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Studies on its association with the clinical, metabolic, and immunologic characteristics in black African adult populations with new-onset diabetes are limited. This study aimed to describe the clinical, metabolic, and immunologic characteristics of a black Ugandan adult population with recently diagnosed diabetes and hypovitaminosis D.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Serum vitamin D concentrations were measured in 327 participants with recently diagnosed diabetes. Vitamin D deficiency, vitamin D insufficiency, and normal vitamin D status were defined as serum 25 hydroxyvitamin D levels of\u2009&lt;\u200920\u00a0ng\/ml, 21\u201329\u00a0ng\/ml, and\u2009\u2265\u200930\u00a0ng\/ml, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The median (IQR) age, glycated haemoglobin, and serum vitamin D concentration of the participants were 48\u00a0years (39\u201358), 11% (8\u201313) or 96\u00a0mmol\/mol (67\u2013115), and 24\u00a0ng\/ml (18\u201330), respectively. Vitamin D deficiency, vitamin D insufficiency, and normal vitamin D status were noted in 105 participants (32.1%), 140 participants (42.8%), and 82 participants (25.1%), respectively.<\/jats:p>\n                <jats:p>Compared with those having normal serum vitamin D levels, participants with vitamin D deficiency and insufficiency had higher circulating concentrations of interleukin (IL) 6 (29 [16\u201345] pg\/ml, 23 [14\u201340] pg\/ml vs 18 [14\u201332] pg\/ml, <jats:italic>p<\/jats:italic>\u2009=\u20090.01), and IL-8 (24 [86\u2013655] pg\/ml, 207 [81\u2013853] pg\/ml vs 98 [67\u2013224], <jats:italic>p<\/jats:italic>\u2009=\u20090.03). No statistically significant differences were noted in the markers of body adiposity, insulin resistance, and pancreatic beta-cell function between both groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Vitamin D deficiency and insufficiency were highly prevalent in our study population and were associated with increased circulating concentrations of pro-inflammatory cytokines. The absence of an association between pancreatic beta-cell function, insulin resistance, and low vitamin D status may indicate that the latter does not play a significant role in the pathogenesis of type 2 diabetes in our adult Ugandan population.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-022-01148-7","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T12:08:11Z","timestamp":1663243691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical, metabolic, and immunological characterisation of adult Ugandan patients with new-onset diabetes and low vitamin D status"],"prefix":"10.1186","volume":"22","author":[{"given":"Davis","family":"Kibirige","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Sekitoleko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Balungi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Kyosiimire-Lugemwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lumu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"issue":"11","key":"1148_CR1","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","volume":"74","author":"K Amrein","year":"2020","unstructured":"Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, K\u00f6stenberger M, TmavaBerisha A, Martucci G, Pilz S, Malle O. 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