{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T22:16:37Z","timestamp":1786400197756,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Chinese Government, the Ministry of Science, and Technology of the People\u2019s Republic of China through the National Science and Technology Support Program","award":["No. 2015BAI04B09"],"award-info":[{"award-number":["No. 2015BAI04B09"]}]},{"DOI":"10.13039\/100012829","name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","doi-asserted-by":"crossref","award":["No. 2021DB02"],"award-info":[{"award-number":["No. 2021DB02"]}],"id":[{"id":"10.13039\/100012829","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Prevalence rates of hyperuricemia and gout are increasing. Clinical investigations of hyperuricemia-related risk factors aid in the early detection, prevention, and management of hyperuricemia and gout. Ongoing research is examining the association of obesity, dietary patterns, and blood pressure (BP) with serum uric acid (sUA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A cross-sectional study was conducted based on the National Health and Nutrition Examination Survey. The exposures included body mass index (BMI), dietary patterns, and BP. The outcome variable was sUA level. The weighted multivariate linear regression models and smooth curve fittings were used to assess the association of BMI, dietary patterns, and BP with sUA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There was a significantly positive correlation between BMI and sUA (\u03b2\u2009=\u20090.059, 95% CI: 0.054 to 0.064, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001). Overweight and obese individuals had higher sUA levels than those with the normal BMI (\u03b2\u2009=\u20090.451, 95% CI: 0.357 to 0.546, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001; \u03b2\u2009=\u20090.853, 95% CI: 0.760 to 0.946, P\u2009&lt;\u20090.00001; respectively). Dietary energy intake was positively correlated with sUA (\u03b2\u2009=\u20090.000, 95% CI: 0.000 to 0.000, <jats:italic>P<\/jats:italic>\u2009=\u20090.01057). Dietary intake of carbohydrate and fiber were negatively correlated with sUA (\u03b2\u2009=\u2009\u2212\u20090.001, 95% CI: \u2212\u20090.002 to \u2212\u20090.000, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001; \u03b2\u2009=\u2009\u2212\u20090.008, 95% CI: \u2212\u20090.011 to \u2212\u20090.004, <jats:italic>P<\/jats:italic>\u2009=\u20090.00001; respectively). Moreover, systolic BP was positively correlated with sUA (\u03b2\u2009=\u20090.006, 95% CI: 0.003 to 0.009, <jats:italic>P<\/jats:italic>\u2009=\u20090.00002). However, no statistical differences were found about the associations of dietary intake of total sugars, protein, total fat, cholesterol, and diastolic BP with sUA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The current cross-sectional investigation of a nationally representative sample of US participants showed that BMI, dietary energy intake, and systolic BP were positively correlated with sUA levels; dietary carbohydrate and fiber intake were negatively correlated with sUA levels. The findings might be helpful for the management and treatment of hyperuricemia and gout.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-022-01112-5","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T05:02:32Z","timestamp":1659675752000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Correlation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017\u20132018"],"prefix":"10.1186","volume":"22","author":[{"given":"Jia","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Yun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Jie","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"issue":"6","key":"1112_CR1","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/art.40807","volume":"71","author":"M Chen-Xu","year":"2019","unstructured":"Chen-Xu M, Yokose C, Rai SK, Pillinger MH, Choi HK. Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the National Health and nutrition examination survey, 2007-2016. Arthritis Rheumatol (Hoboken, NJ). 2019;71(6):991\u20139.","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"issue":"2","key":"1112_CR2","doi-asserted-by":"publisher","first-page":"e041919","DOI":"10.1136\/bmjopen-2020-041919","volume":"11","author":"J Zeng","year":"2021","unstructured":"Zeng J, Lawrence WR, Yang J, Tian J, Li C, Lian W, et al. Association between serum uric acid and obesity in Chinese adults: a 9-year longitudinal data analysis. BMJ Open. 2021;11(2):e041919.","journal-title":"BMJ Open"},{"key":"1112_CR3","doi-asserted-by":"publisher","first-page":"40009","DOI":"10.1038\/srep40009","volume":"7","author":"MY Chen","year":"2017","unstructured":"Chen MY, Zhao CC, Li TT, Zhu Y, Yu TP, Bao YQ, et al. Serum uric acid levels are associated with obesity but not cardio-cerebrovascular events in Chinese inpatients with type 2 diabetes. Sci Rep. 2017;7:40009.","journal-title":"Sci Rep"},{"issue":"1","key":"1112_CR4","doi-asserted-by":"publisher","first-page":"7841","DOI":"10.1038\/s41598-020-64884-7","volume":"10","author":"N Ali","year":"2020","unstructured":"Ali N, Miah R, Hasan M, Barman Z, Mou AD, Hafsa JM, et al. Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults. Sci Rep. 2020;10(1):7841.","journal-title":"Sci Rep"},{"issue":"6","key":"1112_CR5","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1002\/art.41247","volume":"72","author":"JD FitzGerald","year":"2020","unstructured":"FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, et al. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Rheumatol (Hoboken, NJ). 2020;72(6):879\u201395.","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"issue":"5","key":"1112_CR6","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1161\/HYPERTENSIONAHA.114.03757","volume":"64","author":"S Sedaghat","year":"2014","unstructured":"Sedaghat S, Pazoki R, Uitterlinden AG, Hofman A, Stricker BH, Ikram MA, et al. Association of uric acid genetic risk score with blood pressure: the Rotterdam study. Hypertension (Dallas, Tex : 1979). 2014;64(5):1061\u20136.","journal-title":"Hypertension (Dallas, Tex : 1979)"},{"issue":"5","key":"1112_CR7","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1097\/HJH.0000000000001980","volume":"37","author":"B De Becker","year":"2019","unstructured":"De Becker B, Borghi C, Burnier M, van de Borne P. Uric acid and hypertension: a focused review and practical recommendations. J Hypertens. 2019;37(5):878\u201383.","journal-title":"J Hypertens"},{"issue":"7","key":"1112_CR8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/ajh\/hpaa044","volume":"33","author":"LG Sanchez-Lozada","year":"2020","unstructured":"Sanchez-Lozada LG, Rodriguez-Iturbe B, Kelley EE, Nakagawa T, Madero M, Feig DI, et al. Uric acid and hypertension: an update with recommendations. Am J Hypertens. 2020;33(7):583\u201394.","journal-title":"Am J Hypertens"},{"issue":"Pt B","key":"1112_CR9","doi-asserted-by":"publisher","first-page":"105191","DOI":"10.1016\/j.envint.2019.105191","volume":"133","author":"F Zhu","year":"2019","unstructured":"Zhu F, Huang M, Jiao J, Zhuang P, Mao L, Zhang Y. Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to obesity: a population-based study. Environ Int. 2019;133(Pt B):105191.","journal-title":"Environ Int"},{"issue":"3","key":"1112_CR10","doi-asserted-by":"publisher","first-page":"262","DOI":"10.4274\/jcrpe.galenos.2018.2019.0241","volume":"11","author":"D \u00d6zalp K\u0131z\u0131lay","year":"2019","unstructured":"\u00d6zalp K\u0131z\u0131lay D, \u015een S, Ersoy B. Associations between serum uric acid concentrations and Cardiometabolic risk and renal injury in obese and overweight children. J Clin Res Pediatr Endocrinol. 2019;11(3):262\u20139.","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"8","key":"1112_CR11","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0026-0495(98)90346-8","volume":"47","author":"F Matsuura","year":"1998","unstructured":"Matsuura F, Yamashita S, Nakamura T, Nishida M, Nozaki S, Funahashi T, et al. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metab Clin Exp. 1998;47(8):929\u201333.","journal-title":"Metab Clin Exp"},{"key":"1112_CR12","first-page":"15","volume":"5","author":"E Russo","year":"2021","unstructured":"Russo E, Verzola D, Cappadona F, Leoncini G, Garibotto G, Pontremoli R, et al. The role of uric acid in renal damage - a history of inflammatory pathways and vascular remodeling. Vessel Plus. 2021;5:15.","journal-title":"Vessel Plus"},{"key":"1112_CR13","doi-asserted-by":"crossref","unstructured":"Yanai H, Adachi H, Hakoshima M, Katsuyama H. Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease. Int J Mol Sci. 2021;22(17):9221.","DOI":"10.3390\/ijms22179221"},{"issue":"6","key":"1112_CR14","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/BF03346397","volume":"31","author":"S Bo","year":"2008","unstructured":"Bo S, Gambino R, Durazzo M, Ghione F, Musso G, Gentile L, et al. Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction. J Endocrinol Investig. 2008;31(6):499\u2013504.","journal-title":"J Endocrinol Investig"},{"issue":"10","key":"1112_CR15","doi-asserted-by":"publisher","first-page":"e13911","DOI":"10.1111\/jfbc.13911","volume":"45","author":"F Zou","year":"2021","unstructured":"Zou F, Zhao X, Wang F. A review on the fruit components affecting uric acid level and their underlying mechanisms. J Food Biochem. 