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We aimed to clinically characterize patients with PASCS who are poorly profiled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population-based, retrospective, single-center, observational study was conducted in 71 patients (age, 58.2\u2009\u00b1\u200911.2\u2009years; 24 males and 47 females) who developed PA (<jats:italic>n<\/jats:italic>\u2009=\u200945), SCS (<jats:italic>n<\/jats:italic>\u2009=\u200912), or PASCS (<jats:italic>n<\/jats:italic>\u2009=\u200914). The main outcome measures were the proportion of patients with diabetes mellitus (DM), serum potassium concentration, and maximum tumor diameter (MTD) on the computed tomography (CT) scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of DM patients was significantly greater in the PASCS group than in the PA group (50.0% vs. 13.9%,<jats:italic>p<\/jats:italic>\u2009&lt;\u2009\u00a00.05), without a significant difference between the PASCS and SCS groups. Serum potassium concentration was significantly lower in the PASCS group than in the SCS group (3.2\u2009\u00b1\u20090.8\u2009mEq\/L vs. 4.0\u2009\u00b1\u20090.5\u2009mEq\/L;<jats:italic>p<\/jats:italic>\u2009&lt;\u2009\u00a00.01), without a significant difference between the PASCS and PA groups. Among the 3 study groups of patients who had a unilateral adrenal tumor, MTD was significantly greater in the PASCS group than in the PA group (2.7\u2009\u00b1\u20090.1\u2009cm vs. 1.4\u2009\u00b1\u20090.1\u2009cm;<jats:italic>p<\/jats:italic>\u2009&lt;\u2009\u00a00.001), without a significant difference between the PASCS and SCS groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Any reference criteria were not obtained that surely distinguish patients with PASCS from those with PA or SCS. However, clinicians should suspect the presence of concurrent SCS in patients with PA when detecting a relatively large adrenal tumor on the CT scans.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12902-020-0490-0","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T19:02:57Z","timestamp":1578942177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical characterization of patients with primary aldosteronism plus subclinical Cushing\u2019s syndrome"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-7108","authenticated-orcid":false,"given":"Shigemitsu","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Hikima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kabeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Isshiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"490_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1210\/jc.2003-031337","volume":"89","author":"P Mulatero","year":"2004","unstructured":"Mulatero P, Stowasser M, Loh KC, Fardella CE, Gordon RD, Mosso L, et al. 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The present study followed the recommendations of the Declaration of Helsinki and was approved by the ethics committee of Saitama Medical University (18049.01).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This manuscript does not report personal data such as individual details, images or videos; therefore, consent for publication is not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9"}}