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The value of measuring tumour volumes before and after surgery, and its influence on endocrine outcomes and further treatment of the residual or recurrent tumour are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from patients who underwent endoscopic TSS for a NFPMA (2009\u20132018) in a UK tertiary centre were analysed for pre- and post-operative endocrine and surgical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 173 patients with NFPMA, 159 (61% male) were treatment na\u00efve. At presentation, 76.2% (77\/101) had \u22651 pituitary axis deficit. Older age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) was an independent predictor for multiple hormonal deficiencies. Preoperative tumour volume did not correlate with degree of hypopituitarism. Postoperative tumour volume and extent of tumour resection were not predictive of new onset hypopituitarism. Hormonal recovery was observed in 16 patients (20.8%) with impaired pituitary function, with the greatest recovery in the hypothalamic-pituitary-adrenal axis (21.2%, 7\/33). A larger residual tumour volume was predictive of adjuvant radiotherapy (3.40 vs. 1.24\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and likelihood for repeat surgery (5.40 vs. 1.67cm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pre- and post-operative NFPMA volumes fail to predict the number of pituitary hormone deficits, however, greater post-operative residual volumes increase the likelihood of further intervention to control tumour growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-021-00777-8","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T16:03:03Z","timestamp":1623340983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Post-operative volumes following endoscopic surgery for non-functioning pituitary macroadenomas are predictive of further intervention, but not endocrine outcomes"],"prefix":"10.1186","volume":"21","author":[{"given":"K.","family":"Seejore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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Since it was undertaken using retrospective de-identified data collected during the course of routine care by the direct care team as part of usual practice, no informed consent was requested from the patients. This was acknowledged by the local Research and Innovation department at Leeds Teaching Hospitals NHS Trust who reviewed the study methods, confirmed waiver of consent and concluded that the study did not require Health Research Authority (HRA) approval and therefore no NHS Research Ethics Committee (REC) review. Research data for this study was obtained from the neurosurgical database created and maintained by the local pituitary surgeons at LTHT (neurosurgeons NP and AT and ENT surgeons PN and TW) as part of routine postoperative practice. No administrative permissions were required to access this anonymized data provided by co-authors NP, AT, PN and TW who shared ownership rights. All methods were carried out in accordance with relevant guidelines and regulations for medical research involving human subjects of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"116"}}