{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:56:14Z","timestamp":1783137374487,"version":"3.54.6"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Madelung\u2019s disease (MD) is a rare disorder of fat storage characterized by the presence of diffuse, symmetrical deposition of subcutaneous fat around the neck, shoulder, arm, trunk and thigh. Although its cause is not fully understood, this benign condition is commonly presented among adult males with Mediterranean origin and history of alcohol abuse. Patients often presents with compression of vital structures, cosmetic disfigurement and associated psychosocial problems and systemic comorbidities. It is often under-recognized by physicians, possibly due to obliviousness of the condition and often misdiagnosed as obesity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a 65-year-old non-alcoholic black Ethiopian man, presented with a slowly growing body fat in his trunk and proximal limbs associated by multiple joint and back pain which got worse recently. He denied any history of chronic alcohol use. On examination, huge, bilateral, non-tender, soft, globular masses in his torso, shoulder, arm and thigh with bilateral breast enlargement. On investigation his biochemical profile was normal except hyperuricemia (10.6\u00a0mg\/dl). Imaging of the cervical and lumbar vertebrae showed excess subcutaneous fat depositions with degenerative disc disease. Biopsy from the mass revealed non-encapsulated lipoma and he was diagnosed with type II MD. We treated his pain with supportive therapy and discharged in stable condition. The patient deferred surgical treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Madelung\u2019s disease is often reported among white adult males with chronic alcoholism. However, our case reported a black man without the typical risk factor which was misdiagnosed as obesity. Hence, clinicians should be aware of MD and need to consider it in their differential diagnosis when encountered with a patient having progressive centripetal fat deposition with or without a history of alcoholism and systemic comorbidities. As early detection of this disorder helps to avoid diagnostic delays and prevent complications through timely interventions which will in turn improves patient quality of life.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-021-00803-9","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T13:02:29Z","timestamp":1625317349000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Madelung\u2019s disease in a non-alcoholic Ethiopian male patient mistaken for obesity: a case report"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-7148","authenticated-orcid":false,"given":"Yared Zenebe","family":"Zewde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,3]]},"reference":[{"key":"803_CR1","doi-asserted-by":"crossref","unstructured":"Meningaud JP, Pitak-Arnnop P, Bertrand JC. Multiple symmetric lipomatosis: case report and review of the literature. J Oral Maxillofac Surg. 2007;65(7):1365-9.","DOI":"10.1016\/j.joms.2005.10.045"},{"issue":"2","key":"803_CR2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s00266-004-3123-5","volume":"28","author":"R Gonz\u00e1lez-Garc\u00eda","year":"2004","unstructured":"Gonz\u00e1lez-Garc\u00eda R, Rodriguez-Campo FJ, Sastre-P\u00e9rez J, Mu\u00f1oz-Guerra MF. Benign symmetric lipomatosis (Madelung\u2019s disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108\u201312.","journal-title":"Aesthetic Plast Surg"},{"issue":"4","key":"803_CR3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3346\/jkms.1988.3.4.163","volume":"3","author":"MS Lee","year":"1988","unstructured":"Lee MS, Lee MH, Hur KB. Multiple symmetric lipomatosis. J Korean Med Sci. 1988;3(4):163\u20137.","journal-title":"J Korean Med Sci"},{"issue":"4","key":"803_CR4","first-page":"174","volume":"11","author":"M Zuber","year":"2006","unstructured":"Zuber M, Pittasch D. Benign symmetric lipomatosis (Launois-Bensaude syndrome).