2021;45(10):e13911.","journal-title":"J Food Biochem"},{"issue":"8","key":"1112_CR16","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1039\/C8FO01917G","volume":"10","author":"Y Sun","year":"2019","unstructured":"Sun Y, Sun J, Zhang P, Zhong F, Cai J, Ma A. Association of dietary fiber intake with hyperuricemia in U.S. adults. Food Funct. 2019;10(8):4932\u201340.","journal-title":"Food Funct"},{"key":"1112_CR17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1743-7075-7-16","volume":"7","author":"SZ Sun","year":"2010","unstructured":"Sun SZ, Flickinger BD, Williamson-Hughes PS, Empie MW. Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab. 2010;7:16.","journal-title":"Nutr Metab"},{"key":"1112_CR18","doi-asserted-by":"crossref","unstructured":"Russo E, Leoncini G, Esposito P, Garibotto G, Pontremoli R, Viazzi F. Fructose and uric acid: major mediators of cardiovascular disease risk starting at pediatric age. Int J Mol Sci. 2020;21(12):4479.","DOI":"10.3390\/ijms21124479"},{"issue":"3","key":"1112_CR19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.bbagen.2016.11.042","volume":"1861","author":"C Kaneko","year":"2017","unstructured":"Kaneko C, Ogura J, Sasaki S, Okamoto K, Kobayashi M, Kuwayama K, et al. Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation. Biochimica et biophysica acta General subjects. 2017;1861(3):559\u201366.","journal-title":"Biochimica et biophysica acta General subjects"},{"issue":"1","key":"1112_CR20","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/art.20761","volume":"52","author":"HK Choi","year":"2005","unstructured":"Choi HK, Liu S, Curhan G. Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the third National Health and nutrition examination survey. Arthritis Rheum. 2005;52(1):283\u20139.","journal-title":"Arthritis Rheum"},{"issue":"9","key":"1112_CR21","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1093\/ajcn\/21.9.892","volume":"21","author":"CI Waslien","year":"1968","unstructured":"Waslien CI, Calloway DH, Margen S. Uric acid production of men fed graded amounts of egg protein and yeast nucleic acid. Am J Clin Nutr. 1968;21(9):892\u20137.","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"1112_CR22","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1136\/ard.42.2.123","volume":"42","author":"T Gibson","year":"1983","unstructured":"Gibson T, Rodgers AV, Simmonds HA, Court-Brown F, Todd E, Meilton V. A controlled study of diet in patients with gout. Ann Rheum Dis. 1983;42(2):123\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1112_CR23","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/978-1-4615-9140-5_36","volume":"122a","author":"F Matzkies","year":"1980","unstructured":"Matzkies F, Berg G, M\u00e4dl H. The uricosuric action of protein in man. Adv Exp Med Biol. 1980;122a:227\u201331.","journal-title":"Adv Exp Med Biol"},{"issue":"9","key":"1112_CR24","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.numecd.2019.05.055","volume":"29","author":"A Julibert","year":"2019","unstructured":"Julibert A, Bibiloni MDM, Tur JA. Dietary fat intake and metabolic syndrome in adults: a systematic review. Nutr Metab Cardiovasc Dis. 2019;29(9):887\u2013905.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"8","key":"1112_CR25","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/s41440-020-0481-6","volume":"43","author":"MA Lanaspa","year":"2020","unstructured":"Lanaspa MA, Andres-Hernando A, Kuwabara M. Uric acid and hypertension. Hypertens Res. 2020;43(8):832\u20134.","journal-title":"Hypertens Res"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-022-01112-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-022-01112-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-022-01112-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T05:02:41Z","timestamp":1659675761000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-022-01112-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1112"],"URL":"https:\/\/doi.org\/10.1186\/s12902-022-01112-5","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"assertion":[{"value":"11 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was granted ethical approval by the National Center for Health Statistics (NCHS). The study was carried out in accordance with the ethical standards of the responsible committee on human experimentation and with the 1975 Helsinki Declaration and its later amendments. All methods were performed in accordance with the relevant guidelines and regulations. The written informed consents were obtained from all participants or their proxies.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"196"}}