{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:02:34Z","timestamp":1791910954350,"version":"4.3.4"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Primary hyperparathyroidism is a rare condition of disease which can seldomly present as giant retrotrhyroideal cysts, complicating the localization of the adenoma to resect.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 56-year old female presented with hypercalcaemia of 3.38\u2009mmol\/L (2.2\u20132.65\u2009mmol\/L) and a history of breast cancer. A fast growing cystic parathyroidal adenoma was diagnosed by a multimodal approach including comprehensive diagnostic imaging (ultrasonography, scintigraphies, dynamic MRI) and cytopathological investigations after ultrasonography-guided puncture. The patient was cured by surgical extraction of the whole adenoma. In retrospect, the rapid growth was most likely induced by cinacalcet (initially 30\u2009mg\/d, later 60\u2009mg\/d) therapy which the patient received for few months only. Primary hyperparathyroidism was ascertained because surgical removal of the solitary adenoma cured the patient. Furthermore, there was no relevant renal insufficiency or history of prolonged calcium-level deregulation.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This phenomenon of cystic degeneration of parathyroidal adenoma under therapy with cinacalcet has previously been described in secondary hyperparathyroidism, but not in primary hyperparathyroidism and should be considered in diagnostic approach.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12902-020-0532-7","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T15:04:34Z","timestamp":1587395074000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-8118","authenticated-orcid":false,"given":"Christoph","family":"Werner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-7310","authenticated-orcid":false,"given":"Amelie","family":"Lupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Mtuka-Pardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Kloos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Aschenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Biermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-3851","authenticated-orcid":false,"given":"Martin","family":"Freesmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3447-4971","authenticated-orcid":false,"given":"Philipp","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"532_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1472-6823-12-14","volume":"12","author":"A Asghar","year":"2012","unstructured":"Asghar A, Ikram M, Islam N. A case report: Giant cystic parathyroid adenoma presenting with parathyroid crisis after vitamin D replacement. BMC Endocr Disord. 2012;12:14.","journal-title":"BMC Endocr Disord"},{"key":"532_CR2","doi-asserted-by":"publisher","first-page":"3745239","DOI":"10.1155\/2018\/3745239","volume":"2018","author":"Y Hu","year":"2018","unstructured":"Hu Y, Cui M, Xia Y, Su Z, Zhang X, Liao Q, et al. The clinical features of cystic parathyroid adenoma in Chinese population: a single-center experience. Int J Endocrinol. 2018;2018:3745239.","journal-title":"Int J Endocrinol"},{"issue":"6","key":"532_CR3","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.2214\/AJR.10.4472","volume":"195","author":"NA Johnson","year":"2010","unstructured":"Johnson NA, Yip L, Tublin ME. Cystic parathyroid adenoma: sonographic features and correlation with 99mTc-sestamibi SPECT findings. AJR Am J Roentgenol. 2010;195(6):1385\u201390.","journal-title":"AJR Am J Roentgenol"},{"issue":"11","key":"532_CR4","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1016\/j.ejrad.2012.05.023","volume":"81","author":"R Aschenbach","year":"2012","unstructured":"Aschenbach R, Tuda S, Lamster E, Meyer A, Roediger H, Stier A, et al. Dynamic magnetic resonance angiography for localization of hyperfunctioning parathyroid glands in the reoperative neck. Eur J Radiol. 2012;81(11):3371\u20137.","journal-title":"Eur J Radiol"},{"issue":"12","key":"532_CR5","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1002\/jum.15066","volume":"38","author":"M Freesmeyer","year":"2019","unstructured":"Freesmeyer M, Kuhnel C, Guhne F, Seifert P. Standard needle magnetization for ultrasound needle guidance: first clinical experiences in fine-needle aspiration cytology of thyroid nodules. J Ultrasound Med. 2019;38(12):3311 [Epub ahead of print].","journal-title":"J Ultrasound Med"},{"issue":"4","key":"532_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/1744-9987.12292","volume":"19","author":"S Yamada","year":"2015","unstructured":"Yamada S, Tokumoto M, Taniguchi M, Toyonaga J, Suehiro T, Eriguchi R, et al. Two years of Cinacalcet hydrochloride treatment decreased parathyroid gland volume and serum parathyroid hormone level in hemodialysis patients with advanced secondary hyperparathyroidism. Ther Apher Dial. 2015;19(4):367\u201377.","journal-title":"Ther Apher Dial"},{"issue":"9","key":"532_CR7","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1136\/jclinpath-2011-200100","volume":"64","author":"K Sumida","year":"2011","unstructured":"Sumida K, Nakamura M, Ubara Y, Marui Y, Tanaka K, Takaichi K, et al. Histopathological alterations of the parathyroid glands in haemodialysis patients with secondary hyperparathyroidism refractory to cinacalcet hydrochloride. J Clin Pathol. 2011;64(9):756\u201360.","journal-title":"J Clin Pathol"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-020-0532-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-020-0532-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-020-0532-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T23:30:33Z","timestamp":1618875033000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-020-0532-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["532"],"URL":"https:\/\/doi.org\/10.1186\/s12902-020-0532-7","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]},"assertion":[{"value":"5 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethics approval was not necessary for the reported investigations, as they were performed in routine clinical setting and therapeutic intention.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Patient provided written consent in reporting her case in an international published medical journal, including clinical details along with any identifying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no coompeting interest, especially not belonging drugs and medical products named in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"53"}}