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Glucose intolerance and insulin resistance are two characteristics that promote the onset and development of type 2 diabetes. The aim of this study was to create a diabetic rat model from obese rat MACAPOS 2.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A group of rats was subjected to a high-fat diet (HFD) compared to a control group (NC) which received a normal diet. After 16\u2009weeks of HFD, Lee index was calculated, obese rats were subjected to an oral glucose tolerance test (OGTT) and insulin tolerance test (ITT). One group of HFD rats (HFDZ) received streptozotocin 22.5\u2009mg\/kg (iv). One week later, weight gain, water and food intakes, urine volume and fasting blood glucose levels were evaluated. Animals were also subjected to glucose tolerance and insulin tolerance tests.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After 16\u2009weeks of HFD, rats became obese, glucose intolerant and resistant to insulin. The body weight of rats was significantly high (+\u200926.23%) compared to normal rats, glycemia remained significantly high (+\u200945.46%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) two hours after administration of glucose in high-fat diet rats, water intake and urine volume were comparable to those of NC. In HFD, the streptozotocin injected after one week (HFDZ), amplified glucose intolerance. During ITT, glycemia remained significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) high from 15\u2009min; and did not vary during the 60\u2009min of ITT. The fasting glycemia one week after streptozotocin injection was significantly high (288\u2009mg\/dL) compared to HFD (114\u2009mg\/dL), associated whit a significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) increase in water intake and 24\u2009h urine volume.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These results showed that MACAPOS 2 associated with a low dose of streptozotocin (22.5\u2009mg\/dL) early leads to the diabetes in obese albinos <jats:italic>Wistar<\/jats:italic> rats and could be a real model to study the type 2 diabetes mellitus.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-022-01252-8","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T02:02:43Z","timestamp":1679277763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early-induced diabetic obese rat MACAPOS 2"],"prefix":"10.1186","volume":"23","author":[{"given":"Joseph","family":"Ngakou Mukam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Mvongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Nkoubat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebtan Olivier","family":"Fankem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adamou","family":"Mfopa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Aim\u00e9","family":"Noubissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Archange","family":"Fokam Tagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Kamgang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Essame Oyono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"issue":"1","key":"1252_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2337\/dc14-S081","volume":"37","author":"American Diabetes Association (ADA)","year":"2014","unstructured":"American Diabetes Association (ADA). 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