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We aimed to identify abnormally expressed genes in peripheral blood mononuclear cells (PBMCs) of T1D and explore their possible molecular regulatory network.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Expression datasets were downloaded from the Gene Expression Omnibus (GEO) database. Then, the differentially expressed genes (DEGs) and differentially expressed miRNAs (DEmiRNAs) were identified, and functional enrichment and immune cell infiltration analysis were performed. The starBase, miRTarBase, TarBase, JASPAR, ENCODE, and TRRUST databases constructed the miRNA-mRNA-TF regulatory network. The ROC curves were plotted to evaluate the sensitivity and specificity of miRNAs and mRNAs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Result<\/jats:title>\n                <jats:p>A total of 216 DEGs directly or indirectly related to type I diabetes mellitus, natural killer cell-mediated cytotoxicity, Th1, and Th2 cell differentiation, and the IL-17 and <jats:italic>TNF<\/jats:italic> signaling pathways were obtained. The miRNA-mRNA-TF network indicates that miR-320a and <jats:italic>SOX5<\/jats:italic> are the only miRNAs and TFs that both target <jats:italic>ADM<\/jats:italic> and <jats:italic>RRAGD<\/jats:italic>. The ROC curves showed that <jats:italic>ADM<\/jats:italic> (0.9375), <jats:italic>RRAGD<\/jats:italic> (0.8958), and hsa-mir-320a (0.9417) had high accuracy in T1D diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The constructed regulatory networks, including miR-320a\/<jats:italic>ADM\/SOX5<\/jats:italic> and miR-320a\/<jats:italic>RRAGD\/SOX5,<\/jats:italic> may provide new insight into the mechanisms of development and progression in T1D.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-022-01038-y","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T13:04:48Z","timestamp":1652101488000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of miRNA-mRNA-TF regulatory networks in peripheral blood mononuclear cells of type 1 diabetes"],"prefix":"10.1186","volume":"22","author":[{"given":"Wanqiu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"issue":"9911","key":"1038_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","volume":"383","author":"MA Atkinson","year":"2014","unstructured":"Atkinson MA, Eisenbarth GS, Michels AW. 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