{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:11:54Z","timestamp":1793232714201,"version":"4.5.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The contribution of vitamin D to thyroid disorders has received paramount attention; however, results are mixed. Hence, we designed a systematic review and meta-analysis to obtain a definitive conclusion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The search included PubMed, ISI Web of Science, Scopus, and Google Scholar databases up to March 2021 to collect available papers reporting the relationship between serum levels of vitamin D and thyroid disorders. The pooled effect was reported as weighted mean difference (WMD) and 95% confidence interval (CI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Out of 6123 datasets, 42 were eligible to get into this systematic review and meta-analysis. Serum vitamin D was markedly lower in autoimmune thyroid diseases (AITD) (WMD \u2212\u20093.1\u2009ng\/dl; 95% CI, \u2212\u20095.57 to \u2212\u20090.66; <jats:italic>P<\/jats:italic>\u00a0=\u20090.013; I<jats:sup>2<\/jats:sup>\u00a0=\u200999.9%), Hashimoto\u2019s thyroiditis (HT) (WMD \u2212\u20096.05\u2009ng\/dl; 95% CI, \u2212\u20098.35 to \u2212\u20093.75; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001; I<jats:sup>2<\/jats:sup>\u00a0=\u200991.0%) and hypothyroidism patients (WMD \u2212\u200913.43\u2009ng\/dl; 95% CI, \u2212\u200926.04 to \u2212\u20090.81; <jats:italic>P<\/jats:italic>\u00a0=\u20090.03; I<jats:sup>2<\/jats:sup>\u00a0=\u200999.5%), but not in subjects with Graves\u2019 disease (GD) (WMD \u2212\u20094.14\u2009ng\/dl; 95% CI, \u2212\u20098.46 to 0.17; <jats:italic>P<\/jats:italic>\u00a0=\u20090.06; I<jats:sup>2<\/jats:sup>\u00a0=\u200997.5%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings suggested lower vitamin D levels in patients with hypothyroidism, AITD, and HT compared to healthy subjects. However, the link between serum vitamin D and GD was only significant among subjects \u226540\u2009years old.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-021-00831-5","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T11:03:14Z","timestamp":1629716594000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies"],"prefix":"10.1186","volume":"21","author":[{"given":"Sorour","family":"Taheriniya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Arab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Hadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmannan","family":"Fadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1194-9687","authenticated-orcid":false,"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,21]]},"reference":[{"issue":"1","key":"831_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s12020-015-0547-4","volume":"50","author":"T Skaaby","year":"2015","unstructured":"Skaaby T, Husemoen LLN, Thuesen BH, Linneberg A. 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