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However, with regard to improvement of metabolic conditions SPK might still be a considerable treatment option for lean insulin dependent type 2 diabetics suffering from renal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical data (2001\u20132013) from all consecutive T1DM and T2DM patients who received a SPK or kidney transplant alone (KTA) at the University Hospital of Leipzig were analyzed. Donor, recipients and long-term endocrine, metabolic and graft outcomes were investigated for T1DM and T2DM-SPK recipients (transplanted upon a special request allocation by ET) and T2DM patients who received a KTA during the same period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty nine T1DM and 12 T2DM patients received a SPK and 26 T2DM patients received a KTA. Patient survival at 1 and 5\u2009years was 89.9 and 88.8% for the T1DM group, 91.7 and 83.3% for the T2DM group, and 92.3 and 69.2% for the T2DM KTA group, respectively (<jats:italic>p\u2009&lt;\u20090.01<\/jats:italic>). Actuarial pancreas graft survival for SPK recipients at 1 and 5\u2009years was 83.1 and 78.7% for the T1DM group and 91.7 and 83.3% for the T2DM group, respectively (<jats:italic>p\u2009=\u20090.71<\/jats:italic>). Kidney allograft survival at 5\u2009years was 79.8% for T1DM, 83.3% for T2DM, and 65.4% for T2DM KTA (<jats:italic>p\u2009&lt;\u20090.01<\/jats:italic>). Delayed graft function (DGF) rate was significantly higher in type 2 diabetics received a KTA. Surgical, immunological and infectious complications showed similar results for T1DM and T2DM recipients after SPK transplant and KTA, respectively. With regard to the lipid profile, the mean high-density lipoprotein (HDL)- cholesterol levels were significantly higher in T1DM recipients compared to T2DM patients before transplantation (<jats:italic>p\u2009=\u20090.02<\/jats:italic>) and remained significantly during follow up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrate that with regard to metabolic function a selected group of patients with T2DM benefit from SPK transplantation. Consensus guidelines and further studies for SPK transplant indications in T2DM patients are still warranted.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12902-020-0506-9","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T11:03:33Z","timestamp":1582801413000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Short and long-term metabolic outcomes in patients with type 1 and type 2 diabetes receiving a simultaneous pancreas kidney allograft"],"prefix":"10.1186","volume":"20","author":[{"given":"Hans-Michael","family":"Hau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Jahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-4653","authenticated-orcid":false,"given":"Maximilian","family":"Brunotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andri Arnosson","family":"Lederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz Maximilian","family":"Rasche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Seehofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"506_CR1","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1097\/MOT.0000000000000553","volume":"23","author":"TM Al-Qaoud","year":"2018","unstructured":"Al-Qaoud TM, Odorico JS, Redfield RR. 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