{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:31:16Z","timestamp":1784665876923,"version":"3.55.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>exposure to iodinated contrast media (ICM) can cause hyperthyroidism, due to disruption of thyroid hormone regulation. Although rare, it can have severe consequences and can lead to fatal complications. Current guidelines do not recommend standard laboratory testing of the thyroid function prior to ICM exposure. Prophylactic treatment of patients at higher risk of hyperthyroidism is not advised.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>we report the case of an 82-year-old woman who developed ICM induced hyperthyroidism after undergoing a chest computed tomography (CT). One month after ICM administration she presented with pneumonia at the emergency department. Hyperthyroidism was found with concomitant tachycardia, which was hard to control. As a result of hyperthyroidism and coincidental pneumonia the patient developed heart failure and died of myocardial ischemia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>this case report underlines the importance of close monitoring of high-risk patients after ICM exposure. Clinicians should be aware of the risk of hyperthyroidism and potential severe complications. The use of ICM needs careful consideration, especially in the elderly who suffer more often from multinodular goitre.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-021-00870-y","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T11:31:08Z","timestamp":1634729468000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Heart failure as a serious complication of iodinated contrast-induced hyperthyroidism: case-report"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0246-2781","authenticated-orcid":false,"given":"Sofie M.","family":"Diepenbroek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"de Jonghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"van Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Seebus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"issue":"3","key":"870_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1590\/2359-3997000000143","volume":"60","author":"I Iakovou","year":"2016","unstructured":"Iakovou I, Zapandiotis A, Mpalaris V, Goulis DG. Radio-contrast agent-induced hyperthyroidism: Case report and review of the literature. Arch Endocrinol Metab. 2016;60(3):287\u20139.","journal-title":"Arch Endocrinol Metab"},{"key":"870_CR2","doi-asserted-by":"publisher","unstructured":"Alkhuja S, Pyram R, Odeyemi O. In the eye of the storm: Iodinated contrast medium induced thyroid storm presenting as cardiopulmonary arrest. Hear Lung J Acute Crit Care. 2013;42(4):267\u20139. Available from: https:\/\/doi.org\/10.1016\/j.hrtlng.2013.04.002.","DOI":"10.1016\/j.hrtlng.2013.04.002"},{"key":"870_CR3","first-page":"2014","volume":"2015","author":"A Dave","year":"2015","unstructured":"Dave A, Ludlow J, Malaty J. Thyrotoxicosis: An under-recognised aetiology. BMJ Case Rep. 2015;2015:2014\u20136.","journal-title":"BMJ Case Rep"},{"issue":"2","key":"870_CR4","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1503\/cmaj.120734","volume":"185","author":"P Dunne","year":"2013","unstructured":"Dunne P, Kaimal N, MacDonald J, Syed AA. Iodinated contrast-induced thyrotoxicosis. Can Med Assoc J. 2013;185(2):144\u20137.","journal-title":"Can Med Assoc J"},{"issue":"2","key":"870_CR5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1001\/archinternmed.2011.677","volume":"172","author":"CM Rhee","year":"2012","unstructured":"Rhee CM, Bhan I, Alexander EK, Brunelli SM. Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism. Arch Intern Med. 2012;172(2):153\u20139.","journal-title":"Arch Intern Med"},{"key":"870_CR6","unstructured":"Nederlandse Vereniging voor Radiologie. Richtlijn voorzorgsmaatregelen bij jodiumhoudende contrastmiddelen. 2007."},{"key":"870_CR7","unstructured":"Nederlandse Internisten Vereniging. Richtlijn Schildklierfunctiestoornissen Revisie 2012. Ned Internisten Ver. 2012;224."},{"key":"870_CR8","unstructured":"ESUR. ESUR Guidelines on contrast media. esur.org. 2012."},{"issue":"9","key":"870_CR9","doi-asserted-by":"publisher","first-page":"3372","DOI":"10.1210\/JC.2015-2329","volume":"100","author":"E Kornelius","year":"2015","unstructured":"Kornelius E, Chiou JY, Yang YS, Peng CH, Lai YR, Huang CN. Iodinated contrast media increased the risk of thyroid dysfunction: A 6-year retrospective cohort study. J Clin Endocrinol Metab. 2015;100(9):3372\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"870_CR10","doi-asserted-by":"crossref","unstructured":"Ledingham D, Carey P, Junejo S. The dangers of iodine-based contrasts in an elderly patient with thyroid disease. BMJ Case Rep. 2015;2015(February 2018).","DOI":"10.1136\/bcr-2014-207657"},{"issue":"4","key":"870_CR11","first-page":"363","volume":"13","author":"S \u00d6zkan","year":"2013","unstructured":"\u00d6zkan S, Oysu AS, Kayata\u015f K, Demirtun\u00e7 R, Eren M, Uslu H, et al. Thyroid functions after contrast agent administration for coronary angiography: a prospective observational study in euthyroid patients. Anadolu Kardiyol Derg. 2013;13(4):363\u20139.","journal-title":"Anadolu Kardiyol Derg"},{"issue":"2","key":"870_CR12","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/cen.13494","volume":"88","author":"N Bonelli","year":"2018","unstructured":"Bonelli N, Rossetto R, Castagno D, Anselmino M, Vignolo F, Parasiliti Caprino M, et al. Hyperthyroidism in patients with ischaemic heart disease after iodine load induced by coronary angiography: Long-term follow-up and influence of baseline thyroid functional status. Clin Endocrinol (Oxf). 2018;88(2):272\u20138.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"870_CR13","doi-asserted-by":"publisher","first-page":"6092","DOI":"10.1210\/jc.2004-0728","volume":"89","author":"E Fricke","year":"2004","unstructured":"Fricke E, Fricke H, Esdorn E, Kammeier A, Lindner O, Kleesiek K, et al. Scintigraphy for risk stratification of iodine-induced thyrotoxicosis in patients receiving contrast agent for coronary angiography: A prospective study of patients with low thyrotropin. J Clin Endocrinol Metab. 2004;89(12):6092\u20136.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"870_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jendso\/bvab040","volume":"5","author":"Z Waqar","year":"2021","unstructured":"Waqar Z, Avula S, Shah J, Ali SS. Cardiovascular events in patients with thyroid storm. J Endocr Soc. 2021;5(6):1\u20138.","journal-title":"J Endocr Soc"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-021-00870-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-021-00870-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-021-00870-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T08:15:25Z","timestamp":1635236125000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-021-00870-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["870"],"URL":"https:\/\/doi.org\/10.1186\/s12902-021-00870-y","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,20]]},"assertion":[{"value":"12 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the legal guardian of the patient for publication of this case report along with clinical details and images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"207"}}