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It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two hundred seven subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent\n                      <jats:italic>t-<\/jats:italic>\n                      test or Nonparametric test was used to detect differences between PCOS and control groups. Spearman\u2019s correlation analysis was used to examine the association of the serum Fetuin-A with other parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2\u2009\u03bcg\/L for most women without PCOS (95%). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9\u2009\u00b1\u2009119.3 vs. 313.8\u2009\u00b1\u200960.5\u2009\u03bcg\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009\u00a00.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6\u2009\u03bcg\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-020-0538-1","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T03:03:49Z","timestamp":1589857429000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome"],"prefix":"10.1186","volume":"20","author":[{"given":"Sha","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yirui","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"538_CR1","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1530\/EJE-11-0840","volume":"166","author":"G Don\u00e0","year":"2012","unstructured":"Don\u00e0 G, Sabbadin C, Fiore C, Bragadin M, Giorgino FL, Ragazzi E, Clari G, Bordin L, Armanini D. 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