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The participants were allocated into two groups (curcumin and placebo) using block randomization method. The treatment group received two 500\u00a0mg edible curcumin tablets together at the same time per day for twelve weeks while the control group received placebo tablets similar to curcumin. Biochemical parameters such as Fasting Blood Insulin (FBI), Fasting Blood Sugar (FBS), triglyceride, total cholesterol, Low Density Lipoprotein- cholesterol (LDL-C), High Density Lipoprotein- cholesterol (HDL-C) were measured before intervention and then 3 months after the intervention. Sex Hormone Binding Globulin (SHBG) and testosterone serum levels were measured 3 months after the intervention. Questionnaires regarding the menstrual cycle characteristics and the Ferriman\u2013Gallwey score were also filled for evaluating hirsutism before the intervention as well as 3 months after the intervention. The independent t-test, Mann-Whitney U test, and ANCOVA were used to analyze the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no statistically significant difference between the two groups in terms of socio-demographic and the baseline levels of measured outcomes. After 12 weeks of intervention, the mean serum FBS levels in the curcumin group were significantly lower than in the placebo group (mean difference: 6.24; 95%confidence interval: -11.73 to -0.76; P\u2009=\u20090.027) but there was no significant difference between the two groups in terms of triglyceride (P\u2009=\u20090.351), cholesterol (P\u2009=\u20090.528), LDL (P\u2009=\u20090.064), HDL (P\u2009=\u20090.306), FBI (p\u2009=\u20090.929), SHBG (p\u2009=\u20090.682), and testosterone (p\u2009=\u20090.133) serum levels. After the intervention, amenorrhea and oligomenorrhea frequency in the curcumin group was significantly lower than in the placebo group (13% vs. 22%, P\u2009=\u20090.038). There was no significant difference in terms of duration of menstruation (P\u2009=\u20090.286) and hirsutism (P\u2009=\u20090.630) between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Curcumin decreased FBS levels and improved menstruation characteristics (amenorrhea, oligomenorrhea, and menstrual irregularities) in women with PCOS but did not affect other metabolic, hormonal, and hirsutism indices. More studies using a larger sample size are required for a definitive conclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Iranian Registry of Clinical Trials (IRCT): IRCT20120718010324N51 Date of registration: 30\/11\/2019. URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/en.irct.ir\/user\/trial\/40597\/view\">https:\/\/en.irct.ir\/user\/trial\/40597\/view<\/jats:ext-link>\n                      ; Date of first registration: 30\/11\/2020.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-023-01295-5","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T07:03:52Z","timestamp":1676963032000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial"],"prefix":"10.1186","volume":"23","author":[{"given":"Niloofar","family":"Ghanbarzadeh-Ghashti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solmaz","family":"Ghanbari-Homaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnaz","family":"Shaseb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamsi","family":"Abbasalizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Mirghafourvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"1295_CR1","doi-asserted-by":"crossref","unstructured":"Reaven GM, Banting. lecture 1988. 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