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All of the patients underwent [<jats:sup>13<\/jats:sup>N]N-NH3 and [<jats:sup>11<\/jats:sup>C]C-MET PET\/CT, after which the pattern of tracer uptake was studied, the tumor position was located, and a clinical decision was made.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In general, [<jats:sup>11<\/jats:sup>C]C-MET had a higher uptake in pituitary adenomas (PAs) than that in pituitary tissues, while [<jats:sup>13<\/jats:sup>N]N-NH3 had a higher uptake in pituitary tissue than in pituitary adenomas. Increased [<jats:sup>11<\/jats:sup>C]C-MET uptake was observed in all nine PAs and three pituitary tissues, while all pituitary tissues and only one pituitary adenoma showed increased [<jats:sup>13<\/jats:sup>N]N-NH3 uptake. Four patients had concordant imaging and surgical findings indicative of biochemical remission without hypopituitarism after treatment. Radiotherapy was adopted in two patients, medication in another two, and follow-up observation in one case.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Combined [<jats:sup>11<\/jats:sup>C]C-MET and [<jats:sup>13<\/jats:sup>N]N-NH3 PET\/CT is effective in the differentiation of PAs from pituitary tissue in recurrent functional PAs with negative MRI or [<jats:sup>18<\/jats:sup>F]F-FDG PET. These results provide a valuable reference for further disease management.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-024-01543-2","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T03:07:12Z","timestamp":1707102432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical application of combination [11C]C-methionine and [13N]N-ammonia PET\/CT in recurrent functional pituitary adenomas with negative MRI or [18F]F-FDG PET\/CT"],"prefix":"10.1186","volume":"24","author":[{"given":"Zongming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zize","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"1543_CR1","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/cncr.20412","volume":"101","author":"S Ezzat","year":"2004","unstructured":"Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML, et al. 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