{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:02:17Z","timestamp":1792551737967,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To evaluate the association of vitamin D and thyroid-stimulating hormone (TSH) with weight loss (WL) percentage (%) in patients with diabetes\/prediabetes and Class II\/III obesity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective cohort study was designed. Data were collected from a database of a referral endocrinology clinic that is prospectively and systematically generated. After exclusion of unavailable cases, the study enrolled 285 patients (51\u2009\u00b1\u200911\u2009years old, female\/male\u2009=\u2009208\/77; diabetes\/prediabetes\u2009=\u2009159\/126; no\/on levothyroxine replacement\u2009=\u2009176\/109; Class II\/III obesity\u2009=\u2009184\/101, respectively) who maintained euthyroidism and were followed up for \u22656\u2009months. The data were analyzed to determine the predictors of WL%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Compared with baseline, in the median 22\u2009months of follow-up, the whole study group lost 5.1% of their baseline body weight. As most obesity management trials define success as \u2018at least 10% of WL compared to baseline\u2019, we stratified the patients based on WL% extents. The distribution was as follow: Group 1 (<jats:italic>n<\/jats:italic>\u2009=\u200961) lost \u226510% body weight, Group 2 (<jats:italic>n<\/jats:italic>\u2009=\u2009162) lost &lt;\u200910% body weight, while Group 3 (<jats:italic>n<\/jats:italic>\u2009=\u200962) gained weight by the final visit. In groups 1 and 2 (weight losers), the serum thyroid stimulatig hormone (TSH) and parathyroid hormone (PTH) levels decreased and the free thyroxine (fT4), calcium, phosphorus, and 25-hydroxyvitamin D (25(OH)D) levels increased. In Group 3 (weight gainers), these changes were not observed (except for an increase in calcium levels). Regression analysis revealed that the final visit TSH (\u03b2\u2009=\u2009\u2212\u20090.14, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), 25(OH) D (\u03b2\u2009=\u20090.15, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and phosphorus (\u03b2\u2009=\u20090.20, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) levels predicted WL%. However, if patients with autoimmune thyroiditis were excluded from the analysis, the decrease in TSH levels was not statistically significant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Serum TSH, phosphorus, and 25(OH) D levels predict WL% in euthyroid patients with diabetes\/prediabetes and morbid obesity. TSH predictivity seems to be a function of thyroid autoimmunity present with increased frequency in this cohort. Greater levels of phosphorus within the reference range and a sufficient vitamin D status are associated with a greater WL%.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-022-01202-4","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T12:03:05Z","timestamp":1668772985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum TSH, 25(OH) D and phosphorus levels predict weight loss in individuals with diabetes\/prediabetes and morbid obesity: a single-center retrospective cohort analysis"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-5491","authenticated-orcid":false,"given":"Kemal","family":"A\u011fbaht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhan Vahit","family":"Pi\u015fkinpa\u015fa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"1202_CR1","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1210\/jc.2004-0535","volume":"89","author":"GA Bray","year":"2004","unstructured":"Bray GA. 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The local authority gave permission for the retrospective analysis (Mustafa Kemal University Faculty of Medicine, ethics committee approval, 07\/01\/2021\u201311\/15).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have nothing to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"282"}}