{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:46:27Z","timestamp":1783359987498,"version":"3.54.6"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetes mellitus (DM) is a worldwide pandemic affecting 500\u00a0million people. It is known to be associated with increased susceptibility to soft tissue infections (STI). Despite being a major public health burden, the literature relating the effects of DM and the presentation, severity and healing of STIs in general surgical patients remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted a retrospective review of all patients admitted with STI in a tertiary teaching hospital over a 12-month period. Patient demographics and surgical outcomes were collected and analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 1059 patients were admitted for STIs (88% required surgery). DM was an independent risk factor for LOS. Diabetic patients presented with higher body-mass index (28 vs. 26), larger abscess size (24 vs. 14 cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and had a longer length of stay (4.4 days vs. 2.9 days). They also underwent a higher proportion of wide debridement and application of negative pressure wound therapy (42% vs. 35%). More diabetic patients underwent subsequent re-operation within the same sitting (8 vs. 4). Diabetic patients were two times more likely to present with carbuncles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of STIs among DM patients represent a significant disease burden, surgeons should consider intensive patient counselling and partnering with primary care providers in order to help reduce the incidence of future STI admissions based upon lifestyle modification and glucose control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-024-01636-y","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T06:04:02Z","timestamp":1720418642000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The interplay between diabetes Mellitus and soft tissue infections in general surgical patients"],"prefix":"10.1186","volume":"24","author":[{"given":"Stephanie","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Rui-Min","family":"Poh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivyan Wei Yen","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piea Peng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"1636_CR1","unstructured":"Federation ID. 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Type 2 DM and its impact on the immune system. Curr DM Reviews. 2020;16(5):442.","journal-title":"Curr DM Reviews"},{"issue":"1","key":"1636_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13098-016-0176-y","volume":"8","author":"GMC de Macedo","year":"2016","unstructured":"de Macedo GMC, Nunes S, Barreto T. Skin disorders in DM mellitus: an epidemiology and physiopathology review. Diabetol Metab Syndr. 2016;8(1):1\u20138.","journal-title":"Diabetol Metab Syndr"},{"key":"1636_CR6","doi-asserted-by":"crossref","unstructured":"Quantifying the risk of infectious diseases for people with DM. B.R, Shah. and J.E. Hux. DM Care, 26 (2003), pp. 510\u2013513.","DOI":"10.2337\/diacare.26.2.510"},{"key":"1636_CR7","doi-asserted-by":"crossref","unstructured":"Sartelli, M., Guirao, X., Hardcastle, T. C., Kluger, Y., Boermeester, M., Ra\u015fa, K.,\u2026 Catena, F. 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Data obtained was retrospective and de-identified and requirement for obtaining individual patient consent was waived by the IRB. The requirement for informed consent was waived by the Ethics Committee of (Institutional review board, Singapore General Hospital) because of the retrospective nature of the study. All methods were carried out in accordance with relevant guidelines and regulations in the declaration of Helsinki","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"106"}}