{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:19:06Z","timestamp":1772165946420,"version":"3.50.1"},"reference-count":4,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N020588\/1"],"award-info":[{"award-number":["MR\/N020588\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many young adults with Duchenne Muscular Dystrophy (DMD) receive long-term glucocorticoids (GC). GC can cause hypogonadotrophic hypogonadism and adolescents may therefore be candidates for pubertal induction. It is unclear whether men with DMD on or off GC have age-appropriate endogenous testosterone production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We undertook a quality improvement project to assess the feasibility of measuring salivary testosterone (SalT) levels in men with DMD at home. A Sal-T sampling kit was sent by post to all patients with DMD, aged 17 and older, registered at the John Walton Muscular Centre in Newcastle (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200975). Submitted Sal-T samples were collected and submitted for analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-eight out of seventy-five patients returned samples (age range: 17\u201334\u2009years). 6\/28 samples were unsuitable for analysis. Overall Sal-T levels (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200922) were significantly lower than in the healthy population (178\u2009\u00b1\u2009107 v 287\u2009\u00b1\u2009109\u2009pmol\/l,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.0001). Sal-T was lower in those on GC compared to those off GC (144\u2009\u00b1\u200981 versus 218\u2009\u00b1\u2009125\u2009pmol\/l,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.05). Three patients were unable to collect a sample due to ventilator dependence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sal T can provide information about androgen status in DMD patients at home, overcoming barriers such as mobility difficulties and challenging venepuncture. However we only obtained samples in a minority of patients suggesting that Sal-T measurement may not be appropriate or acceptable to everyone. There needs to be a more detailed exploration of the barriers to sample submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-021-00727-4","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T07:03:43Z","timestamp":1618038223000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Measurement of salivary testosterone in adolescents and young men with Duchenne muscular dystrophy"],"prefix":"10.1186","volume":"21","author":[{"given":"Yolanda Alins","family":"Sahun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Cheetham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Boot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Straub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-5174","authenticated-orcid":false,"given":"Claire L.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,10]]},"reference":[{"issue":"3","key":"727_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S1474-4422(18)30024-3","volume":"17","author":"DJ Birnkrant","year":"2018","unstructured":"Birnkrant DJ, Bushby K, Bann CM, Apkon SD, Blackwell A, Brumbaugh D, et al. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and neuromuscular, rehabilitation, endocrine, and gastrointestinal and nutritional management. Lancet Neurol. 2018;17(3):251\u201367. https:\/\/doi.org\/10.1016\/S1474-4422(18)30024-3.","journal-title":"Lancet Neurol"},{"issue":"6","key":"727_CR2","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1055\/s-0035-1563696","volume":"46","author":"CL Wood","year":"2015","unstructured":"Wood CL, Cheetham TD, Guglieri TM, Bushby K, Owen C, Johnstone H, et al. Testosterone treatment of pubertal delay in Duchenne muscular dystrophy. Neuropediatrics. 2015;46(6):371\u20136. https:\/\/doi.org\/10.1055\/s-0035-1563696.","journal-title":"Neuropediatrics."},{"key":"727_CR3","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1177\/0004563213506412","volume":"52","author":"BG Keevil","year":"2014","unstructured":"Keevil BG, MacDonald P, Macdowall W, Lee DM, Wu FC, the NATSAL team. Salivary testosterone measurement by liquid chromatography tandem mass spectrometry in adult males and females. Ann Clin Biochem. 2014;52:368\u201378.","journal-title":"Ann Clin Biochem"},{"issue":"1","key":"727_CR4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1210\/js.2016-1029","volume":"1","author":"BG Keevil","year":"2017","unstructured":"Keevil BG, Clifton S, Tanton C, Macdowall W, Copas AJ, Lee DM, et al. Distribution of salivary testosterone in men and women in a British general population-based sample: the third National Survey of sexual attitudes and life-styles (Natsal-3). J Endocr Soc. 2017;1(1):14\u201325. https:\/\/doi.org\/10.1210\/js.2016-1029.","journal-title":"J Endocr Soc"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-021-00727-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-021-00727-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-021-00727-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T07:04:22Z","timestamp":1618038262000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-021-00727-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,10]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["727"],"URL":"https:\/\/doi.org\/10.1186\/s12902-021-00727-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-26210\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-26210\/v1","asserted-by":"object"}]},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,10]]},"assertion":[{"value":"30 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The QI project was discussed with the Chair of NRES Committee North East- Newcastle and North Tyneside, who felt that ethical approval or consent was not required for the project. Consent for publication was not obtained from patients due to the QI nature, with only anonymised data included in the publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There are no competing interests to be declared.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"63"}}