{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:27:12Z","timestamp":1759177632876},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The study aimed to investigate the attitudes of people with diabetes mellitus (DM) on COVID-19 vaccination and its influence on the glycemic control.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data were collected from a consecutive series of adults (age\u2009&gt;\u200918\u00a0years) with type 2 diabetes under regular follow-ups in the Integrated Care Diabetes Outpatient Clinic of Peking University First Hospital from December 1<jats:sup>st<\/jats:sup> to December 31<jats:sup>st<\/jats:sup> 2021. An online interview questionnaire was conducted, and demographic data including age, sex category, history of drug allergy, history of hypertension, the duration of diabetes, reasons for vaccine hesitancy (VH) and adverse reactions after each injection of vaccines was collected. Glucose levels were collected from medical records.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirty-nine (22.9%) subjects experienced VH and 131 (77.1%) people living with diabetes received inactivated vaccine against COVID-19. Hesitant individuals had a higher proportion of female gender (vaccinated group vs. VH group, 62\/131 vs. 26\/39, <jats:italic>p<\/jats:italic>\u2009=\u20090.044), higher baseline glycosylated hemoglobin A<jats:sub>1c<\/jats:sub> (HbA<jats:sub>1c<\/jats:sub>) (vaccinated group vs. VH group, 6.56\u2009\u00b1\u20090.95% vs. 7.54\u2009\u00b1\u20092.01%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and elevated baseline postprandial blood glucose (PBG) (vaccinated group vs. VH group, 8.32\u2009\u00b1\u20091.97\u00a0mmol\/L vs. 9.44\u2009\u00b1\u20092.94\u00a0mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.015). Subjects of male gender (<jats:italic>p<\/jats:italic>\u2009=\u20090.025) and history of hypertension (<jats:italic>p<\/jats:italic>\u2009=\u20090.021) were likely to get vaccinated, while higher HbA1c was negatively associated with an elevated propensity to receive anti-COVID-19 vaccine (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). Most common reasons for hesitating to receive COVID-19 vaccination were worrying about the possibility of leading to other diseases (30.8%), followed by fearing of glucose variation (17.9%). Systemic adverse reactions were reported in 30.5% individuals after the first injection of inactivated vaccines, and resolved within 3\u00a0days in medium. Fasting blood glucose (FBG) decreased significantly after the third injection compared with FBG after the second dose (second vs. third, 6.78\u2009\u00b1\u20091.24\u00a0mmol\/L vs. 6.41\u2009\u00b1\u20091.30\u00a0mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.027). HbA<jats:sub>1c<\/jats:sub> reduced significantly from 6.56% before vaccination to 6.35% after the second injection (<jats:italic>p<\/jats:italic>\u2009=\u20090.012).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our study demonstrated that vaccine hesitancy was lower among male subjects and people with hypertension, while vaccine confidence was reduced in people with poor glycemic control. HbA<jats:sub>1c<\/jats:sub> level was lower along with vaccination.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-022-01201-5","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:02:47Z","timestamp":1671764567000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The COVID-19 vaccination hesitancy among Chinese individuals with diabetes and the impact on glycemic control of vaccination: a questionnaire study"],"prefix":"10.1186","volume":"22","author":[{"given":"Difei","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"issue":"9","key":"1201_CR1","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/S2213-8587(20)30238-2","volume":"8","author":"M Apicella","year":"2020","unstructured":"Apicella M, Campopiano MC, Mantuano M, et al. 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The study protocol was approved by the Ethical Board of Peking University First Hospital in accordance with Helsinki Declaration.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agreed on the publication of this case report, and written consent to publish was attained from all authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Difei Lu, Xiaojing Qi, Ang Li, Ying Gao and Junqing Zhang declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"329"}}