{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:59:13Z","timestamp":1777111153191,"version":"3.51.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Gynaecomastia is a fairly common condition in puberty but is rare in prepubertal boys. While it is necessary to exclude possible endocrinopathay in prepubertal gynaecomastia, medication is an important and potentially reversible cause to consider in new onset gynaecomastia. Isoniazid-induced gynaecomastia has been reported in adult males, but none was reported in the paediatric population and general paediatricians may not be aware of this uncommon side effect.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We hereby report a 11-year-old prepubertal boy who developed gynaecomastia while taking anti-tuberculosis drugs. Investigations excluded endocrinopathies. Gynaecomastia subsided 8\u2009weeks after stopping isoniazid.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This case is the first paediatric case report describing the association of gynaecomastia with isoniazid use. It is important for general paediatricians to recognize this entity, as prompt diagnosis and cessation of the offending drug can lead to resolution of the problem.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-020-00639-9","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T12:05:57Z","timestamp":1603800357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Isoniazid-induced gynaecomastia: report of a paediatric case and review of literature"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-9699","authenticated-orcid":false,"given":"Sarah Wing Yiu","family":"Poon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Ka","family":"Siu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita Man Ching","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"issue":"5","key":"639_CR1","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1111\/j.1365-2958.2006.05467.x","volume":"62","author":"GS Timmins","year":"2006","unstructured":"Timmins GS, Deretic V. Mechanisms of action of isoniazid. Mol Microbiol. 2006;62(5):1220\u20137.","journal-title":"Mol Microbiol"},{"key":"639_CR2","first-page":"5","volume":"12","author":"SSF Leung","year":"1995","unstructured":"Leung SSF, Tse LY, Wong GWK, et al. Standards for the anthropometric assessment of nutritional status of Hong Kong children. HKJ Paediatr. 1995;12:5\u201315.","journal-title":"HKJ Paediatr"},{"issue":"11","key":"639_CR3","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nrendo.2014.139","volume":"10","author":"HS Narula","year":"2014","unstructured":"Narula HS, Carlson HE. Gynaecomastia\u2014pathophysiology, diagnosis and treatment. Nat Rev Endocrinol. 2014;10(11):684\u201398.","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"639_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1056\/NEJMoa064725","volume":"356","author":"DV Henley","year":"2007","unstructured":"Henley DV, Lipson N, Korach KS, Bloch CA. 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A copy can be made available upon request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"160"}}