{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:14:09Z","timestamp":1788383649061,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2020CFB300"],"award-info":[{"award-number":["2020CFB300"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The incidence of papillary thyroid cancer (PTC) concomitant with Hashimoto\u2019s thyroiditis (HT) is gradually increasing over the past decades. This study aims to identify differentially expressed lncRNAs between tumor tissues of PTC with or without HT and further to confer a better understanding of lncRNA-based competing endogenous RNA (ceRNA) network in PTC with HT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>GSE138198 containing tissue mRNA data and GSE192560 containing lncRNA data were utilized to perform differentially expression analysis. The ceRNA network was constructed based on miRNA-mRNA interactions merging with lncRNA-microRNA interactions. Functional enrichment analysis and protein\u2013protein interaction (PPI) analysis were performed. The mRNA levels of core genes in the PPI analysis in tumor tissues collected from 112 PTC patients including 35 cases coexistent with HT were determined by quantitative real-time polymerase chain reaction (qRT-PCR).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 57 genes and 40 lncRNAs, with value of |log2 fold change (FC)|\u2265\u20091 and the adjusted <jats:italic>P<\/jats:italic>-value\u2009&lt;\u20090.05, were deemed as differentially expressed genes and lncRNAs between PTC with and without HT. The pathways most significantly enriched by differentially expressed genes between PTC with and without HT were viral protein interaction with cytokine and cytokine receptor and cytokine-cytokine receptor interaction. CXCL10, CXCL9, CCL5, FCGR3A, and CCR2 owned degree values not less than 10 were deemed as core genes differentially expressed between PTC with and without HT. A total of 76 pairs of lncRNA-miRNA-mRNA ceRNA were obtained. Results of qRT-PCR partially demonstrated the bioinformatics results that the mRNA levels of CXCL10, CXCL9, CCL5, and CCR2 were remarkably elevated in tumor tissues collected from PTC patients coexistent with HT than those without HT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study offers a better understanding of the lncRNA-related ceRNA network involved in PTC with HT, providing novel key genes associated with PTC coexistent with HT.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-022-01173-6","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T07:02:58Z","timestamp":1666249378000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comprehensive analysis of lncRNA-mediated ceRNA regulatory networks and key genes associated with papillary thyroid cancer coexistent with Hashimoto\u2019s thyroiditis"],"prefix":"10.1186","volume":"22","author":[{"given":"Yuepeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueli","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"issue":"7","key":"1173_CR1","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S2213-8587(22)00101-2","volume":"10","author":"EK Alexander","year":"2022","unstructured":"Alexander EK, Cibas ES. Diagnosis of thyroid nodules. Lancet Diabetes Endocrinol. 2022;10(7):533\u20139.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10061","key":"1173_CR2","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1016\/S0140-6736(16)30172-6","volume":"388","author":"ME Cabanillas","year":"2016","unstructured":"Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet. 2016;388(10061):2783\u201395.","journal-title":"Lancet"},{"issue":"12","key":"1173_CR3","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.3390\/cancers14122908","volume":"14","author":"I Landa","year":"2022","unstructured":"Landa I. Advances in Thyroid Carcinoma. Cancers (Basel). 2022;14(12):2908.","journal-title":"Cancers (Basel)"},{"issue":"3","key":"1173_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41574-020-00448-z","volume":"17","author":"M Schlumberger","year":"2021","unstructured":"Schlumberger M, Leboulleux S. Current practice in patients with differentiated thyroid cancer. Nat Rev Endocrinol. 