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Serum\/ovarian adiponectin levels were lowered in LET-treated mice. In mice treated with LET, we also discovered a reduction in cardiac and serum paraoxonase 1 (PON1). Interestingly, DIC restored ovarian andcardio-metabolic abnormalities in LET-induced PCOS mice. DIC prevented the endocrine and cardio-metabolic changes brought on by letrozole-induced PCOS in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ameliorative effects of DIC on letrozole-induced PCOS with concurrent oxidative stress, abdominal fat deposition, cardiac and ovarian substrate mishandling, glucometabolic dysfunction, and adiponectin\/PON1 activation support the idea that DIC perhaps, restore compromised endocrine and cardio-metabolic regulators in PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12902-024-01639-9","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T23:37:19Z","timestamp":1720568239000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diacerein mitigates endocrine and cardio-metabolic disruptions in experimental PCOS mice model by modulating AdipoR1\/ PON 1"],"prefix":"10.1186","volume":"24","author":[{"given":"Mohd Zahoor ul haq","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinoy Kumar","family":"Shrivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Showkeen","family":"Muzamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-9688","authenticated-orcid":false,"given":"Kehinde S.","family":"Olaniyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"issue":"1","key":"1639_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12958-022-00967-6","volume":"20","author":"G Guney","year":"2020","unstructured":"Guney G, Ta\u015fk\u0131n MI, Sener N, Tolu E, Dodurga Y, Elmas L, Cetin O, Sarigul C. 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