{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:10:51Z","timestamp":1792800651600,"version":"4.5.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science","award":["2021-1-I2M-022"],"award-info":[{"award-number":["2021-1-I2M-022"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science","award":["2021-1-I2M-022"],"award-info":[{"award-number":["2021-1-I2M-022"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Familial dysalbuminemic hyperthyroxinemia (FDH) is an autosomal dominant disease characterised by an abnormally increased affinity of albumin for serum thyroxine. Assay interference and differential diagnosis remain challenging for FDH. The condition is more complicated when FDH is combined with primary thyroid diseases. Co-occurrence of FDH and Graves\u2019 disease is rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a 28-year-old woman with complex FDH and coexisting Graves\u2019 disease. Initially, the existence of FDH was not recognised. Graves\u2019 disease was relieved after treatment with antithyroid drugs and two administrations of radioactive iodine therapy. She subsequently developed primary hypothyroidism and was prescribed levothyroxine replacement. However, thyroid function failed to normalise despite frequent levothyroxine dose adjustments. Ultimately, syndromes involving the inappropriate secretion of thyroid-stimulating hormone (IST) were considered, and FDH was successfully differentiated from other causes of IST.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A greater focus on FDH when investigating the causes of IST is critical to correctly evaluate thyroid function status and avoid inappropriate treatment, especially in complicated cases with concurrent FDH and primary thyroid diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-023-01481-5","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T02:02:19Z","timestamp":1697594539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Familial dysalbuminemic hyperthyroxinemia combined with Graves\u2019 disease: a rare case report"],"prefix":"10.1186","volume":"23","author":[{"given":"Yuanmeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naishi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"1481_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3389\/fendo.2017.00297","volume":"8","author":"U Kragh-Hansen","year":"2017","unstructured":"Kragh-Hansen U, Galliano M, Minchiotti L. Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia. Front Endocrinol (Lausanne). 2017;8:297.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1481_CR2","doi-asserted-by":"crossref","unstructured":"Hennemann G, Docter R, Krenning EP, Bos G, Otten M, Visser TJ. Raised total thyroxine and free thyroxine index but normal free thyroxine. A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein. Lancet. 1979;1(8117):639\u201342.","DOI":"10.1016\/S0140-6736(79)91080-8"},{"issue":"2","key":"1481_CR3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1210\/jcem-49-2-292","volume":"49","author":"WN Lee","year":"1979","unstructured":"Lee WN, Golden MP, Van Herle AJ, Lippe BM, Kaplan SA. Inherited abnormal thyroid hormone-binding protein causing selective increase of total serum thyroxine. 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Copyright \u00a9 2000\u20132022, MDText.com, Inc.; 2000."},{"issue":"6","key":"1481_CR6","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1530\/EJE-19-1021","volume":"182","author":"S Khoo","year":"2020","unstructured":"Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, et al. Familial dysalbuminaemic hyperthyroxinaemia interferes with current free thyroid hormone immunoassay methods. Eur J Endocrinol. 2020;182(6):533\u20138.","journal-title":"Eur J Endocrinol"},{"key":"1481_CR7","doi-asserted-by":"crossref","unstructured":"Dieu X, Bouzamondo N, Briet C, Illouz F, Moal V, Boux de Casson F, et al. Familial Dysalbuminemic Hyperthyroxinemia: An Underdiagnosed Entity. J Clin Med. 2020;9(7):2105.","DOI":"10.3390\/jcm9072105"},{"issue":"9","key":"1481_CR8","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1089\/thy.2019.0470","volume":"30","author":"R Han","year":"2020","unstructured":"Han R, Shen L, Zhang J, Xie J, Fang W, Sun Q, et al. 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Am J Med Sci. 2020;360(5):566\u201374.","journal-title":"Am J Med Sci"}],"container-title":["BMC Endocrine Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-023-01481-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12902-023-01481-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12902-023-01481-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T15:14:42Z","timestamp":1700493282000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-023-01481-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1481"],"URL":"https:\/\/doi.org\/10.1186\/s12902-023-01481-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2572923\/v1","asserted-by":"object"}]},"ISSN":["1472-6823"],"issn-type":[{"value":"1472-6823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]},"assertion":[{"value":"10 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Peking Union Medical College Hospital Ethics Committee. Written informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for the publication of their clinical details and\/or clinical images was obtained from the patient. A copy of the consent form is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"226"}}