2021;17(3):176\u201388.","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"1173_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7\u201333.","journal-title":"CA Cancer J Clin"},{"key":"1173_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1146\/annurev-med-061512-105739","volume":"65","author":"T Carling","year":"2014","unstructured":"Carling T, Udelsman R. Thyroid cancer. Annu Rev Med. 2014;65:125\u201337.","journal-title":"Annu Rev Med"},{"issue":"1","key":"1173_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016;26(1):1\u2013133.","journal-title":"Thyroid"},{"issue":"9255","key":"1173_CR8","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","volume":"357","author":"F Balkwill","year":"2001","unstructured":"Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357(9255):539\u201345.","journal-title":"Lancet"},{"issue":"2","key":"1173_CR9","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.autrev.2014.10.016","volume":"14","author":"A Antonelli","year":"2015","unstructured":"Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P. Autoimmune thyroid disorders. Autoimmun Rev. 2015;14(2):174\u201380.","journal-title":"Autoimmun Rev"},{"key":"1173_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.semcancer.2019.05.019","volume":"64","author":"SM Ferrari","year":"2020","unstructured":"Ferrari SM, Fallahi P, Elia G, Ragusa F, Ruffilli I, Paparo SR, Antonelli A. Thyroid autoimmune disorders and cancer. Semin Cancer Biol. 2020;64:135\u201346.","journal-title":"Semin Cancer Biol"},{"key":"1173_CR11","doi-asserted-by":"publisher","first-page":"719820","DOI":"10.3389\/fcell.2021.719820","volume":"9","author":"W Wang","year":"2021","unstructured":"Wang W, Shen C, Zhao Y, Sun B, Qiu X, Yin S, Chen J, Li X. The Role of m6A RNA Methylation-Related lncRNAs in the Prognosis and Tumor Immune Microenvironment of Papillary Thyroid Carcinoma. Front Cell Dev Biol. 2021;9:719820.","journal-title":"Front Cell Dev Biol"},{"key":"1173_CR12","doi-asserted-by":"crossref","unstructured":"Wang W, Bai N, Li X. Comprehensive Analysis of the Prognosis and Drug Sensitivity of Differentiation-Related lncRNAs in Papillary Thyroid Cancer. Cancers (Basel). 2022;14(5):1353.","DOI":"10.3390\/cancers14051353"},{"issue":"2","key":"1173_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2013.223","volume":"10","author":"P Pallante","year":"2014","unstructured":"Pallante P, Battista S, Pierantoni GM, Fusco A. Deregulation of microRNA expression in thyroid neoplasias. Nat Rev Endocrinol. 2014;10(2):88\u2013101.","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"1173_CR14","first-page":"565","volume":"14","author":"I Leong","year":"2018","unstructured":"Leong I. A microRNA panel for thyroid nodules. Nat Rev Endocrinol. 2018;14(10):565.","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"1173_CR15","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12967-018-1640-2","volume":"16","author":"CN Fan","year":"2018","unstructured":"Fan CN, Ma L, Liu N. Systematic analysis of lncRNA-miRNA-mRNA competing endogenous RNA network identifies four-lncRNA signature as a prognostic biomarker for breast cancer. J Transl Med. 2018;16(1):264.","journal-title":"J Transl Med"},{"issue":"13","key":"1173_CR16","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.7150\/ijbs.62728","volume":"17","author":"K Li","year":"2021","unstructured":"Li K, Yao T, Zhang Y, Li W, Wang Z. NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential. Int J Biol Sci. 2021;17(13):3428\u201340.","journal-title":"Int J Biol Sci"},{"issue":"1","key":"1173_CR17","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s13046-018-0950-9","volume":"37","author":"H Liu","year":"2018","unstructured":"Liu H, Deng H, Zhao Y, Li C, Liang Y. LncRNA XIST\/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling. J Exp Clin Cancer Res. 2018;37(1):279.","journal-title":"J Exp Clin Cancer Res"},{"issue":"12","key":"1173_CR18","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41419-021-04386-0","volume":"12","author":"K Guo","year":"2021","unstructured":"Guo K, Qian K, Shi Y, Sun T, Wang Z. LncRNA-MIAT promotes thyroid cancer progression and function as ceRNA to target EZH2 by sponging miR-150-5p. Cell Death Dis. 2021;12(12):1097.","journal-title":"Cell Death Dis"},{"key":"1173_CR19","doi-asserted-by":"publisher","first-page":"104527","DOI":"10.1016\/j.yexmp.2020.104527","volume":"117","author":"M Taheri","year":"2020","unstructured":"Taheri M, Eghtedarian R, Dinger ME, Ghafouri-Fard S. Dysregulation of non-coding RNAs in autoimmune thyroid disease. Exp Mol Pathol. 