\u00a0 A rare cause of muscular weakness. Eur J Med Res. 2006;11(4):174\u20137.","journal-title":"Eur J Med Res"},{"key":"803_CR5","doi-asserted-by":"crossref","unstructured":"Cobos Salinas M, Sanchez-De la Torre L. Y. Madelung\u2019s Disease with polyneuropathy in a non-alcoholic Mexican-American male. Med Case Rep Rev. 2019;2(1). Available from: https:\/\/www.oatext.com\/madelungs-disease-with-polyneuropathy-in-a-non-alcoholic-mexican-american-male.php. [cited 14 Mar 2021]","DOI":"10.15761\/MCRR.1000121"},{"key":"803_CR6","doi-asserted-by":"crossref","unstructured":"Zhang WJ, Jiang H, Zhang JL, Zhang YF, Yi J, Liao JC, Zhao YZ. Surgical treatment of multiple symmetric lipomatosis (Madelung's disease): a single-center experience. J Oral Maxillofac Surg. 2011;69(9):2448-51.","DOI":"10.1016\/j.joms.2011.03.017"},{"key":"803_CR7","doi-asserted-by":"crossref","unstructured":"Suresh Chandran CJ, Godge YR, Oak PJ, Ravat SH. Madelung's disease with myopathy. Ann Indian Acad Neurol. 2009;12(2):131-2.","DOI":"10.4103\/0972-2327.53086"},{"key":"803_CR8","doi-asserted-by":"crossref","unstructured":"Ray S, Chakraborty PP, Pramanik S, Chowdhury S. Bilateral breast enlargement in a chronic alcoholic: do not miss Madelung's disease. BMJ Case Rep. 2016;2016:bcr2016215082.","DOI":"10.1136\/bcr-2016-215082"},{"key":"803_CR9","doi-asserted-by":"publisher","first-page":"3975974","DOI":"10.1155\/2018\/3975974","volume":"2018","author":"CY Chen","year":"2018","unstructured":"Chen CY, Fang QQ, Wang XF, Zhang MX, Zhao WY, Shi BH, Wu LH, Zhang LY, Tan WQ. Madelung\u2019s disease: lipectomy or liposuction? Biomed Res Int. 2018;2018:3975974. https:\/\/doi.org\/10.1155\/2018\/3975974 PMID: 29682541; PMCID: PMC5840946.","journal-title":"Biomed Res Int"},{"issue":"5","key":"803_CR10","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/SAP.0b013e31827f5295","volume":"73","author":"F Bassetto","year":"2014","unstructured":"Bassetto F, Scarpa C, De Stefano F, Busetto L. Surgical treatment of multiple symmetric lipomatosis with ultrasound assisted liposuction. Ann Plast Surg. 2014;73(5):559\u201362.","journal-title":"Ann Plast Surg"},{"key":"803_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-28043-X","volume-title":"Liposuction","author":"MA Shiffman","year":"2006","unstructured":"Shiffman MA, Di Giuseppe A. Liposuction. Berlin, Heidelberg: Springer; 2006."},{"issue":"1","key":"803_CR12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.soard.2014.05.004","volume":"11","author":"M Tremp","year":"2015","unstructured":"Tremp M, Wettstein R, Tchang LA, Schaefer DJ, Rieger UM, Kalbermatten DF. Power-assisted liposuction (PAL) of multiple symmetric lipomatosis (MSL) - a longitudinal study. Surg Obesity Relat Dis. 2015;11(1):155\u201360.","journal-title":"Surg Obesity Relat Dis"},{"issue":"1","key":"803_CR13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1746-1596-7-116","volume":"7","author":"M Borriello","year":"2012","unstructured":"Borriello M, Lucidi A, Carbone A, Iannone V, Ferrandina G. Malignant transformation of Madelung\u2019s disease in a patient with a coincidental diagnosis of breast cancer: a case report. Diagn Pathol. 2012;7(1):16.","journal-title":"Diagn Pathol"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-021-00803-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-021-00803-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-021-00803-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T13:03:50Z","timestamp":1625317430000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-021-00803-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,3]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["803"],"URL":"https:\/\/doi.org\/10.1186\/s12902-021-00803-9","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,3]]},"assertion":[{"value":"15 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors\u2019 institution does not require ethical approval for publication of a case report.Written informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient gave a written informed consent for participation in this case report and publication of his clinical details and images. The signed consent form is available on request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author declares that he has no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"142"}}