{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:01:33Z","timestamp":1769274093275,"version":"3.49.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009564","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["20PJ201"],"award-info":[{"award-number":["20PJ201"]}],"id":[{"id":"10.13039\/501100009564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Medical Association","award":["S21039"],"award-info":[{"award-number":["S21039"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Marine Lenhart syndrome is a rare disease and causes refractory hyperthyroidism. So far, little evidence on the combination of both Marine Lenhart syndrome and Hashimoto's thyroiditis is available. We suspect that Marine Lenhart syndrome when combined with Hashimoto's thyroiditis might have its particular features, which are not exactly the same as those of the isolated Marine Lenhart syndrome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 56-year-old middle-aged man presented with recurrent hyperthyroidism, and Graves' disease combined with Hashimoto's thyroiditis was considered. Radionuclide imaging showed a hot nodule, but ultrasonography suggested the possibility of malignancy with a category\u00a0of 4B\u00a0according\u00a0to\u00a0the Chinese-Thyroid Imaging-Reporting and Data System (C-TIRADS) model. Fine needle aspiration cytology (FNAC) revealed eosinophilic follicular lesions with papillary features, and prompted that papillary thyroid carcinoma could not be excluded. Partial thyroidectomy was performed and the nodule was proven to be benign by histopathology. The final diagnosis was atypical Marine Lenhart syndrome with Hashimoto's thyroiditis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Marine Lenhart syndrome combined with Hashimoto's thyroiditis has its particular characteristics, showing some signs mimicking malignancy. Limitations of ultrasonography and FNAC in diagnosis should be noted in these scenarios.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-023-01438-8","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:02:20Z","timestamp":1693195340000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of Marine Lenhart syndrome with Hashimoto\u2019s thyroiditis that mimicked thyroid carcinoma"],"prefix":"10.1186","volume":"23","author":[{"given":"Peng","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3900-6138","authenticated-orcid":false,"given":"Dong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"issue":"12","key":"1438_CR1","first-page":"885","volume":"13","author":"ND Charkes","year":"1972","unstructured":"Charkes ND. Graves\u2019 disease with functioning nodules (Marine-Lenhart syndrome). J Nucl Med. 1972;13(12):885\u201392 (PMID:4678244).","journal-title":"J Nucl Med"},{"issue":"7","key":"1438_CR2","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1089\/thy.1998.8.647","volume":"8","author":"NE Carnell","year":"1998","unstructured":"Carnell NE, Valente WA. Thyroid nodules in Graves\u2019 disease: Classification, characterization, and response to treatment. Thyroid. 1998;8(7):571\u20136. https:\/\/doi.org\/10.1089\/thy.1998.8.647.","journal-title":"Thyroid"},{"issue":"4","key":"1438_CR3","doi-asserted-by":"publisher","first-page":"369","DOI":"10.4103\/wjnm.wjnm_130_20","volume":"20","author":"K Agrawal","year":"2021","unstructured":"Agrawal K, Patro PSS, Meher BR, Gnanasegaran G. Prevalence of Marine-Lenhart syndrome on 99mTc-thyroid scintigraphy and response to radioiodine: A single institutional retrospective study. 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Am J Med. 2021;134(11):e557\u20138. https:\/\/doi.org\/10.1016\/j.amjmed.2021.05.030.","journal-title":"Am J Med"},{"issue":"1","key":"1438_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/jgf2.220","volume":"20","author":"K Oka","year":"2018","unstructured":"Oka K, Yasuda M, Shien T, Otsuka F. A marked goiter involved in Marine-Lenhart syndrome. J Gen Fam Med. 2018;20(1):37\u20138. https:\/\/doi.org\/10.1002\/jgf2.220.","journal-title":"J Gen Fam Med"},{"issue":"12","key":"1438_CR9","doi-asserted-by":"publisher","first-page":"e20558","DOI":"10.7759\/cureus.20558","volume":"13","author":"CA Builes Barrera","year":"2021","unstructured":"Builes Barrera CA, Casta\u00f1o PA, Herrera Revollo P, P\u00e9rez Paternina ME, Rodriguez Arrieta LA. Type 2 Marine-Lenhart syndrome: An uncommon cause of thyrotoxicosis. Cureus. 2021;13(12):e20558. https:\/\/doi.org\/10.7759\/cureus.20558.","journal-title":"Cureus."},{"issue":"6","key":"1438_CR10","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1055\/s-0029-1212022","volume":"106","author":"S Poertl","year":"1998","unstructured":"Poertl S, Kirner J, Saller B, Mann K, Hoermann R. T3-release from autonomously functioning thyroid nodules in vitro. Exp Clin Endocrinol Diabetes. 1998;106(6):489\u201393. https:\/\/doi.org\/10.1055\/s-0029-1212022.","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"5","key":"1438_CR11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/cyt.12575","volume":"29","author":"DC Malheiros","year":"2018","unstructured":"Malheiros DC, Canberk S, Poller DN, Schmitt F. Thyroid FNAC: Causes of false-positive results. 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The institutional review board of the Second People\u2019s Hospital of Chengdu approved this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of the patient\u2019s clinical details and clinical images was obtained from the patient. A copy of the consent form is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"181"}}