2020;117:104527.","journal-title":"Exp Mol Pathol"},{"key":"1173_CR20","doi-asserted-by":"publisher","first-page":"17702","DOI":"10.1038\/srep17702","volume":"5","author":"H Peng","year":"2015","unstructured":"Peng H, Liu Y, Tian J, Ma J, Tang X, Rui K, Tian X, Mao C, Lu L, Xu H, et al. The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto\u2019s Thyroiditis. Sci Rep. 2015;5:17702.","journal-title":"Sci Rep"},{"issue":"7","key":"1173_CR21","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1002\/bjs.11145","volume":"106","author":"N Chereau","year":"2019","unstructured":"Chereau N, Oyekunle TO, Zambeli-Ljepovic A, Kazaure HS, Roman SA, Menegaux F, Sosa JA. Predicting recurrence of papillary thyroid cancer using the eighth edition of the AJCC\/UICC staging system. Br J Surg. 2019;106(7):889\u201397.","journal-title":"Br J Surg"},{"issue":"7","key":"1173_CR22","doi-asserted-by":"publisher","first-page":"e2118526","DOI":"10.1001\/jamanetworkopen.2021.18526","volume":"4","author":"S Xu","year":"2021","unstructured":"Xu S, Huang H, Qian J, Liu Y, Huang Y, Wang X, Liu S, Xu Z, Liu J. Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes. JAMA Netw Open. 2021;4(7):e2118526.","journal-title":"JAMA Netw Open"},{"issue":"11","key":"1173_CR23","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 2019;28(11):1947\u201351.","journal-title":"Protein Sci"},{"issue":"4","key":"1173_CR24","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s11154-018-9474-z","volume":"19","author":"R Vita","year":"2018","unstructured":"Vita R, Ieni A, Tuccari G, Benvenga S. The increasing prevalence of chronic lymphocytic thyroiditis in papillary microcarcinoma. Rev Endocr Metab Disord. 2018;19(4):301\u20139.","journal-title":"Rev Endocr Metab Disord"},{"key":"1173_CR25","doi-asserted-by":"publisher","first-page":"769294","DOI":"10.1155\/2014\/769294","volume":"2014","author":"X Liu","year":"2014","unstructured":"Liu X, Zhu L, Cui D, Wang Z, Chen H, Duan Y, Shen M, Wu Y, Rong R, Zhang Z, et al. Coexistence of Histologically Confirmed Hashimoto\u2019s Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort. Int J Endocrinol. 2014;2014:769294.","journal-title":"Int J Endocrinol"},{"issue":"4","key":"1173_CR26","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3803\/EnM.2018.33.4.473","volume":"33","author":"S Moon","year":"2018","unstructured":"Moon S, Chung HS, Yu JM, Yoo HJ, Park JH, Kim DS, Park YJ. Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies. Endocrinol Metab (Seoul). 2018;33(4):473\u201384.","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"2","key":"1173_CR27","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3803\/EnM.2020.35.2.443","volume":"35","author":"O Sulaieva","year":"2020","unstructured":"Sulaieva O, Chernenko O, Selesnov O, Nechay O, Maievskyi O, Falalyeyeva T, Kobyliak N, Tsyryuk O, Penchuk Y, Shapochka D. Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment. Endocrinol Metab (Seoul). 2020;35(2):443\u201355.","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"1","key":"1173_CR28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40425-018-0483-y","volume":"7","author":"S Imam","year":"2019","unstructured":"Imam S, Dar P, Paparodis R, Almotah K, Al-Khudhair A, Hasan SA, Salim N, Jaume JC. Nature of coexisting thyroid autoimmune disease determines success or failure of tumor immunity in thyroid cancer. J Immunother Cancer. 2019;7(1):3.","journal-title":"J Immunother Cancer"},{"issue":"9","key":"1173_CR29","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1530\/ERC-17-0085","volume":"24","author":"V Marotta","year":"2017","unstructured":"Marotta V, Sciammarella C, Chiofalo MG, Gambardella C, Bellevicine C, Grasso M, Conzo G, Docimo G, Botti G, Losito S, et al. Hashimoto\u2019s thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer. Endocr Relat Cancer. 