{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:19:28Z","timestamp":1774282768296,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"joint funds for the innovation of science and technology, fujian province","award":["2018Y9018"],"award-info":[{"award-number":["2018Y9018"]}]},{"name":"joint funds for the innovation of science and technology, fujian province","award":["2018Y9015"],"award-info":[{"award-number":["2018Y9015"]}]},{"name":"joint funds for the innovation of science and technology, fujian province","award":["2018Y9093"],"award-info":[{"award-number":["2018Y9093"]}]},{"DOI":"10.13039\/501100018534","name":"medical innovation project of fujian province","doi-asserted-by":"crossref","award":["2018-CX-17"],"award-info":[{"award-number":["2018-CX-17"]}],"id":[{"id":"10.13039\/501100018534","id-type":"DOI","asserted-by":"crossref"}]},{"name":"guiding social development project of fujian province","award":["2018Y0035"],"award-info":[{"award-number":["2018Y0035"]}]},{"name":"startup fund for scientific research, fujian medical university","award":["2017XQ1037"],"award-info":[{"award-number":["2017XQ1037"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Prophylactic central lymph node dissection (PCND) was a basic consensus for patients with papillary thyroid carcinoma (PTC) in China. However, unilateral or bilateral central lymph node dissection (CND) was still controversial. This study aimed at investigating the safety and long-term benefit for the patients undergone with bilateral central lymph node dissection (BCCD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>581 patients were enrolled and divided randomly into the test and control groups according to range of CND. 285 patients were prospectively assigned to undergo thyroid lobectomy plus BCND in the test group, other 296 patients were assigned to undergo thyroid lobectomy plus ipsilateral central lymph node dissection (ICND) in the control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We found that the numbers of total LN and pN1a in the test group were more than that of the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.002,0.004), but there was no difference in the number of metastasized lymph nodes (<jats:italic>p<\/jats:italic>\u2009=\u20090.857) and tumor recurrence (<jats:italic>p<\/jats:italic>\u2009=\u20090.308). Additionally, in the aspect of postoperative complication (1\u2009day after surgery), the serum levels of parathyroid hormone in the BCND group were lower than that in the ICND group (<jats:italic>P<\/jats:italic>\u2009=\u20090.010), and the numbers of transient laryngeal nerve palsy were more than that(<jats:italic>p<\/jats:italic>\u2009=\u20090.033). Meanwhile, we further found that pathological tumor size larger than 1\u2009cm and tumor side lymph node metastasis were independent risk factors for contralateral central lymph node metastasis(<jats:italic>p<\/jats:italic>\u2009=\u20090.002,0.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>BCND may be an alternative for patients with tumor sizes larger than 1\u2009cm, but it would significantly increase the rate of transient vocal cord palsy, parathyroid auto transplantation and decreased PTH, but the risk of permanent complications was similar to the ICND group.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-021-00909-0","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T08:03:26Z","timestamp":1641283406000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prophylactic bilateral central neck dissection should be evaluated based on prospective randomized study of 581 PTC patients"],"prefix":"10.1186","volume":"22","author":[{"given":"Shouyi","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiafan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2025-4246","authenticated-orcid":false,"given":"Wenxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"issue":"1","key":"909_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s12020-018-1600-x","volume":"61","author":"S Yan","year":"2018","unstructured":"Yan S, Zhao W, Wang B, Zhang L. Standardization of simple auxiliary method beneficial to total endoscopic thyroidectomy on patients with PTC, based on retrospective study of 356 cases [J]. Endocrine. 2018;61(1):51\u20137. https:\/\/doi.org\/10.1007\/s12020-018-1600-x.","journal-title":"Endocrine"},{"issue":"1","key":"909_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid Cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid Cancer. 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Meanwhile all patients provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5"}}