{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:08:44Z","timestamp":1789240124446,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The incidence of type 1 diabetes mellitus (T1DM) increased worldwide.<\/jats:p>\n                <jats:p>The objective of the paper was to compare the incidence trend of T1DM in children and adolescents aged 0\u201319 and in adults under 30\u2009years of age in Serbia from 2006 to 2017. Additional aim was to compare incidence rates of T1DM and type 2 diabetes mellitus (T2DM) among adults aged 20\u201324 and 25\u201329\u2009years of age.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Trends and annual percentage change (APC) of the incidence rate with corresponding 95% confidence intervals (CI) were calculated by Joinpoint Regression Analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We found a significant increase of incidence in children aged 5\u20139 with the APC of 5.7% (95%CI: 2.3\u20139.1), and in children aged 10\u201314 with the APC of 2.1% (95%CI: 0.6\u20133.6). A significant decrease of incidence was determined in adolescents aged 15\u201319 with the APC -4.9% (95%CI: \u2212\u20098.9 to \u2013 0.7) and in adults aged 25\u201329 with the APC -7.3% (95%CI: \u2212\u200912.5 to \u2212\u20091.8).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The increase of incidence in children aged 0\u201314 and its decrease after 15\u2009years of age showed that T1DM is predominantly a metabolic disease of children in Serbia. A significant increase in incidence was recorded in two age groups, namely 5\u20139 and 10\u201314\u2009years of age. The highest increase was in children aged 5\u20139 and the highest incidence rate was in children aged 10\u201314. An insignificant increasing of T2DM incidence was observed in young adults aged 25\u201329. The increase in incidence rates in children, but not in young adults, suggests that the precipitating factors of children-onset disease may differ from those of adult-onset T1DM.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-020-0504-y","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T16:04:34Z","timestamp":1583769874000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidence trend of type 1 diabetes mellitus in Serbia"],"prefix":"10.1186","volume":"20","author":[{"given":"Ciric","family":"Vojislav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rancic","family":"Natasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pesic","family":"Milica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antic","family":"Slobodan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kocic","family":"Radivoj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radojkovic","family":"Danijela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radenkovic","family":"Sasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"504_CR1","unstructured":"World Health Organization. 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The Ethical approval was not required. Used publications don\u2019t include any personal data about patients. These publications consisted of aggregate data of incidence and mortality cases. The new setup of the Serbian Diabetes Registry implied its decentralization. The regional Registries are kept on the level of the administrative districts and are located at the Institutes of Public Health. All authors of the manuscript are involved in the continuous process of data collection.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent to publish is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"34"}}