2017;24(9):485\u201393.","journal-title":"Endocr Relat Cancer"},{"issue":"10","key":"1173_CR30","doi-asserted-by":"publisher","first-page":"e0223371","DOI":"10.1371\/journal.pone.0223371","volume":"14","author":"C Udagawa","year":"2019","unstructured":"Udagawa C, Horinouchi H, Shiraishi K, Kohno T, Okusaka T, Ueno H, Tamura K, Ohe Y, Zembutsu H. Whole genome sequencing to identify predictive markers for the risk of drug-induced interstitial lung disease. PLoS One. 2019;14(10):e0223371.","journal-title":"PLoS One"},{"issue":"2","key":"1173_CR31","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1183\/09031936.00094910","volume":"38","author":"M Romagnoli","year":"2011","unstructured":"Romagnoli M, Nannini C, Piciucchi S, Girelli F, Gurioli C, Casoni G, Ravaglia C, Tomassetti S, Gurioli C, Gavelli G, et al. Idiopathic nonspecific interstitial pneumonia: an interstitial lung disease associated with autoimmune disorders? Eur Respir J. 2011;38(2):384\u201391.","journal-title":"Eur Respir J"},{"key":"1173_CR32","doi-asserted-by":"publisher","first-page":"813031","DOI":"10.3389\/fimmu.2022.813031","volume":"13","author":"X Wang","year":"2022","unstructured":"Wang X, Lu Y, Liu Z, Zhang Y, He Y, Sun C, Li L, Zhai Q, Meng B, Ren X, et al. A 9-LncRNA Signature for Predicting Prognosis and Immune Response in Diffuse Large B-Cell Lymphoma. Front Immunol. 2022;13:813031.","journal-title":"Front Immunol"},{"issue":"9","key":"1173_CR33","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1101\/gr.9.9.803","volume":"9","author":"E Seroussi","year":"1999","unstructured":"Seroussi E, Kedra D, Pan HQ, Peyrard M, Schwartz C, Scambler P, Donnai D, Roe BA, Dumanski JP. Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts. Genome Res. 1999;9(9):803\u201314.","journal-title":"Genome Res"},{"issue":"1","key":"1173_CR34","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1186\/s12885-022-09673-3","volume":"22","author":"Z Cai","year":"2022","unstructured":"Cai Z, Tang B, Chen L, Lei W. Mast cell marker gene signature in head and neck squamous cell carcinoma. BMC Cancer. 2022;22(1):577.","journal-title":"BMC Cancer"},{"issue":"3","key":"1173_CR35","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1002\/jcp.27180","volume":"234","author":"Q Li","year":"2019","unstructured":"Li Q, Wang B, Mu K, Zhang JA. The pathogenesis of thyroid autoimmune diseases: New T lymphocytes - Cytokines circuits beyond the Th1-Th2 paradigm. J Cell Physiol. 2019;234(3):2204\u201316.","journal-title":"J Cell Physiol"},{"issue":"10","key":"1173_CR36","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1089\/thy.2007.0267","volume":"17","author":"H Kimura","year":"2007","unstructured":"Kimura H, Caturegli P. Chemokine orchestration of autoimmune thyroiditis. Thyroid. 2007;17(10):1005\u201311.","journal-title":"Thyroid"},{"issue":"11","key":"1173_CR37","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1089\/thy.2016.0660","volume":"27","author":"S Yapa","year":"2017","unstructured":"Yapa S, Mulla O, Green V, England J, Greenman J. The Role of Chemokines in Thyroid Carcinoma. Thyroid. 2017;27(11):1347\u201359.","journal-title":"Thyroid"},{"key":"1173_CR38","doi-asserted-by":"publisher","first-page":"766016","DOI":"10.3389\/fonc.2022.766016","volume":"12","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Lu KN, Ding JW, Peng Y, Pan G, Teng LS, Luo DC. Identification of Long Noncoding RNAs Associated With the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated With Hashimoto\u2019s Thyroiditis. Front Oncol. 2022;12:766016.","journal-title":"Front Oncol"},{"issue":"4","key":"1173_CR39","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1111\/ene.14657","volume":"28","author":"S Pfeuffer","year":"2021","unstructured":"Pfeuffer S, Ruck T, Rolfes L, Pawlowski M, Pawlitzki M, Wiendl H, Kovac S, Meuth SG. Patients with a relapsing course of steroid-responsive encephalopathy associated with autoimmune thyroiditis exhibit persistent intrathecal CD4+ T-cell activation. Eur J Neurol. 