{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:02:57Z","timestamp":1793772177871,"version":"4.6.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Microalbuminuria is a prognostic marker of diabetes kidney disease. It is generally diagnosed as the ratio of urinary albumin to creatinine (UACR) of 30-300\u2009mg\/g. Hashimoto\u2019s thyroiditis is a common disease in the endocrinology and the thyroid antibodies may associated with kidney disease. We investigated the UACR in the newly diagnosed T2DM with Hashimoto\u2019s thyroiditis and tried to detect the relationship between the UACR and thyroid antibodies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>One hundred twenty newly diagnosed T2DM patients with Hashimoto\u2019s thyroiditis and euthyroidism and 50 sex and age-matched T2DM with non-Hashimoto\u2019s and other thyroid disease were recruited. T2DM patients were divided into 2 groups by the titer of TPOAb: (1). TPOAb (+) group: T2DM with positive TPOAb (<jats:italic>n<\/jats:italic>\u2009=\u2009105); (2). TPOAb (\u2212) group: T2DM with negative TPOAb (<jats:italic>n<\/jats:italic>\u2009=\u200965).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>T2DM with positive TPOAb group had higher UACR than T2DM with negative TPOAb group (21.55\u2009\u00b1\u20097.28 vs 15.13\u2009\u00b1\u20095.69\u2009mg\/g, <jats:italic>P\u2009&lt;\u20090.01<\/jats:italic>). UACR were positively related to BMI (<jats:italic>r<\/jats:italic>\u2009=\u20090.255, <jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>), FPG (<jats:italic>r<\/jats:italic>\u2009=\u20090.285, <jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>), HbA1c (<jats:italic>r<\/jats:italic>\u2009=\u20090.260, <jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>) and TPOAb (<jats:italic>r<\/jats:italic>\u2009=\u20090.349, <jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>). HbA1c (\u03b2\u2009=\u20090.793, <jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>), BMI (\u03b2\u2009=\u20090.342, <jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>) and lnTPOAb (\u03b2\u2009=\u20091.207, <jats:italic>P\u2009&lt;\u20090.05<\/jats:italic>) were independently associated with UACR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In the newly diagnosed T2DM patients, Hashimoto\u2019s thyroiditis with TPOAb positive had higher UACR levels. TPOAb titer, BMI and HbA1c were independent associated with UACR in these patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-020-00650-0","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T20:03:53Z","timestamp":1606161833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The association between albuminuria and thyroid antibodies in newly diagnosed type 2 diabetes mellitus patients with Hashimoto\u2019s thyroiditis and euthyroidism"],"prefix":"10.1186","volume":"20","author":[{"given":"Wei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejie","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-6300","authenticated-orcid":false,"given":"Guang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"issue":"24","key":"650_CR1","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1001\/jama.2017.7596","volume":"317","author":"L Wang","year":"2017","unstructured":"Wang L, Gao P, Zhang M, et al. 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All procedures were conducted in accordance with Declaration of Helsinki. The ethics committee of Beijing Chao-yang Hospital approved the present research.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"172"}}