","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-4555","authenticated-orcid":false,"given":"Guimei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daogang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"616_CR1","doi-asserted-by":"publisher","first-page":"j5295","DOI":"10.1136\/bmj.j5295","volume":"360","author":"J Weng","year":"2018","unstructured":"Weng J, Zhou Z, Guo L, Zhu D, Ji L, Luo X, Mu Y, Jia W. 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