2021;28(4):1284\u201391.","journal-title":"Eur J Neurol"},{"issue":"29","key":"1173_CR40","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.2174\/138161211798157559","volume":"17","author":"M Rotondi","year":"2011","unstructured":"Rotondi M, Chiovato L. The chemokine system as a therapeutic target in autoimmune thyroid diseases: a focus on the interferon-gamma inducible chemokines and their receptor. Curr Pharm Des. 2011;17(29):3202\u201316.","journal-title":"Curr Pharm Des"},{"issue":"6","key":"1173_CR41","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1586\/17512433.2016.1157468","volume":"9","author":"P Fallahi","year":"2016","unstructured":"Fallahi P, Ferrari SM, Elia G, Nasini F, Colaci M, Giuggioli D, Vita R, Benvenga S, Ferri C, Antonelli A. Novel Therapies for Thyroid Autoimmune Diseases. Expert Rev Clin Pharmacol. 2016;9(6):853\u201361.","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"6","key":"1173_CR42","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3109\/08916934.2011.561818","volume":"44","author":"M Cakir","year":"2011","unstructured":"Cakir M, Levendoglu F, Kiyici A, Coskun Y. Serum CXCL10 levels and neuromuscular manifestations in patients with autoimmune thyroid diseases. Autoimmunity. 2011;44(6):496\u2013503.","journal-title":"Autoimmunity"},{"issue":"1","key":"1173_CR43","first-page":"28","volume":"67","author":"I Pirola","year":"2020","unstructured":"Pirola I, Rotondi M, Cristiano A, Maffezzoni F, Pasquali D, Marini F, Coperchini F, Paganelli M, Apostoli P, Chiovato L, et al. Selenium supplementation in patients with subclinical hypothyroidism affected by autoimmune thyroiditis: Results of the SETI study. Endocrinol Diabetes Nutr (Engl Ed). 2020;67(1):28\u201335.","journal-title":"Endocrinol Diabetes Nutr (Engl Ed)"},{"issue":"4","key":"1173_CR44","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2174\/1871530319666191202115149","volume":"20","author":"B Liu","year":"2020","unstructured":"Liu B, Zheng T, Dong L, Mao C, Xu C, Mou X, Luo X, Lu Q, Dong X, Liu J, et al. Caveolin-1 Regulates CCL5 and PPARgamma Expression in Nthy-ori 3\u20131 Cells: Possible Involvement of Caveolin-1 and CCL5 in the Pathogenesis of Hashimoto\u2019s Thyroiditis. Endocr Metab Immune Disord Drug Targets. 2020;20(4):609\u201318.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"5","key":"1173_CR45","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/MED.0000000000000570","volume":"27","author":"U Feldt-Rasmussen","year":"2020","unstructured":"Feldt-Rasmussen U. Hashimoto\u2019s thyroiditis as a risk factor for thyroid cancer. Curr Opin Endocrinol Diabetes Obes. 2020;27(5):364\u201371.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"10","key":"1173_CR46","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s12149-021-01644-1","volume":"35","author":"D Albano","year":"2021","unstructured":"Albano D, Dondi F, Zilioli V, Panarotto MB, Galani A, Cappelli C, Bertagna F, Giubbini R, Casella C. The role of Hashimoto thyroiditis in predicting radioiodine ablation efficacy and prognosis of low to intermediate risk differentiated thyroid cancer. Ann Nucl Med. 2021;35(10):1089\u201399.","journal-title":"Ann Nucl Med"},{"issue":"6","key":"1173_CR47","doi-asserted-by":"publisher","first-page":"e0269995","DOI":"10.1371\/journal.pone.0269995","volume":"17","author":"Q Tang","year":"2022","unstructured":"Tang Q, Pan W, Peng L. Association between Hashimoto thyroiditis and clinical outcomes of papillary thyroid carcinoma: a meta-analysis. PLoS One. 2022;17(6):e0269995.","journal-title":"PLoS One"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-022-01173-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-022-01173-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-022-01173-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T08:06:15Z","timestamp":1666253175000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-022-01173-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,20]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1173"],"URL":"https:\/\/doi.org\/10.1186\/s12902-022-01173-6","relation":{},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,20]]},"assertion":[{"value":"2 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent regarding study objective, general use of tissue samples and clinical information was obtained from each participant. All methods were carried out in accordance with relevant guidelines and regulations of the Declaration of Helsinki, with Institutional Review Board approval from Zhongnan Hospital of Wuhan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declared no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"252"}}